Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or <i>β</i>-Cell Function in Chinese Obese Children

Wang, Fengyun; Chen, Ting; Lv, Haitao; Li, Xuan; Shen, Jie; Chen, Linqi; Chu, Zhenyu; Miao, Heng

doi:10.1155/2018/3729402

Cited by 7 publications

(6 citation statements)

References 31 publications

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“…One of the hypotheses suggests that obesity may represent a state of chronic oxidative stress and low-grade inflammation. 7,14 The results are in agreement with the previous studies, we also found that the level of hsCRP in obesity participants were significantly higher than nonobesity group, 15,16 and vitamins may reduce the risk of obesity by…”

Section: Discussionsupporting

confidence: 92%

Association between vitamin levels and obesity in the national health and nutrition examination surveys 2017 to 2018

Lu,

Sun

2023

J Dev Orig Health Dis

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In recent years, the rapidly increasing incidence of obesity is becoming a worldwide public health problem. Obesity is a chronic disease which may have a major negative effect on the people’s quality of life. Previous studies on the comprehensive effects of multivitamins on central obesity and general obesity are relatively few. The aim of this study was to evaluate association of vitamins exposure with obesity risk and obesity-related indicators. We fitted three statistical models (linear regression model, logistic regression model, and Bayesian kernel machine regression model) to evaluate the correlation between vitamin levels and obesity in the study population. The vitamin score represents the overall level of vitamin in serum, which was mutually verified with the results obtained from statistical model. The vitamin (A, C, and D) levels were significantly higher among non-obesity group compared to the obesity group. Using the lowest quartile of vitamin level as a referent, vitamin A, C, and D levels showed significantly negative correlation with the obesity risk in both adjusted and unadjusted models. When considering all vitamin as a mixed exposure, we found a generally negative relationship between vitamin mixtures with binary outcome (obesity) and continuous outcome (BMI, waist circumference, and hsCRP). Reduced levels of vitamins (A, C and D) increased the risk of obesity. Increased levels of vitamin mixtures can significantly reduce obesity risk and obesity-related indicators. Vitamins may reduce the risk of obesity by suppressing inflammatory responses.

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Section: Discussionsupporting

confidence: 92%

Association between vitamin levels and obesity in the national health and nutrition examination surveys 2017 to 2018

Lu,

Sun

2023

J Dev Orig Health Dis

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“…A 180-min OGTT (1.75 g/kg glucose, maximum 75 g) according to the American Diabetes Association criteria was performed in all obese subjects 17. Venous blood samples were obtained by venipuncture after overnight fasting at 0, 30, 60, 120 and 180 mins to measure serum glucose, insulin and CTRP3 levels as described previously 19…”

Section: Methodsmentioning

confidence: 99%

<p>Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic β Cell Function</p>

Chen¹,

Wang²,

Chu³

et al. 2019

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PurposeCTRP3 is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The current study aimed to investigate the potential role of CTRP3 in obese children and explore its relationships with insulin sensitivity, pancreatic β cell function, and obesity-related markers.Patients and methodsWe studied the levels of serum CTRP3 in 48 obese and 36 normal weight pre-puberty children. The levels of blood pressure, lipids, glucose, and insulin were measured, and the values of HOMA-IR, HOMA-β and insulinogenic index were calculated. The correlations of these measurements with CTRP3 levels were analyzed.ResultsIn this study, we found that CTRP3 serum levels significantly decreased in obese children compared to controls, and insulin resistant obese subjects have lower CTRP3 levels in contrast with the non-insulin resistant obese subjects. Moreover, serum CTRP3 concentrations significantly decreased, while glucose and insulin concentrations significantly increased after a 3 hrs oral glucose tolerance test in obese children. Furthermore, Serum CTRP3 levels correlated negatively and significantly with BMI, triglycerides, systolic blood pressure, fasting insulin, glucose, HOMA-IR, HOMA-β and insulinogenic index in obese children.ConclusionIn summary, serum CTRP3 levels significantly decreased in obese children, and negatively correlated with insulin resistance and pancreatic β cell function indicators. Therefore, CTRP3 may play a protective role in the glucose homeostasis and tightly related to β cell function as well as obesity-related markers in obese children.

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“…A growing number of human studies have demonstrated the possible role of PGRN in insulin resistance and obesity, but data are highly controversial. Generally, hyperprogranulinemia has been reported to be linked to adiposity, metabolic parameters, insulin resistance and inflammatory markers both in adult [ 63 ] and childhood obesity [ 64 ]; however, in other studies PGRN has not been found to be associated with insulin sensitivity and beta-cell function [ 65 ]. In obese healthy men, significantly improved body composition and insulin resistance and decreased serum PGRN levels were detected after 8-week circuit resistance training [ 66 ].…”

Section: Role Of Novel Adipokines In Non-diabetic Obesitymentioning

confidence: 99%

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

et al. 2023

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Obesity is characterized by an excessive accumulation of fat leading to a plethora of medical complications, including coronary artery disease, hypertension, type 2 diabetes mellitus or impaired glucose tolerance and dyslipidemia. Formerly, several physiological roles of organokines, including adipokines, hepatokines, myokines and gut hormones have been described in obesity, especially in the regulation of glucose and lipid metabolism, insulin sensitivity, oxidative stress, and low-grade inflammation. The canonical effect of these biologically active peptides and proteins may serve as an intermediate regulatory level that connects the central nervous system and the endocrine, autocrine, and paracrine actions of organs responsible for metabolic and inflammatory processes. Better understanding of the function of this delicately tuned network may provide an explanation for the wide range of obesity phenotypes with remarkable inter-individual differences regarding comorbidities and therapeutic responses. The aim of this review is to demonstrate the role of organokines in the lipid and glucose metabolism focusing on the obese non-diabetic subgroup. We also discuss the latest findings about sarcopenic obesity, which has recently become one of the most relevant metabolic disturbances in the aging population.

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Circulating PGRN Levels Are Increased but Not Associated with Insulin Sensitivity or β-Cell Function in Chinese Obese Children

Cited by 7 publications

References 31 publications

Association between vitamin levels and obesity in the national health and nutrition examination surveys 2017 to 2018

Association between vitamin levels and obesity in the national health and nutrition examination surveys 2017 to 2018

<p>Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic β Cell Function</p>

Crucial Regulatory Role of Organokines in Relation to Metabolic Changes in Non-Diabetic Obesity

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