Circulating miR‐26a and miR‐21 as biomarkers for glioblastoma multiform

ParvizHamidi, Monireh; Haddad, Ghazal; Ostadrahimi, Shiva; Ostadrahimi, Nima; Sadeghi, Sedigheh; Fayaz, Shima; Fard-Esfahani, Pezhman

doi:10.1002/bab.1707

Cited by 36 publications

(25 citation statements)

References 26 publications

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“…Five miRNAs were found to be involved in MGMT alterations and tumor suppressor functions of TP53 (miR-21, miR-125b, miR-34a, miR-181d, and miR-648) in GBM progression ( 38 ). In particular, miR-21 and miR-181d were associated with GBM tumorigenesis ( 39 – 42 ), as have a number of other miRNAs, miR-144 and miR-29a ( 43 – 45 ). These miRNAs may prove to be important biomarkers for GBM, but their specificity needs to be further validated.…”

Section: Genomic Landscape Of the Gbm Microenvironmentmentioning

confidence: 99%

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma

et al. 2020

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Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor prognosis, despite surgical resection combined with radio- and chemotherapy. The major clinical obstacles contributing to poor GBM prognosis are late diagnosis, diffuse infiltration, pseudo-palisading necrosis, microvascular proliferation, and resistance to conventional therapy. These challenges are further compounded by extensive inter- and intra-tumor heterogeneity and the dynamic plasticity of GBM cells. The complex heterogeneous nature of GBM cells is facilitated by the local inflammatory tumor microenvironment, which mostly induces tumor aggressiveness and drug resistance. An immunosuppressive tumor microenvironment of GBM provides multiple pathways for tumor immune evasion. Infiltrating immune cells, mostly tumor-associated macrophages, comprise much of the non-neoplastic population in GBM. Further understanding of the immune microenvironment of GBM is essential to make advances in the development of immunotherapeutics. Recently, whole-genome sequencing, epigenomics and transcriptional profiling have significantly helped improve the prognostic and therapeutic outcomes of GBM patients. Here, we discuss recent genomic advances, the role of innate and adaptive immune mechanisms, and the presence of an established immunosuppressive GBM microenvironment that suppresses and/or prevents the anti-tumor host response.

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Section: Genomic Landscape Of the Gbm Microenvironmentmentioning

confidence: 99%

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma

et al. 2020

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“…We selected miR-20a and miR-26a for analysis based on previous impellent studies which described the importance of these miRNAs in cancers (ParvizHamidi et al, 2018;Xu et al, 2018). For example there are studies expressed that miR-20a regulates cell growth and plays important roles in prostate and other cancers initiation and progression (O'donnell et al, 2005;Pesta et al, 2010;Liu et al, 2012;Xu et al, 2018;Zhang et al, 2018).…”

Section: Circulating Mir-20a and Mir-26a As Biomarkers In Prostate Camentioning

confidence: 99%

Circulating miR-20a and miR-26a as Biomarkers in Prostate Cancer

Torbati

Asadi

Fard-Esfahani

2019

Asian Pac J Cancer Prev

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unrevealed overwhelming need for investigation on new biomarkers which can prevail these weak points and make early diagnosis feasible.MicroRNAs (miRNAs) are a cluster of non-coding, endogenous and small RNA molecules which have important functions in regulation of various biological processes such as proliferation, differentiation, apoptosis, AbstractObjective: Circulating microRNAs (miRNAs), present in body fluids, have been considering importance as cancer biomarkers. The primary aim of this study was to assess whether circulatory miR-20a and miR-26a can be used as diagnostic biomarkers in prostate cancer (PCa). Methods: Relative expression miR-20a and miR-26a has been assessed in 40 patients with PCa and 40 non-cancerous volunteer. Sample Collection of patients was performed before and one week after prostatectomy. Total RNA was extracted from serum and miR-20a and miR-26a expressions were quantified by using Real-Time PCR method. Results: miR-20a was significantly up-regulated in pre-operation serum samples of PCa patients compared to the serum samples of non-cancerous controls, however, in post-operation samples no significant differences was showed. miR-26a level was not significantly decreased in pre and post-operation serum samples compared to the serum samples of controls. However, the expression level ratios of both miR-20a and miR-26a were insignificantly decreased when post-operation serum samples compared to pre-operation ones. Conclusion: Decrement of circulating miR-20a and miR-26a in patients after surgery may reflect the tumoral origin of those microRNAs and the results may use for tumor remnant monitoring after prostatectomy.

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“…The first evidence that miRNAs can be found also in extracellular body fluids, incorporated into microvesicles, or bound to specific RNA-binding proteins, came from Skog et al [45]. This study paved the way for the use of miRNAs as potential non-invasive diagnostic biomarkers for GBM [46][47][48][49][50][51]. The involvement of miRNAs in GBM cell resistance to chemotherapy was first reported by Li et al [52]; they showed that oncomiR-21 is involved in GBM cell resistance to the chemotherapeutic agent teniposide by targeting LRR binding FLII interacting protein 1 (LRRFIP1) mRNA.…”

Section: Micrornas (Mirnas) Are Extensively Dysregulated In Gbmmentioning

confidence: 97%

Peritumoral Microenvironment in High-Grade Gliomas: From FLAIRectomy to Microglia–Glioma Cross-Talk

et al. 2021

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Cellular composition and molecular signatures of the glioma core compared with infiltrative margins are different, and it is well known that the tumor edge is enriched in microglia. In this review of the literature, we summarize the role of the peritumoral area in high-grade gliomas (HGGs) from surgical and biological points of view. There is evidence on the dual role of microglia in HGGs—a scavenger-tumoricidal role when microglia are activated in an M1 phenotype and a role favoring tumor growth and infiltration/migration when microglia are activated in an M2 phenotype. Microglia polarization is mediated by complex pathways involving cross-talk with glioma cells. In this scenario, extracellular vesicles and their miRNA cargo seem to play a central role. The switch to a specific phenotype correlates with prognosis and the pathological assessment of a specific microglial setting can predict a patient’s outcome. Some authors have designed an engineered microglial cell as a biologically active vehicle for the delivery of intraoperative near-infrared fluorescent dye with the aim of helping surgeons detect peritumoral infiltrated areas during resection. Furthermore, the pharmacological modulation of microglia-glioma cross-talk paves the way to more effective therapies.

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Circulating miR‐26a and miR‐21 as biomarkers for glioblastoma multiform

Cited by 36 publications

References 26 publications

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma

Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma

Circulating miR-20a and miR-26a as Biomarkers in Prostate Cancer

Peritumoral Microenvironment in High-Grade Gliomas: From FLAIRectomy to Microglia–Glioma Cross-Talk

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