Circulating Levels of WISP-1 (Wnt1-Inducible Signaling Pathway Protein 1) and Other Selected Adipokines in Children With Inflammatory Bowel Disease

Karásková, Eva; Kubickova, V; Velganova-Veghova, Maria; Geryk, Miloš; Foltenova, H; Karásek, David

doi:10.33549/physiolres.934854

Cited by 4 publications

(8 citation statements)

References 43 publications

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“…In Hispanic females, there was a lack of the typical postpubertal increase in adiponectin that is observed in non-Hispanic white females [74]. Another recently published study conducted by Karásková et al [75] reported that adiponectin was independently related to BMI in children. The authors also suggested that the adverse production of adipokines can represent the presence of dysfunctional fat tissue in IBD patients.…”

Section: Discussionmentioning

confidence: 99%

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Adiponectin Levels in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Surdea-Blaga¹,

Ismaiel²,

Jaaouani³

et al. 2023

Dig Dis

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Introduction: Adipose tissue plays an important role in the pathogenesis of inflammatory conditions. The role of adipokines in inflammatory bowel disease (IBD) has been evaluated in the current literature with conflicting results. The aim of this study was to evaluate adiponectin levels in IBD patients, including Crohn’s disease (CD) and ulcerative colitis (UC), compared to controls, as well as further subgroup analyses. Hence, assessing the potential role of adiponectin as a surrogate marker. Methods: We performed a systematic electronic search on PubMed, Embase, Scopus, and Cochrane Library, including observational or interventional studies evaluating serum or plasma adiponectin levels in IBD patients in humans. The primary summary outcome was the mean difference (MD) in serum or plasma adiponectin levels between IBD patients versus controls. Subgroup analyses were conducted involving adiponectin levels in CD and UC compared to controls, as well as CD compared to UC. Results: A total of 20 studies were included in our qualitative synthesis and 14 studies in our quantitative synthesis, with a total population sample of 2,085 subjects. No significant MD in serum adiponectin levels was observed between IBD patients versus controls {−1.331 (95% confidence interval [CI]: −3.135–0.472)}, UC patients versus controls (−0.213 [95% CI: −1.898–1.472]), and CD patients versus controls (−0.851 [95% CI: −2.263–0.561]). Nevertheless, a significant MD was found between UC patients versus CD patients (0.859 [95% CI: 0.097–1.622]). Conclusions: Serum adiponectin levels were not able to differentiate between IBD, UC, and CD patients compared to controls. However, significantly higher serum adiponectin levels were observed in UC compared to CD patients.

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Section: Discussionmentioning

confidence: 99%

“…Another recently published study conducted by Karásková et al [75] reported that adiponectin was independently related to BMI in children. The authors also suggested that the adverse production of adipokines can represent the presence of dysfunctional fat tissue in IBD patients.…”

Section: Color Version Available Onlinementioning

confidence: 94%

Adiponectin Levels in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Surdea-Blaga¹,

Ismaiel²,

Jaaouani³

et al. 2023

Dig Dis

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“…Other observations revealed significantly higher concentrations of resistin in pediatric IBD patients compared to the controls. What is more, a positive association between serum resistin and fecal calprotectin together with both CRP and white blood cell count has been noted as well [ 135 , 136 ].…”

Section: Resistin—a Significant Marker Of Systemic Inflammationmentioning

confidence: 99%

Impact of Obesity on the Course of Management of Inflammatory Bowel Disease—A Review

Michalak

Kasztelan-Szczerbińska

Cichoż‐Lach

2022

Nutrients

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It is already well-known that visceral adipose tissue is inseparably related to the pathogenesis, activity, and general outcome of inflammatory bowel disease (IBD). We are getting closer and closer to the molecular background of this loop, finding certain relationships between activated mesenteric tissue and inflammation within the lumen of the gastrointestinal tract. Recently, relatively new data have been uncovered, indicating a direct impact of body fat on the pattern of pharmacological treatment in the course of IBD. On the other hand, ileal and colonic types of Crohn’s disease and ulcerative colitis appear to be more diversified than it was thought in the past. However, the question arises whether at this stage we are able to translate this knowledge into the practical management of IBD patients or we are still exploring the scientific background of this pathology, having no specific tools to be used directly in patients. Our review explores IBD in the context of obesity and associated disorders, focusing on adipokines, creeping fat, and possible relationships between these disorders and the treatment of IBD patients.

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“…Regulatory immune function has been identified in many of them. The role of several adipokines in intestinal inflammation has recently been investigated [ 4 , 15 , 16 ]. The significance of vitamin D deficiency on abnormal production of adipokines in patients with IBD remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease

Geryk,

Kucerova,

Velganova-Veghova

et al. 2024

BMC Pediatr

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Background Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency. Methods The study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants. Results Children with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines. Conclusions Whether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency.

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Circulating Levels of WISP-1 (Wnt1-Inducible Signaling Pathway Protein 1) and Other Selected Adipokines in Children With Inflammatory Bowel Disease

Cited by 4 publications

References 43 publications

Adiponectin Levels in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Adiponectin Levels in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Impact of Obesity on the Course of Management of Inflammatory Bowel Disease—A Review

Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease

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