Circulating microRNA-144-5p is associated with depressive disorders

Abstract

Background: Depressive/anxiety disorders are the most common types of mental illnesses in the world. The present study was the first to explore the association between plasma microRNAs (miRNAs) and depression/anxiety in primary care patients.

Assessment of microRNA‐144‐5p and its putative targets in inflamed gingiva from chronic periodontitis patients

“…miR‐144‐5p, first discovered to be a potential biomarker of follicular thyroid cancer, may also be a regulatory factor in various disease, including metabolic disease (metabolic syndrome and diabetes), malignant tumour (non‐small‐cell lung cancer, breast cancer, bladder cancer, oesophageal carcinoma and gastric cancer), inflammatory diseases (tuberculosis, obesity and amyotrophic lateral sclerosis), Alzheimer's disease, depressive disorders and coronary syndrome . miR‐144‐5p inhibited antibacterial autophagy and the immune response to Mycobacterium tuberculosis via repressing DNA damage‐regulated autophagy modulator 2, which is a coordinator of antimicrobial autophagy …”

Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome

“…Sharma et al found that the downregulation of miR-142, a hematopoietic-specific miRNA [34], is a critical element of cardiac adaptive hypertrophy in response to hemodynamic stress [35]. Wang et al studied miR-144, found in blood and a broad range of tissues [36,37], and found that loss of the miR-144/451 cluster limits ischemic preconditioning-mediated cardioprotection [38]. These studies support our finding that the downregulation of miR-126-5p, 142-5p, and 144-5p may be associated with chronic HF.…”

Effect of miR‑144‑5p on the proliferation, migration, invasion and apoptosis of human umbilical vein endothelial cells by targeting RICTOR and its related mechanisms

“…miR-144-5p has been studied in various cancers such as renal cell carcinoma (34) and miR-144-5p has also been studied in chronic periodontitis (35). A previous study demonstrated that circulating miR-144-5p was associated with depressive disorders (36). However, the role and mechanism of miR-144-5p in atherosclerosis remains unclear.…”