Circulating microRNA-126 &amp;122 in patients with coronary artery disease: Correlation with small dense LDL

Mishra, Sridhar; Rizvi, Aliya; Pradhan, Akshyaya; Perrone, Marco Alfonso; Ali, Wahid

doi:10.1016/j.prostaglandins.2021.106536

Cited by 19 publications

(14 citation statements)

References 23 publications

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“…Collectively, these studies support that miR-122 correlates positively with atherosclerosis and its severity and suggest that miR-122 is a good biomarker for predicting the development of atherosclerosis. However, there is one exception, where circulating miR-122 levels were significantly downregulated in coronary artery disease patients, according to a recent study by Mishra et al [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes

Luo

Gan

Yuguo

et al. 2022

CIMB

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Atherosclerosis is a major risk factor for type 2 diabetes (T2D) mortality. We aim to investigate the changes in miR-21, miR-122, miR-33a and miR-3064-5p in circulation and the liver of ApoE-/- mice with streptozocin (STZ)-induced T2D. Twenty 5-week-old male ApoE-/- mice were randomly assigned to the control (n = 10) and T2D group (n = 10) and intraperitoneally injected with a citrate buffer and streptozotocin (STZ) (40 mg/kg BW) once a day for three consecutive days. The successfully STZ-induced T2D mice (n = 5) and control mice (n = 5) were then fed with a high-fat diet (HFD) for 34 weeks. Compared to the control mice, ApoE-/- mice with STZ-induced T2D had slower (p < 0.05) growth, increased (p < 0.05) total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), decreased (p < 0.05) high-density lipoprotein cholesterol (HDL-C) in serum, reduced (p < 0.05) TC and sterol regulatory element-binding protein-2 (Srebp-2), elevated (p < 0.05) ATP-binding-cassette-transporter-A1 (Abca1) in the liver, aggravated (p < 0.05) atherosclerotic lesions in the aorta, downregulated (p < 0.05) miR-21 and miR-33a, and upregulated (p < 0.05) miR-122 and miR-3064-5p in serum and the liver. In addition, the aortic lesions showed a positive correlation with miR-122 (r = 1.000, p = 0.001) and a negative correlation with miR-21 (r = −1.000, p = 0.001) in ApoE-/- mice with T2D. In conclusion, T2D-accelerated atherosclerosis correlates with a reduction in miR-21 and miR-33a and an elevation in miR-122 and miR-3064-5p in circulation and the liver of ApoE-/- mice.

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Section: Discussionmentioning

confidence: 99%

The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes

Luo

Gan

Yuguo

et al. 2022

CIMB

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“…The miR-126 level did not change so no significant correlation was found between control and patient groups (p = 0.274). This might be brought on by the study participants' regular use of aspirin and -blockers, which could have an impact on the miR-126 level [36]. These results suggest that miRNA levels were unaffected by anti-platelet treatments [37,38] that was agreed with Fiedler J (2011) [39] and disagreed with Mishra S [35].…”

Section: Roc Curve and Cute-off Analysismentioning

confidence: 75%

Untitled

2023

J. Med. Chem. Sci.

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The current study aimed to evaluate the role and gene target of miR-126 in Iraqi patients with Coronary Artery Disease (CAD) and atherosclerosis (AS). By coverage average age (35 to 65) years old of both genders, a total of 40 patients with CAD and 40 healthy people as a control group were enrolled in this clinical study. The blood samples of patients were taken from Ibn Al-Bitar Diagnostic Center for Heart Surgery in Baghdad/Iraq in December 2020 to April 2021. Overall, the CAD patients had significantly higher (except HDL) total lipid profile (total chol., total Trig., LDL, and VLDL, age, and IL6 levels). Statistically no significant correlation was found between miRNA-126 and lipid parameters in all studied subject. The correlation was found between Triglycerides and his-Troponin (r=-0.521, pv=0.032). The ROC analysis of mRNA126 at UAC 0.976 had sensitivity of (0.80) and 1-specificity of (0.60) were total area under the curve = 759, pv=0.005; that means miRN-126 can be used as a screening test for CAD. Thus, miR126 can be considered as a biomarker on CAD in patient.

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“…There, it was suggested that miR-126 may play a role in the cholesterol metabolism of sdLDL-C. However, the mechanism by which the decrease in circulating miR-126 levels in patients with CAD is proportional to the increase in sdLDL-C is not fully understood ( 42 ). In 2012, miRNAs were reported to be important regulators of HDL metabolism and reverse cholesterol transport, including direct targeting of cellular cholesterol efflux, HDL biogenesis, liver high-density lipoprotein uptake, and the synthesis of bile acid and secretion-related genes ( 43 ).…”

Section: Mechanism Of As Induced By Sdldl-cmentioning

confidence: 99%

“…It has also been reported that miR-126 attenuates oxidized LDL (ox-LDL)-induced endothelial cell injury by inhibiting signal transduction to delay AS ( 44 , 45 ). Therefore, a larger sample cohort is needed to further explain the role of miR-126 in sdLDL-C cholesterol metabolism and to understand the development of the disease ( 42 ) ( Figure 2 ).…”

Section: Mechanism Of As Induced By Sdldl-cmentioning

confidence: 99%

Small, Dense Low-Density Lipoprotein-Cholesterol and Atherosclerosis: Relationship and Therapeutic Strategies

Jin

Yang

et al. 2022

Front. Cardiovasc. Med.

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Low-density lipoprotein cholesterol (LDL-C) plays an important role in the formation, incidence, and development of atherosclerosis (AS). Low-density lipoproteins can be divided into two categories: large and light LDL-C and small, dense low-density lipoprotein cholesterol (sdLDL-C). In recent years, an increasing number of studies have shown that sdLDL-C has a strong ability to cause AS because of its unique characteristics, such as having small-sized particles and low density. Therefore, this has become the focus of further research. However, the specific mechanisms regarding the involvement of sdLDL-C in AS have not been fully explained. This paper reviews the possible mechanisms of sdLDL-C in AS by reviewing relevant literature in recent years. It was found that sdLDL-C can increase the atherogenic effect by regulating the activity of gene networks, monocytes, and enzymes. This article also reviews the research progress on the effects of sdLDL-C on endothelial function, lipid metabolism, and inflammation; it also discusses its intervention effect. Diet, exercise, and other non-drug interventions can improve sdLDL-C levels. Further, drug interventions such as statins, fibrates, ezetimibe, and niacin have also been found to improve sdLDL-C levels.

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Circulating microRNA-126 &122 in patients with coronary artery disease: Correlation with small dense LDL

Cited by 19 publications

References 23 publications

The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes

The Accelerated Progression of Atherosclerosis Correlates with Decreased miR-33a and miR-21 and Increased miR-122 and miR-3064-5p in Circulation and the Liver of ApoE-/- Mice with Streptozocin (STZ)-Induced Type 2 Diabetes

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Small, Dense Low-Density Lipoprotein-Cholesterol and Atherosclerosis: Relationship and Therapeutic Strategies

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