Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity

Boen, Hanne M.; Cherubin, Martina; Franssen, Constantijn; Gevaert, Andreas B.; Witvrouwen, Isabel; Bosman, Matthias; Guns, Pieter-Jan; Heidbuchel, Hein; Loeys, Bart; Alaerts, Maaike; Van Craenenbroeck, Emeline M.

doi:10.1016/j.jaccao.2023.12.009

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2024

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Cited by 5 publications

References 143 publications

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Atrioventricular Nodal Ablation and Pacing in Refractory Atrial Fibrillation and Heart Failure

Bai,

Shen,

Tung

2024

Cardiac Electrophysiology Clinics

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Atrioventricular Nodal Ablation and Pacing in Refractory Atrial Fibrillation and Heart Failure

Bai,

Shen,

Tung

2024

Cardiac Electrophysiology Clinics

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Anthracycline Cardiotoxicity in Adult Cancer Patients

Camilli,

Cipolla,

Dent

et al. 2024

JACC: CardioOncology

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Regulatory Pathways of Long Non-coding RNAs and MicroRNAs in Sepsis-Induced Cardiomyopathy: Prognostic Biomarkers and Therapeutic Targets

Eini,

amini,

Farzan

et al. 2024

Preprint

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Sepsis-induced cardiomyopathy (SCM) is a life-threatening complication of sepsis, marked by temporary myocardial dysfunction. Emerging evidence highlights the critical roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in regulating the molecular pathways involved in SCM, including inflammation, oxidative stress, and apoptosis. These non-coding RNAs (ncRNAs) are increasingly recognized as valuable diagnostic and prognostic biomarkers, as well as promising therapeutic targets. This review explores the potential of lncRNAs and miRNAs in SCM, focusing on their regulatory functions and therapeutic applications. Key miRNAs, such as miR-495 and miR-21-3p, are highlighted as early diagnostic indicators and modulators of disease progression. Similarly, lncRNAs like MALAT1 and HOTAIR play crucial roles in controlling fibrosis and inflammation within the myocardium. Therapeutic strategies include the use of miRNA mimics to restore miRNA function, antagomiRs to inhibit overexpressed miRNAs, and the modulation of lncRNA expression to mitigate SCM progression. Advanced delivery methods, including CRISPR/Cas9 gene-editing technology, are discussed as innovative approaches to enhance the specificity and efficacy of ncRNA-based therapies. In conclusion, ncRNAs offer significant potential as biomarkers and therapeutic agents in SCM, presenting new avenues for targeted treatment. However, further research is required to address challenges related to delivery, specificity, and long-term safety in clinical applications.

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Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity

Cited by 5 publications

References 143 publications

Atrioventricular Nodal Ablation and Pacing in Refractory Atrial Fibrillation and Heart Failure

Atrioventricular Nodal Ablation and Pacing in Refractory Atrial Fibrillation and Heart Failure

Anthracycline Cardiotoxicity in Adult Cancer Patients

Regulatory Pathways of Long Non-coding RNAs and MicroRNAs in Sepsis-Induced Cardiomyopathy: Prognostic Biomarkers and Therapeutic Targets

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