Circulating miRNAs as potential biomarkers for light intensity exercise-induced enhancements in empathy

Shima, Takeru; Kawabata-Iwakawa, Reika; Onishi, Hayate; Yoshikawa, Tomonori; Yoshii, Keisuke; Yoshikawa, Yuika

doi:10.1007/s11332-023-01111-6

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…Furthermore, fatty acids can promote angiogenesis the formation of new blood vessels, thereby facilitating the restoration of blood flow at the burn site. According to the findings of this study, during mild exercise, 106 miR‐122, by regulating the enzyme 1‐acyl‐sn‐glycerol‐3‐phosphate acyltransferase, has the potential to positively modulate the utilization of fatty acids within endothelial cells, thereby promoting angiogenesis 107 …”

Section: Resultsmentioning

confidence: 88%

A systematic review of the exercise effects on burn wound healing

Niumanlan,

Jingming,

Hao

et al. 2023

International Wound Journal

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The emerging evidence has indicated the role of microRNAs (miRNA) in various physiological or pathological processes. Also, documents have suggested that exercise, by affecting miRNA regulation, may enhance burn wound healing. The current study aims to systematically review the role of exercise in regulating miRNAs related to burn wound healing to provide potential therapeutic targets. A comprehensive, systematic search was performed in different international electronic databases, such as Embase, PubMed and Google Scholar search engine, Science Direct, ProQuest and Ovid using keywords extracted from Medical Subject Headings from 2010 to September 2023. The keywords, including ‘exercise’ AND ‘burn wound’ AND ‘microRNA’ and finally, six cases were achieved. Evidence has indicated that exercise may promote the healing of burn wounds by regulating certain miRNAs. Studies have found that exercise regulates the expression of miRNAs such as mir‐155, miR‐21, let‐7a, miR‐146a, miR‐122 and mir‐210 in burn wound tissue, which regulate inflammation and angiogenesis. These findings suggest that miRNAs may play a role in the positive effect of exercise on burn wound healing. However, further research is needed to understand the mechanisms involved fully.

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Section: Resultsmentioning

confidence: 88%

A systematic review of the exercise effects on burn wound healing

Niumanlan,

Jingming,

Hao

et al. 2023

International Wound Journal

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“…Thus, the restoration of miR-200a-3p levels in the hippocampus may contribute to the amelioration of memory dysfunction and the enhancement of hippocampal MCT2 expressions in T2DM through the modulation of mRNA levels in Keap1 and Pten . Furthermore, a previous study has indicated that 4 weeks of light-intensity exercise did not significantly alter circulating miR-200a-3p levels in healthy mice [42]; however, the impact of such exercise intervention on circulating miR-200a-3p levels in T2DM mice remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Muscle-derived miR-200a-3p through light-intensity exercise may contribute to improve memory dysfunction in type 2 diabetic mice

Shima,

Onishi,

Terashima

2024

Preprint

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Background: Memory dysfunction associated with type 2 diabetes mellitus (T2DM) poses a considerable threat to overall well-being. Engaging in light-intensity exercise has been shown to exert favorable effects on hippocampal function and molecular profiles, including Mct2 mRNA and miR-200a-3p. Nonetheless, a comprehensive understanding of the mechanisms underlying the positive impact of light-intensity exercise remains elusive. Here, we assessed the influence of exosomal miR-200a-3p secretion from gastrocnemius muscles in T2DM mice undergoing light-intensity exercise intervention, focusing on its potential to ameliorate memory dysfunction. Basic procedures: We initially assessed the effects of light-intensity exercise (7.0 m/min for healthy mice, 5.0 m/min for ob/ob mice, 30 min/day, five days/week, over a four-week period) on memory function, hippocampal mRNA associated with memory function, and the secretion of exosomal miR-200a-3p from their gastrocnemius muscle. Subsequently, the impact of a daily intraperitoneal injection of the miR-200a-3p mimic over a four-week duration was investigated, focusing on its influence on hippocampal dysregulation in ob/ob mice. Main findings: The light-intensity exercise intervention increased gastrocnemius muscle-derived and plasma exosomal miR-200a-3p levels in ob/ob mice, concomitant with improved memory dysfunction. Intriguingly, the daily intraperitoneal injection of mmu-miR-200a-3p mimic also demonstrated an ameliorative effect on memory function in ob/ob mice. Notably, both the exercise intervention and miR-200a-3p mimic treatment induced downregulation in hippocampal Keap1 mRNA and upregulation in mRNA of Hsp90aa1 and Mct2 in ob/ob mice. Principal conclusions: The current results imply that the augmentation of exosomal miR-200a-3p derived from the gastrocnemius muscle contributes to the amelioration of memory dysfunction in T2DM undergoing light-intensity exercise. Additionally, it is proposed that miR-200a-3p emulates the effects of light-intensity exercise, suggesting a potential therapeutic pathway for addressing hippocampal complications in the context of T2DM.

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The potential contribution of light-intensity exercise-induced miR-486a-3p secretion on enhancing empathic behavior in mice

Shima,

Yoshii,

Yoshikawa

et al. 2024

Preprint

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Empathy plays a crucial role in the maintenance of interpersonal relationships among mammals. Remarkably, engaging in light-intensity exercise has been identified as a facilitator of empathic behavior, a phenomenon associated with the upregulation of miR-486a-3p in the insular cortex. However, it remains to cover the contribution of miR-486a-3p and the mechanisms of changing levels of that in the insular cortex with light-intensity exercise. We initially assessed the impact of light-intensity exercise (7.0 m/min, 30 min/day, five days/week for four weeks) on helping behavior, mRNA in their insular cortex, and the secretion of exosomal miR-486a-3p from their gastrocnemius muscle. Subsequently, we explored the effects of a daily intraperitoneal injection of miR-486a-3p mimic over a two-week period on helping behavior. The intervention of light-intensity exercise, which enhanced helping behavior, resulted in elevated levels of miR-486a-3p in the insular cortex and exosomal miR-486a-3p in the plasma. Interestingly, there was no significant change observed in the levels of gastrocnemius muscle-derived exosomal miR-486a-3p. Moreover, the administration of mmu-miR-486a-3p mimic exhibited a similar enhancement of helping behavior in mice. Notably, both the exercise intervention and miR-486a-3p mimic treatment led to the downregulation of Pten mRNA and upregulation of Bdnf mRNA in the insular cortex. Our findings suggest that the increase in exosomal miR-486a-3p, originating from a source other than the gastrocnemius muscle, contributes to the empathy enhancement induced by light-intensity exercise. Furthermore, it is proposed that miR-486a-3p mimics the effects of light-intensity exercise, presenting a potential avenue for treating empathy-related behaviors.

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Circulating miRNAs as potential biomarkers for light intensity exercise-induced enhancements in empathy

Cited by 3 publications

References 51 publications

A systematic review of the exercise effects on burn wound healing

A systematic review of the exercise effects on burn wound healing

Muscle-derived miR-200a-3p through light-intensity exercise may contribute to improve memory dysfunction in type 2 diabetic mice

The potential contribution of light-intensity exercise-induced miR-486a-3p secretion on enhancing empathic behavior in mice

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