Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia

Grasso, Margherita; Puopolo, Maria; D'Acunto, Emanuela; Talarico, Giuseppina; Crestini, Alessio; Gasparini, Marina; Campopiano, Rosa; Gambardella, Stefano; Castellano, Anna Elisa; Bruno, Giuseppe; Denti, Michela Alessandra; Confaloni, Annamaria

doi:10.3233/jad-180364

Cited by 55 publications

(49 citation statements)

References 64 publications

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“…However, the clinical significance and role of miR‐127‐3p in the osseous metastasis of PCa remains highly unexplored. Previous studies have demonstrated that the dysregulation of miR‐127‐3p is involved in several diseases, such as pituitary oncocytoma, multiple sclerosis, recurrent miscarriage, doxorubicin‐induced cardiotoxicity, frontotemporal dementia, adenovirus‐infected pneumonia, and primary myelofibrosis . For tumors, many studies have indicated that miR‐127‐3p may serve as either a tumor activator or a suppressor depending on the cancer type.…”

Section: Discussionmentioning

confidence: 99%

Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5

Fan

Zhang

et al. 2019

FEBS Letters

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Prostate cancer (PCa) is one of the most common cancers in males and particularly tends to metastasize to bone. Currently, metastatic bone disease is incurable, and new therapies need to be developed. Our study aims to determine the role of miR‐127‐3p in PCa metastasis to bone. The results demonstrate that miR‐127‐3p is markedly reduced in bone metastasis‐positive PCa tissues relative to that in bone metastasis‐negative PCa tissues. Furthermore, overexpressing miR‐127‐3p inhibits PCa cell invasion and migration in vitro by targeting the proteasome β‐subunit PSMB5. Moreover, CCCTC‐binding factor (CTCF) transcriptionally inhibits miR‐127‐3p by interacting with the miR‐127‐3p promoter. Collectively, this study uncovers a novel mechanism of the CTCF/miR‐127‐3p/PSMB5 axis in promoting PCa bone metastasis, indicating that miR‐127‐3p could function as a promising therapeutic target against bone metastasis.

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Section: Discussionmentioning

confidence: 99%

Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5

Fan

Zhang

et al. 2019

FEBS Letters

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“…As a large class of regulatory non-coding RNA molecules, microRNAs (miRNAs) have been considered to be an important post-transcriptional regulator of many biological processes containing cell growth, proliferation, tissue differentiation, embryonic development and apoptosis [11,12]. Moreover, the high stability of miRNAs in blood and tissues has been con rmed, and many circulating miRNAs have been used for non-invasive detection and treatment of many diseases [13,14]. Fu X et al have studied the role of miR-129-5p in obese individuals, and found that miR-129-5p is highly expressed in both obese individuals and animal models, and obesity is known to be the risk factor for the occurrence of NAFLD [15].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Dysregulation of miR-129-5p in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance

Zhang

Niu

Liang

et al. 2020

Preprint

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Background: Non-alcoholic fatty liver (NAFLD) is the hepatic manifestation of metabolic syndromes, insulin resistance (IR) is related to the occurrence of NAFLD. The purpose of this study was to evaluate the expression of miR-129-5p in NAFLD patients and its clinical value, and explore its regulatory effect on IR.Methods: 117 NAFLD patients and 110 healthy controls were included. The levels of miR-129-5p were detected by qRT-PCR. To assess the diagnostic value of miR-129-5p for NAFLD, the receiver operating characteristic curve (ROC) was established. C57Bl/6 mice were supplied with high-fat diet to establish NAFLD model. Intraperitoneal insulin tolerance test (IPITT) was carried out to evaluate the effect of miR-129-5p on IR in NAFLD animal model.Results: miR-129-5p was highly expressed in the serum of NAFLD patients, and patients with HOMA-IR ≥ 2.5 had higher level of miR-129-5p than those with HOMA-IR < 2.5. miR-129-5p had the ability to differentiate NAFLD patients from healthy individuals, and might be associated with the development of IR. Serum miR-129-5p was positively correlated with the levels of HOMA-IR, BMI, total cholesterol (TC) and triglyceride (TG) in NAFLD patients. Downregulation of miR-129-5p regulates lipid metabolism and insulin sensitivity in NAFLD mice model.Conclusions: MiR-129-5p was up-regulated in NAFLD patients, and might be a potential diagnostic biomarker. The regulatory effect of miR-129-5p on NAFLD may function by regulating lipid accumulation and insulin sensitivity.

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“…The clinical value for the identification and validation of such non-coding RNAs is the revelation of novel drug targets for future translational medicine therapeutic approaches. However, since both miRNAs and lncRNAs are also present within circulating and isolated body fluids, these can also act as diagnostic and disease-stratifying biomarkers for dementia through basic liquid biopsies such as blood sampling [ [108] , [109] , [110] , [111] , [112] , [113] ].…”

Section: Discussionmentioning

confidence: 99%

Non-coding RNA influences in dementia

Ayers

Scerri

2018

Non-coding RNA Research

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Dementia is a complex clinical syndrome characterised by progressive decline in cognitive function. It usually presents itself as impairment in memory, loss of judgement, abstract thinking and other disturbances that are severe enough to interfere with activities of daily living. It has long been considered as one of the major challenges at present posing an ever-increasing demand on global health and social care systems. Of all the different forms of dementia, Alzheimer's disease (AD) is the most common. The term non-coding RNA (ncRNA) refers to RNA sequences which do not have the ability to be translated into proteins and therefore mainly fall within the realm of the recently acknowledged ‘dark matter’ of the genome. This genomic dark matter encompasses a whole spectrum of differing ncRNA families such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), PIWI-interacting RNAs (piRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snoRNAs) and circular RNAs (circRNAs), to name but a few. Consequently, due to the widespread influences of miRNAs and lncRNAs across all disease pathways, it is of critical importance for researchers in the field of dementia to focus their attention on possible ncRNA-induced pathogeneses, with the ultimate goal of identifying novel diagnostic procedures and drug targets, together with the development of novel therapies to control such a devastating mental condition in the patient population.

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Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia

Cited by 55 publications

References 64 publications

Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5

Transcriptional downregulation of miR‐127‐3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5

WITHDRAWN: Dysregulation of miR-129-5p in Patients with Non-Alcoholic Fatty Liver Disease and Its Regulatory Effect on Insulin Resistance

Non-coding RNA influences in dementia

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