2015
DOI: 10.1016/j.thromres.2015.05.029
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Circulating microparticles in umbilical cord blood in normal pregnancy and pregnancy with preeclampsia

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Cited by 34 publications
(23 citation statements)
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“… 9 , 21 Microparticle profiles have been shown to be altered in other proinflammatory states accompanied by platelet activation, including inflammatory types of arthritis, 22 systemic lupus erythematosus, 23 and pre-eclampsia. 24 Consequently, we next aimed to determine the potential contribution of phospholipid components of endogenous MPs to thrombin generation by initiating thrombin generation with TF alone. Under these conditions, lag time to initiation of thrombin generation was significantly reduced in RRMS patients, 7.14 minutes (IQR 5.41–8.34 minutes), compared to HCs, 7.67 minutes (IQR 7.08–12.09 minutes), but not compared to PPMS, 8.33 minutes (IQR 6.75–9.07 minutes) ( Figure 1(c) ).…”
Section: Resultsmentioning
confidence: 99%
“… 9 , 21 Microparticle profiles have been shown to be altered in other proinflammatory states accompanied by platelet activation, including inflammatory types of arthritis, 22 systemic lupus erythematosus, 23 and pre-eclampsia. 24 Consequently, we next aimed to determine the potential contribution of phospholipid components of endogenous MPs to thrombin generation by initiating thrombin generation with TF alone. Under these conditions, lag time to initiation of thrombin generation was significantly reduced in RRMS patients, 7.14 minutes (IQR 5.41–8.34 minutes), compared to HCs, 7.67 minutes (IQR 7.08–12.09 minutes), but not compared to PPMS, 8.33 minutes (IQR 6.75–9.07 minutes) ( Figure 1(c) ).…”
Section: Resultsmentioning
confidence: 99%
“…129,130 MPs are very likely involved in the hypercoagulable and proinflammatory intravascular reactions during PE. 131 Mice injected with phosphatidylserine/ phosphatidylcholine microvesicles showed a significant elevation in systolic blood pressure, a significant increase in TAT level, a significant decrease in platelet count, a decrease in AT, an increase in proteinuria, and a significant reduction in fetal weigh and placental weight, compared with controls. 132 PElike symptoms were significantly alleviated after the phosphatidylserine/phosphatidylcholine microvesicles-injected mice were treated with annexin V, hirudin, or heparin.…”
Section: Assays Of Hemostasis During Normal Pregnancymentioning
confidence: 93%
“…Furthermore, pMVs seem to be involved in the development of disseminated intravascular coagulopathy in critically ill patients but are not related to hospital mortality, while pMV/platelet ratio is independently associated to hospital mortality (Ohuchi et al, 2015). Finally, total pMVs were lower while activated platelet-derived MVs (P-Sel + ) were higher in preeclampsia than in healthy women, being involved in the hypercoagulable intravascular reaction during pregnancies complicated by preeclampsia (Campello et al, 2015). Therefore, pMV may reflect the severity of the endothelial injury and platelet activation during thrombotic events (Tan et al, 2005; Jung et al, 2012).…”
Section: Platelet-derived Microvesicles and Cardiovascular Diseasementioning
confidence: 99%