Circulating monocyte subsets and cardio - vascular risk factors in coronary artery disease

Hristov, Mihail; Leyendecker, T.; Schuhmann, Christoph; Hundelshausen, Philipp von; Heussen, Nicole; Kehmeier, Eva; Krötz, Florian; Sohn, Hae-Young; Klauß, Volker; Weber, Christian

doi:10.1160/th10-01-0069

Cited by 39 publications

(43 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At baseline, cell counts of all 3 monocyte subsets were correlated with traditional as well as nontraditional cardiovascular risk factors. Interestingly, CD14ϩϩCD16ϩ monocytes seem particularly to integrate cardiovascular risk burden, a notion that is supported by earlier data (26). Of most interest, CD14ϩϩCD16ϩ monocytes were the only independent predictors of adverse cardiovascular outcomes after full adjustment for traditional and nontraditional cardiovascular risk factors in the HOM SWEET HOMe study.…”

Section: C-statistics Corresponding To the Cox Regression Analyses Resupporting

confidence: 56%

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Rogačev

Cremers

Zawada

et al. 2012

Journal of the American College of Cardiology

465

192

View full text Add to dashboard Cite

show abstract

Section: C-statistics Corresponding To the Cox Regression Analyses Resupporting

confidence: 56%

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Rogačev

Cremers

Zawada

et al. 2012

Journal of the American College of Cardiology

465

192

View full text Add to dashboard Cite

show abstract

“…17 In patients with stable coronary artery disease, the percentage of CD14 ϩϩ CD16 Ϫ monocytes was elevated in patients with 5 or more risk factors compared with low-to medium-risk patients. 18 Here we show that monocyte subsets measured at baseline can predict incident CVD, also, in a randomly selected population cohort over a median follow-up of 15 years. We also investigate if monocyte subsets are associated with extent of atherosclerosis at baseline by correlating monocyte subsets to intima media thickness in the carotid artery measured by ultrasound.…”

Section: Ccr2mentioning

confidence: 68%

Elevated CD14 ⁺⁺ CD16 ⁻ Monocytes Predict Cardiovascular Events

Berg

Ljungcrantz²,

Andersson³

et al. 2012

Circ Cardiovasc Genet

230

142

View full text Add to dashboard Cite

Background— Although monocytes in peripheral blood are no longer considered to be a homogeneous population, associations between distinct monocyte subsets and cardiovascular disease have not been highlighted in large epidemiological studies. Methods and Results— The study included 700 randomly selected subjects from the cardiovascular arm of the Malmö Diet and Cancer study. Among these, 123 subjects experienced ischemic cardiovascular events during the follow-up until December 2008. Mononuclear leukocytes frozen at the baseline investigation in 1991 to 1994 were thawed and analyzed with flow cytometry to enumerate monocyte subsets, based on CD14 and CD16 expression. The percentage and number of classical CD14 ++ CD16 − monocytes were increased in the cardiovascular-event group compared with the event-free subjects (median, 69% [interquartile range, 62% to 76%] versus 67% [59% to 72%], P =0.017; 344 [251 to 419] cells/μL versus 297 [212 to 384] cells/μL, P =0.003). The hazard ratio was 1.66 for suffering a cardiovascular event in the highest tertile of the number of CD14 ++ CD16 − monocytes compared with the lowest tertile, even after adjustment for common risk factors (HR, 1.66; 95% CI: 1.02 to 2.72). CD14 ++ CD16 − monocytes did not, however, associate with the extent of atherosclerosis at baseline. In contrast, the percentage of monocytes expressing CD16 was negatively associated to the extent of carotid atherosclerosis measured as intima-media thickness at baseline. The chemokine receptors CCR2, CX3CR1, and CCR5 were not differentially expressed between cases and controls on any of the monocyte subsets, but CCR5 expression on CD14 + CD16 ++ monocytes was negatively associated to carotid intima-media thickness. Conclusions— This study shows that classical CD14 ++ CD16 − monocytes can predict future cardiovascular risk independently of other risk factors in a randomly selected population.

show abstract

“…The accumulation of such cells in peripheral blood mainly functioned in inducing and perpetuating the inflammatory process in patients with acute and chronic inflammatory diseases. Some studies [29][30][31] have shown that CD16 + monocyte counts are elevated in many inflammatory conditions and that CD16 + monocytes are efficient producers of inflammatory cytokines with high endothelial affinity.…”

Section: Discussionmentioning

confidence: 99%

Intermediate Monocytes Lead to Enhanced Myocardial Remodelling in STEMI Patients With Diabetes

Zhang

2015

Int. Heart J.

View full text Add to dashboard Cite

SummaryThis study aimed to evaluate the potential associations of intermediate monocytes (CD14 ++ CD16 + ) with myocardial remodelling in ST segment elevation myocardial infarction (STEMI) patients with diabetes.A total of 67 STEMI patients with diabetes were enrolled. The control group consisted of 65 STEMI patients without diabetes. All patients received emergency medical services for reperfusion therapy in less than 12 hours after onset of AMI. Blinded to patient clinical characteristics, monocyte subset analysis was performed using flow cytometry immediately after admission. mRNA of Chemokine Decoy Receptor D6 in each subset of monocytes was validated by Q-PCR. Expression of CCL2 in patient plasma was determined with an Elisa kit. Infarct size and left ventricular ejection fraction (LVEF) were measured using 3-dimensional echocardiography 3 days and 6 months after AMI. The incidences of recurrent cardiovascular events and death in each group were measured using the Kaplan-Meier estimator in follow-up during the next 24 months. Cox proportional-hazard models were further used to analyze the relationship of monocyte cell counts and event-free survival after adjusting for confounding factors.The number of circulating intermediate monocytes was significantly correlated with LVEF% and infarct size (r = -0.32; P = 0.008; r = 0.57, P < 0.001) in STEMI patients with diabetes compared with those without diabetes 6 months after AMI. Chemokine Decoy Receptor D6 transcript levels were lower in intermediate monocytes of STEMI patients with diabetes compared to the subsets in STEMI patients without diabetes (P < 0.001). Higher levels of CCL2 (pg/mL) were observed in STEMI patients with diabetes compared to STEMI patients without diabetes (P < 0.001). During a mean follow-up period of 24 ± 1 month, recurrent cardiovascular events or death occurred in 23 patients belonging to the STEMI with diabetes group and 10 belonging to the control group. Univariate Kaplan-Meier analysis revealed that counts of the intermediate monocytes according to median showed statistical significance in STEMI patients with diabetes (P = 0.010). After full adjustment for confounding factors, the cells were found to remain independently related to recurrent cardiovascular events or death in this group (P = 0.004, 95% CI: 1.62-12.49).Intermediate monocytes were associated with LV remodelling in STEMI patients with diabetes. The cells were predictive for recurrent cardiovascular events or death in these patients. A low level of D6 mRNA in the intermediate monocytes of STEMI patients with diabetes and high level of CCL2 in these patients may partially explain the causality. (Int Heart J 2015; 56: 22-28)

show abstract

Circulating monocyte subsets and cardio - vascular risk factors in coronary artery disease

Cited by 39 publications

References 12 publications

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Elevated CD14 ⁺⁺ CD16 ⁻ Monocytes Predict Cardiovascular Events

Intermediate Monocytes Lead to Enhanced Myocardial Remodelling in STEMI Patients With Diabetes

Contact Info

Product

Resources

About

Circulating monocyte subsets and cardio - vascular risk factors in coronary artery disease

Cited by 39 publications

References 12 publications

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Elevated CD14 ++ CD16 − Monocytes Predict Cardiovascular Events

Intermediate Monocytes Lead to Enhanced Myocardial Remodelling in STEMI Patients With Diabetes

Contact Info

Product

Resources

About

Elevated CD14 ⁺⁺ CD16 ⁻ Monocytes Predict Cardiovascular Events