Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer

Tsai, Ming-Ming; Wang, Chia‐Siu; Tsai, Chung‐Ying; Huang, Chung‐Guei; Lee, Kam-Fai; Huang, Hsiang-Wei; Lin, Yang-Hsiang; Chi, Hsiang-Cheng; Kuo, Liang-Mou; Lu, Pei-Hsuan; Lin, Kwang‐Huei

doi:10.1016/j.ejca.2016.05.007

Cited by 64 publications

(39 citation statements)

References 42 publications

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“…Moreover, miR-196a is highly involved in cancer development, although both positive and negative effects have been shown for cancer progression 26-28. These findings suggest that miR-196a plays an important role during the development and progression of various diseases.…”

Section: Discussionmentioning

confidence: 99%

miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease

Her¹,

Mao²,

Chang³

et al. 2017

Theranostics

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MicroRNAs (miRNAs) play important roles in several neurobiological processes, including the development and progression of diseases. Previously, we identified that one specific miRNA, miR-196a, provides neuroprotective effects on Huntington's disease (HD), although the detailed mechanism is still unclear. Based on our bioinformatic analyses, we hypothesize miR-196a might offer neuroprotective functions through improving cytoskeletons of brain cells. Here, we show that miR-196a could enhance neuronal morphology, further ameliorating intracellular transport, synaptic plasticity, neuronal activity, and learning and memory abilities. Additionally, we found that miR-196a could suppress the expression of RAN binding protein 10 (RANBP10) through binding to its 3' untranslated region, and higher expression of RANBP10 exacerbates neuronal morphology and intracellular transport. Furthermore, miR-196a enhances neuronal morphology through suppressing RANBP10 and increasing the ability of β-tubulin polymerization. Most importantly, we observed higher expression of RANBP10 in the brains of HD transgenic mice, and higher expression of RANBP10 might exacerbate the pathological aggregates in HD. Taken together, we provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a. Since miR-196a has also been reported in other neuronal diseases, this study might offer insights with regard to the therapeutic use of miR-196a in other neuronal diseases.

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Section: Discussionmentioning

confidence: 99%

miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease

Her¹,

Mao²,

Chang³

et al. 2017

Theranostics

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show abstract

“…The overexpression of miR-196a has also been shown to play important role in other cancer types. For instance, circulating miR-196a/b has been reported as the novel biomarkers associated with metastatic gastric cancer [14]. High miR-196a has been shown to to be associated with poor prognosis of high-grade glioma [15].…”

Section: Discussionmentioning

confidence: 99%

Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer

Chen

She

et al. 2016

Oncotarget

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Colorectal cancer (CRC) is one of the most common malignant tumour and the leading cause of cancer-related mortality worldwide. Clarification of the mechanism that underlies CRC tumorigenesis and progression therefore is urgently needed ffor developing novel therapies. Through analysis of The Cancer Genome Atlas (TCGA) dataset, we identified an interesting gene, ZG16, which is significantly decreased in CRC samples compared to adjacent non-tumor tissues and associated with prognosis of patients. We found that the expression of ZG16 correlated with CRC related genes which were regulated by APC/CTNNB1 pathway. Interestingly, the expression of ZG16 was negatively correlated with CRC stem cell marker, LGR5. Overexpression of ZG16 significantly inhibits growth and sphere formation of stem-like CRC cells. Moreover, we also identified an upstream regulator of ZG16, miR-196a, which was significantly overexpressed in CRC and promotes cell growth and stemness. In conclusion, this study demonstrated that loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of CRC, which may provide a promising therapeutic strategy for advanced CRCs.

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“…The miR-196 family consists of miR-196a and miR-196b with shared regulatory capacity (3). Studies have shown that miR-196a and miR-196b exert various functions in cancer carcinogenesis and development (4)(5)(6)(7). miR-196a-2 polymorphism is associated with susceptibility to HCC and recurrence after liver transplantation (4,8).…”

Section: Introductionmentioning

confidence: 99%

microRNA‑196b promotes cell migration and invasion by targeting FOXP2 in hepatocellular carcinoma

Lin

Tian

et al. 2017

Oncol Rep

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Accumulating evidence indicates that microRNAs (miRNAs) play important roles in tumorigenesis and metastasis. Recent research has shown that miR‑196b is implicated in metastasis by regulating the migration and invasion of cancer cells. However, the clinical significance of miR‑196b and its role as well as the underlying mechanisms in hepatocellular carcinoma (HCC) remain largely unknown. Here, we detected miR‑196b expression in HCC and matched non-tumor tissues with qRT‑PCR. We found that miR‑196b displayed higher expression in HCC patient tissues and cells. Clinical analysis revealed that high miR‑196 expression was correlated with venous infiltration, advanced TNM stage and poor prognosis. Functionally, we demonstrated that miR‑196b promoted the migration and invasion of HCC cells in vitro. Moreover, miR‑196b knockdown restrained pulmonary metastasis in vivo. Mechanistically, we confirmed that miR‑196b could directly bind to 3'UTR of forkhead box P2 (FOXP2) mRNA and repress its expression. miR‑196b and FOXP2 showed a negative correlation in HCC tissues. More importantly, upregulation of FOXP2 antagonized miR‑196b‑mediated migration and invasion in Hep3B cells. Furthermore, FOXP2 knockdown partially reversed the anti‑metastatic function of the miR‑196b inhibitor on HCCLM3 cells. Taken together, we demonstrated that miR‑196b may function as a prognostic biomarker and suppressed FOXP2 expression, subsequently leading to the metastasis of HCC. Our findings highlight a novel mechanism of miR‑196b in the progression of HCC and identify miR‑196b/FOXP2 axis as a promising target for HCC.

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Circulating microRNA-196a/b are novel biomarkers associated with metastatic gastric cancer

Cited by 64 publications

References 42 publications

miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease

miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease

Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer

microRNA‑196b promotes cell migration and invasion by targeting FOXP2 in hepatocellular carcinoma

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