Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression

Pau, Maria Carmina; Zinellu, Elisabetta; Fois, Sara S.; Piras, Bastiana; Pintus, Gianfranco; Carru, Ciriaco; Mangoni, Arduino A.; Fois, Alessandro Giuseppe; Zinellu, Angelo; Pirina, Pietro

doi:10.3390/antiox10071053

Cited by 15 publications

(12 citation statements)

References 56 publications

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“…The indicators which were examined to represent changes in oxidative stress included MDA, SOD, GSH, GSSG, and the ratio of GSH/GSSG. MDA is a major aldehyde produced by the peroxidation decomposition of unsaturated fatty acids, a studied indicator of the degrees of lipid peroxidation, reflecting the overproduction of ROS and the ability to surpass the endogenous antioxidant defense system ( Liu et al, 2020 ; Pau et al, 2021 ). In addition, the antioxidant enzymes SOD and GSH and GSSG play an important role in regulating the balance of the oxidative stress system.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease

Zou

Cheng

et al. 2022

Front. Pharmacol.

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Alzheimer’s disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive dysfunction in the elderly, with amyloid-beta (Aβ) deposition and hyperphosphorylation of tau protein as the main pathological feature. Nuclear factor 2 (Nrf2) is a transcription factor that primarily exists in the cytosol of hippocampal neurons, and it is considered as an important regulator of autophagy, oxidative stress, and inflammation. Total saikosaponins (TS) is the main bioactive component of Radix bupleuri (Chaihu). In this study, it was found that TS could ameliorate cognitive dysfunction in APP/PS1 transgenic mice and reduce Aβ generation and senile plaque deposition via activating Nrf2 and downregulating the expression of β-secretase 1 (BACE1). In addition, TS can enhance autophagy by promoting the expression of Beclin-1 and LC3-II, increasing the degradation of p62 and NDP52 and the clearance of phosphorylated tau (p-tau), and reducing the expression of p-tau. It can also downregulate the expression of nuclear factor-κB (NF-κB) to inhibit the activation of glial cells and reduce the release of inflammatory factors. In vitro experiments using PC12 cells induced by Aβ, TS could significantly inhibit the aggregation of Aβ and reduce cytotoxicity. It was found that Nrf2 knock-out weakened the inhibitory effect of TS on BACE1 and NF-κB transcription in PC12 cells. Moreover, the inhibitory effect of TS on BACE1 transcription was achieved by promoting the binding of Nrf2 and the promoter of BACE1 ARE1. Results showed that TS downregulated the expression of BACE1 and NF-κB through Nrf2, thereby reducing the generation of Aβ and inhibiting neuroinflammation. Furthermore, TS can ameliorate synaptic loss and alleviate oxidative stress. In gut microbiota analysis, dysbiosis was demonstrated in APP/PS1 transgenic mice, indicating a potential link between gut microbiota and AD. Furthermore, TS treatment reverses the gut microbiota disorder in APP/PS1 mice, suggesting a therapeutic strategy by remodeling the gut microbe. Collectively, these data shows that TS may serve as a potential approach for AD treatment. Further investigation is needed to clarify the detailed mechanisms underlying TS regulating gut microbiota and oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease

Zou

Cheng

et al. 2022

Front. Pharmacol.

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“…Whilst the relationship between oxidative stress and OSA has been extensively explored, controversial results have been reported [ 36 , 37 ]. Several studies investigated the concentrations of oxidant molecules in OSA patients, and their correlation with the severity of the disease [ 38 , 39 ]. A more limited number of studies have sought to elucidate the activity of key antioxidant enzymes, such as SOD and glutathione peroxidase [ 15 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

Pau

Mangoni

Zinellu³

et al. 2021

Antioxidants

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Obstructive Sleep Apnoea (OSA) is characterized by a pro-oxidant state that results from the recurrent hypoxia-reoxygenation cycles. Superoxide dismutase (SOD), a key antioxidant enzyme involved in the detoxification of superoxide radicals, could represent a reliable marker to monitor the antioxidant defences in OSA. In order to capture and critically appraise the available evidence, we performed a systematic review and meta-analysis of studies reporting SOD concentrations in OSA patients and non-OSA controls in the electronic databases Pubmed, Web of Science, Scopus and Google Scholar. In total, 13 studies in 847 OSA patients and 438 non-OSA controls were included in the meta-analysis. Blood SOD concentrations were significantly lower in OSA patients (SMD = 0.87, p < 0.001). By contrast, serum/plasma SOD concentrations were not significantly different between the two groups. Although extreme between-study heterogeneity was observed, the SMD was not substantially modified when individual studies were sequentially removed. In conclusion, we observed that whole blood, but not serum/plasma, SOD concentrations were significantly lower in OSA patients compared with controls. Our meta-analysis suggests an impaired antioxidant defence in OSA that is more robustly assessed in the corpuscular biological matrix and provides useful background information for further studies investigating the association between SOD changes and clinical status in OSA.

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“…Similar results were reported with the protein disulfide reductase thioredoxin [ 112 , 113 ]. In addition, Malondialdehyde, a common biomarker of lipid peroxidation, has also been associated with OSA, correlating with the duration of nocturnal oxygen desaturation below 85% [ 114 , 115 , 116 ].…”

Section: Osa and Cardiovascular Diseasementioning

confidence: 99%

Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases

Alterki

Abu‐Farha

Alshawaf

et al. 2023

IJMS

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Obstructive sleep apnoea (OSA) is a prevalent underdiagnosed disorder whose incidence increases with age and weight. Uniquely characterised by frequent breathing interruptions during sleep—known as intermittent hypoxia (IH)—OSA disrupts the circadian rhythm. Patients with OSA have repeated episodes of hypoxia and reoxygenation, leading to systemic consequences. OSA consequences range from apparent symptoms like excessive daytime sleepiness, neurocognitive deterioration and decreased quality of life to pathological complications characterised by elevated biomarkers linked to endocrine-metabolic and cardiovascular changes. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases. Furthermore, OSA is linked to other conditions that worsen cardiovascular outcomes, such as obesity. The relationship between OSA and obesity is complex and reciprocal, involving interaction between biological and lifestyle factors. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation and metabolic dysregulation. The current medical practice uses continuous positive airway pressure (CPAP) as the gold standard tool to manage OSA. It has been shown to improve symptoms and cardiac function, reduce cardiovascular risk and normalise biomarkers. Nonetheless, a full understanding of the factors involved in the deleterious effects of OSA and the best methods to eliminate their occurrence are still poorly understood. In this review, we present the factors and evidence linking OSA to increased risk of cardiovascular conditions.

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Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression

Cited by 15 publications

References 56 publications

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease

Circulating Superoxide Dismutase Concentrations in Obstructive Sleep Apnoea (OSA): A Systematic Review and Meta-Analysis

Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases

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