2019
DOI: 10.1016/j.ajg.2019.01.011
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Circulating microRNA-155 is associated with insulin resistance in chronic hepatitis C patients

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Cited by 10 publications
(7 citation statements)
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“…Our results regarding the expression of miR-155 are in accordance with those reported in populations from Mexico (31), Egypt (32), Iran (33), Germany (34) and China (13), in which the circulating levels of miR-155 were downregulated in subjects with T2DM in comparison to healthy controls. In a streptozotocin (STZ)-nicotinamide-induced rat model of T2DM, the miR-155 expression was lower in PBMC, kidney, heart, aorta and sciatic nerve obtained from diabetic rats than in their non-diabetic counterparts (35).…”
Section: Discussionsupporting
confidence: 91%
“…Our results regarding the expression of miR-155 are in accordance with those reported in populations from Mexico (31), Egypt (32), Iran (33), Germany (34) and China (13), in which the circulating levels of miR-155 were downregulated in subjects with T2DM in comparison to healthy controls. In a streptozotocin (STZ)-nicotinamide-induced rat model of T2DM, the miR-155 expression was lower in PBMC, kidney, heart, aorta and sciatic nerve obtained from diabetic rats than in their non-diabetic counterparts (35).…”
Section: Discussionsupporting
confidence: 91%
“…The main clinical studies investigating miR-155 and DM are reported in Table 1 . A significant decrease in serum levels of miR-155 in T2D patients has been shown in Italian, Chinese, Egyptian, Brazilian, and Iranian cohorts, exposing a striking consistence among the different ethnic backgrounds [ 39 , 40 , 41 , 42 , 43 ].…”
Section: Dysregulation Of Mir-155 In Dm: Findings From Clinical Studiesmentioning
confidence: 99%
“…Low plasma levels of miR-155 were also found in gestational DM [ 54 ]. Interestingly, patients with hepatitis C and insulin resistance also displayed lower serum levels of miR-155 compared to those with hepatitis C without insulin resistance, although hepatitis C infection was associated with manifold upregulation of this miRNA [ 41 ]. Plasma levels of miR-155-5p were shown to correlate with diabetic neuropathy: patients with diabetic distal symmetric sensorimotor polyneuropathy and diabetic cardiovascular autonomic neuropathy had lower plasma levels of miR-155 compared to DM patients without neurological symptoms [ 39 ].…”
Section: Dysregulation Of Mir-155 In Dm: Findings From Clinical Studiesmentioning
confidence: 99%
“…Previous studies indicated that the levels of miR-155 were upregulated in T1DM and downregulated in T2DM patients ( 19 , 29 31 ). However, whether miR-155 levels are altered in DLI remains to be determined.…”
Section: Resultsmentioning
confidence: 95%