Circulating Non-coding RNAs and Cardiovascular Diseases

Zhao, Chenglin; Lv, Yicheng; Duan, Yi; Li, Guoping; Zhang, Zhongrong

doi:10.1007/978-981-15-1671-9_22

Cited by 9 publications

(9 citation statements)

References 95 publications

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“…This review focuses on regulatory noncoding RNAs that are directly or indirectl responsive to flow and their involvement with cardiovascular effects of altered bloo flow, with a focus on the potential clinical relevance and the underlying molecular mech anisms and their possible use as clinical biomarkers [71]. As relevant evidence is no equally available for all ncRNAs sub-categories, some specific ncRNAs, including siR NAs, snoRNA or piRNA are not mentioned in this review due to lack of evidence in rela Noncoding RNAs are largely involved in cardiovascular physiology, atherosclerosis [35], and multiple cardiovascular diseases [36], as chronic and acute coronary syndromes [6,[37][38][39][40][41], vascular remodeling [29,42], valvular heart disease [43][44][45][46][47], generation and progression of ectopic calcifications in the cardiovascular system [48][49][50][51][52][53][54], platelet function [55][56][57][58][59], heart failure and stroke [60][61][62][63][64][65][66][67][68][69][70].…”

Section: Noncoding Rnasmentioning

confidence: 99%

“…This review focuses on regulatory noncoding RNAs that are directly or indirectly responsive to flow and their involvement with cardiovascular effects of altered blood flow, with a focus on the potential clinical relevance and the underlying molecular mechanisms and their possible use as clinical biomarkers [71]. As relevant evidence is not equally available for all ncRNAs sub-categories, some specific ncRNAs, including siRNAs, snoRNA or piRNA are not mentioned in this review due to lack of evidence in relation to flow conditions.…”

Section: Noncoding Rnasmentioning

confidence: 99%

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Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Rosa

Iaconetti

Eyileten

et al. 2022

JCM

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The vascular system is largely exposed to the effect of changing flow conditions. Vascular cells can sense flow and its changes. Flow sensing is of pivotal importance for vascular remodeling. In fact, it influences the development and progression of atherosclerosis, controls its location and has a major influx on the development of local complications. Despite its importance, the research community has traditionally paid scarce attention to studying the association between different flow conditions and vascular biology. More recently, a growing body of evidence has been accumulating, revealing that ncRNAs play a key role in the modulation of several biological processes linking flow-sensing to vascular pathophysiology. This review summarizes the most relevant evidence on ncRNAs that are directly or indirectly responsive to flow conditions to the benefit of the clinician, with a focus on the underpinning mechanisms and their potential application as disease biomarkers.

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Section: Noncoding Rnasmentioning

confidence: 99%

Section: Noncoding Rnasmentioning

confidence: 99%

Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Rosa

Iaconetti

Eyileten

et al. 2022

JCM

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“…Noncoding RNAs (ncRNAs) are considered major players in physiological and pathological processes based on their versatile regulatory roles in different diseases, including cardiovascular disease. [5,6] Circular RNAs (circRNAs) are a subtype of endogenous ncRNAs, constitute a substantial fraction of the mammalian transcriptome, [7] and are abundantly expressed in the cardiovascular system. [8,9] The circRNAs that function as competing endogenous RNA (ceRNA) have been most extensively studied in I/R injury.…”

Section: Introductionmentioning

confidence: 99%

Circ‐CBFB exacerbates hypoxia/reoxygenation‐triggered cardiomyocyte injury via regulating miR‐495‐3p in a VDAC1‐dependent manner

Chen

Han

Pang³

et al. 2022

J Biochem & Molecular Tox

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A large body of literature has identified that circular RNAs play critical roles in regulating the occurrence and development of cardiovascular disease. In the present study, we intended to provide new ideas and perspectives on the functional role of circ‐CBFB in hypoxia/reoxygenation (H/R)‐injured cardiomyocytes. We observed that circ‐CBFB expression was enhanced which was accompanied by a miR‐495‐3p reduction in response to H/R exposure. Functionally, deletion of circ‐CBFB obviously potentiated cell viability and restrained cell apoptosis, which was accompanied by a remarkable elevation of antiapoptotic Bcl‐2 but the repression of proapoptotic Bax and cleaved caspase‐3 in response to H/R. Additionally, the absence of circ‐CBFB dramatically prohibited H/R‐evoked cardiomyocyte oxidative stress, as revealed by a decrease in reactive oxygen species overproduction, diminution in MAD content, and enhancement in SOD, CAT, and GSH‐Px activities. Moreover, elimination of circ‐CBFB resulted in improvement of mitochondrial dysfunction, as assessed by mitochondrial membrane potential, adenosine triphosphate production, and the release of cyto‐c. Interestingly, circ‐CBFB inversely regulated miR‐495‐3p expression via acting as a competing endogenous RNA. VDAC1 was identified to be a functional target of miR‐495‐3p and positively modulated by circ‐CBFB. Mechanically, dissipation of miR‐495‐3p or augmentation of VDAC1 manifestly counteracted the beneficial effects of circ‐CBFB knockdown on H/R‐elicited cardiomyocyte insult. Collectively, these observations demonstrated that absence of circ‐CBFB offered cardio‐protection against H/R‐triggered cardiomyocyte injury by relieving apoptosis, oxidative stress, and mitochondria dysfunction through miR‐495‐3p/VDAC1 axis. This work unveiled an innovative axis of circ‐CBFB/miR‐495‐3p/VDAC1 in H/R‐challenged cardiomyocyte damage, exerting its potential in providing new thoughts in acute myocardial infarction management.

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“…Circulating miRNAs are associated with vesicles (exosomes, microparticles and apoptotic bodies), protein complexes (Ago2, NPM1) and lipoprotein complexes (HDL, LDL complexes) 7,8 . Circulating miRNAs are regarded as promising noninvasive biomarkers for risk stratification, diagnosis and prognosis of various cardiometabolic diseases 9–12 . In addition, circulating miRNAs are mediators of intercellular signalling 13 .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Circulating miRNAs are regarded as promising noninvasive biomarkers for risk stratification, diagnosis and prognosis of various cardiometabolic diseases. [9][10][11][12] In addition, circulating miRNAs are mediators of intercellular signalling. 13 It has been proposed that circulating miRNAs behave like hormones in intercellular communications.…”

mentioning

confidence: 99%

Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects

Thibonnier

Ghosh

Blanchard

2021

J Cellular Molecular Medi

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This discovery study investigated in healthy subjects whether a short‐term cold exposure may alter circulating microRNAs and metabolic parameters and if co‐expression networks between these factors could be identified. This open randomized crossover (cold vs no cold exposure) study with blind end‐ point evaluation was conducted at 1 center with 10 healthy adult male volunteers. Wearing a cooling vest perfused at 14°C for 2 h reduced the local skin temperature without triggering shivering, increased norepinephrine and blood pressure while decreasing copeptin, C‐peptide and heart rate. Circulating microRNAs measured before and after wearing the cooling vest twice (4 time points) identified 196 mature microRNAs with excellent reproducibility over 72 h. Significant correlations of microRNA expression with copeptin, norepinephrine and C‐peptide were found. A co‐expression‐based microRNA‐microRNA network, as well as microRNA pairs displaying differential correlation as a function of temperature were also detected. This study demonstrates that circulating miRNAs are differentially expressed and coregulated upon cold exposure in humans, supporting their use as predictive and dynamic biomarkers of cardio‐metabolic disorders.

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Circulating Non-coding RNAs and Cardiovascular Diseases

Cited by 9 publications

References 95 publications

Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Circ‐CBFB exacerbates hypoxia/reoxygenation‐triggered cardiomyocyte injury via regulating miR‐495‐3p in a VDAC1‐dependent manner

Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects

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