2021
DOI: 10.1038/s41598-021-03189-9
|View full text |Cite
|
Sign up to set email alerts
|

Circulating microRNA-197-3p as a potential biomarker for asbestos exposure

Abstract: Asbestos is considered the main cause of diseases in workers exposed to this mineral in the workplace as well as an environmental pollutant. The association between asbestos and the onset of different diseases has been reported, but asbestos exposure specific biomarkers are not known. MicroRNAs (miRNAs) are small, single-strand, non-coding RNAs, with potential value as diagnostic, prognostic, and predictive markers in liquid biopsies. Sera collected from workers ex-exposed to asbestos (WEA) fibers were compare… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
10
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
6

Relationship

2
4

Authors

Journals

citations
Cited by 7 publications
(10 citation statements)
references
References 47 publications
0
10
0
Order By: Relevance
“…In a previous study, we reported that the expression of circulating miR-197-3p was significantly downregulated in sera from workers who had previously been exposed to asbestos (WEA) compared to HS 33 and its expression level was inversely correlated with cumulative exposure to asbestos, indicating that miR-197-3p can be considered a new biomarker for exposure to this tumorigenic mineral. Interestingly, comparing the data obtained from MPM reported in this study with those from WEA described in the aforementioned work, the expression of circulating miR-197-3p was higher in the MPM than in the WEA cohort, analyzed by both ddPCR and RT-qPCR, with statistical significance in ddPCR (Tukey's test, P = 0.0036**).…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…In a previous study, we reported that the expression of circulating miR-197-3p was significantly downregulated in sera from workers who had previously been exposed to asbestos (WEA) compared to HS 33 and its expression level was inversely correlated with cumulative exposure to asbestos, indicating that miR-197-3p can be considered a new biomarker for exposure to this tumorigenic mineral. Interestingly, comparing the data obtained from MPM reported in this study with those from WEA described in the aforementioned work, the expression of circulating miR-197-3p was higher in the MPM than in the WEA cohort, analyzed by both ddPCR and RT-qPCR, with statistical significance in ddPCR (Tukey's test, P = 0.0036**).…”
Section: Discussionmentioning
confidence: 99%
“…Serum samples (N = 225) were from malignant pleural mesothelioma affected patients (MPM, n = 75), workers ex-exposed to asbestos (WEA, n = 75) and healthy subjects (HS, N = 75). MPM sera were obtained from the Mesothelioma BioBank, Pathology Unit, City Hospital of Alessandria, Italy, whereas sera from WEA were supplied by the Occupational Medicine Unit, University of Ferrara, Ferrara, Italy, as previously described 33 . HS sera were collected at the Clinical Laboratory Analysis of the University Hospital of Ferrara, Italy.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…Specific miRNAs such as miR-197-3p were found to be significantly downregulated in individuals who were exposed to work-related asbestos than controls. The authors suggested the use of miR-197-3p as a potential biomarker of asbestos exposure [ 57 ]. Earlier Tomassetti et al noted the importance of early detection in the possible reduction of cancer burden and how this could assist in treatment efficacy.…”
Section: Epigenetic Mirna In Other Asbestos-related Diseases Possible...mentioning
confidence: 99%