Circulating MicroRNA in inflammatory bowel disease

Archanioti, Paraskevi; Theodoropoulos, George; Papaconstantinou, Ioannis; Mantzaris, Gerassimos J.; Nikiteas, Nikolaos; Gazouli, Maria

doi:10.1016/j.crohns.2012.02.006

Cited by 222 publications

(180 citation statements)

References 24 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…miR-200b is expressed in a variety of cells and modulates key cellular functions, such as cell proliferation, motility, apoptosis, and stem cell properties, and it controls signals in angiogenesis and epithelial-mesenchymal transition, a process in which epithelial cells acquire mesenchymal characteristics (Brabletz and Brabletz 2010). Regulation of miR-200b/c modifies TLR4 signaling in macrophages, with effects on host innate defenses against periodontal pathogens (Wendlandt et al 2012), while miR-200c-5p was found to be increased in inflammatory bowel disease patients (Paraskevi et al 2012). There have been no studies reporting miR-200b expression in gingival tissue in obesity.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

et al. 2015

View full text Add to dashboard Cite

“…Preliminary studies in IBD, however, have been conflicting, as initial studies found dissimilar miRNA expression profiles compared with tissues, leading to the suggestion that peripheral blood miRNAs may reflect circulating leukocytes rather than expression in remote tissues. However, more recent investigations have been able to demonstrate several previously reported dysregulated tissue miRNAs with increased expression in peripheral blood [Paraskevi et al 2012;Yang et al 2013].…”

Section: Mirna General Overviewmentioning

confidence: 99%

The emerging role of miRNAs in inflammatory bowel disease: a review

Chapman

Pekow

2014

Therap Adv Gastroenterol

140

106

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is believed to develop as a result of a deregulated inflammatory response to environmental factors in genetically susceptible individuals. Despite advances in understanding the genetic risks of IBD, associated single nucleotide polymorphisms have low penetrance, monozygotic twin studies suggest a low concordance rate, and increasing worldwide IBD incidence leave gaps in our understanding of IBD heritability and highlight the importance of environmental influences. Operating at the interface between environment and heritable molecular and cellular phenotypes, microRNAs (miRNAs) are a class of endogenous, small noncoding RNAs that regulate gene expression. Studies to date have identified unique miRNA expression profile signatures in IBD and preliminary functional analyses associate these deregulated miRNAs to canonical pathways associated with IBD pathogenesis. In this review, we summarize and discuss the miRNA expression signatures associated with IBD in tissue and peripheral blood, highlight miRNAs with potential future clinical applications as diagnostic and therapeutic targets, and provide an outlook on how to develop miRNA based therapies.

show abstract

“…Reduced levels of miR124 in colon tissues appear to increase the expression and activity of signal transducer and activator of transcription3, and this mediates the pathogenesis of UC in children [124] . miRNAs in peripheral blood: Paraskevi and colleagues [125] found that six miRNAs (miR16, miR21, miR285p, miR1515p, miR155, and miR199a 5p) were remarkably upregulated in blood from UC patients compared with healthy controls. miR155 had the highest expression level of these six UC associated miRNAs in peripheral blood.…”

Section: Mirnas In Ucmentioning

confidence: 99%

“…miRNAs in peripheral blood: Apart from assessing miRNA expressions in peripheral blood in UC, Paraskevi et al [125] examined miRNA expression patterns in peripheral blood samples from 128 patients with active CD and 162 healthy individuals. Eleven miRNAs (miR16, miR23a, miR29a, miR106a, miR107, miR126, miR191, miR199a5p, miR200c, miR 3623p, and miR5323p) were markedly upregulated in peripheral blood from CD patients as compared with healthy individuals.…”

Section: Mirnas In CDmentioning

confidence: 99%

miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation

Zhang

2016

WJG

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammatory disorders of the gastrointestinal tract, and includes two major phenotypes: ulcerative colitis and Crohn's disease. The pathogenesis of IBD is not fully understood as of yet. It is believed that IBD results from complicated interactions between environmental factors, genetic predisposition, and immune disorders. miRNAs are a class of small non-coding RNAs that can regulate gene expression by targeting the 3′-untranslated region of specific mRNAs for degradation or translational inhibition. miRNAs are considered to play crucial regulatory roles in many biologic processes, such as immune cellular differentiation, proliferation, and apoptosis, and maintenance of immune homeostasis. Recently, aberrant expression of miRNAs was revealed to play an important role in autoimmune diseases, including IBD. In this review, we discuss the current understanding of how miRNAs regulate autoimmunity and inflammation by affecting the differentiation, maturation, and function of various immune cells. In particular, we focus on describing specific miRNA expression profiles in tissues and peripheral blood that may be associated with the pathogenesis of IBD. In addition, we summarize the opportunities for utilizing miRNAs as new biomarkers and as potential therapeutic targets in IBD.

show abstract

Circulating MicroRNA in inflammatory bowel disease

Abstract: Our results suggest that several miRNAs could distinguish CD from UC by real-time PCR. This further highlights the putative role of miRNAs as contributors to IBD pathogenesis. They may help develop new non-invasive biomarkers to distinguish UC and CD.

Cited by 222 publications

References 24 publications

Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

Upregulation of Gingival Tissue miR-200b in Obese Periodontitis Subjects

The emerging role of miRNAs in inflammatory bowel disease: a review

miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation

Contact Info

Product

Resources

About