Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Koupenova, Milka; Clancy, Lauren; Corkrey, Heather A.; Freedman, Jane E.

doi:10.1161/circresaha.117.310795

Cited by 731 publications

(644 citation statements)

References 136 publications

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“…Platelet numbers in a healthy individual are usually maintained at a stable level ranging from 150 to 400 × 10 6 per mL of blood . These levels of platelets vastly exceed the numbers required to mount a normal hemostatic response, and so they are consistent with the idea that the role of platelets in biology extends beyond hemostasis . Within the critical biological process of hemostasis, platelets play a pivotal role in identifying injured or disrupted endothelium lining the vasculature.…”

Section: Introductionmentioning

confidence: 65%

Proteolytic processing of platelet receptors

Gardiner

2018

Research and Practice in Thrombosis and Haemostasis

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Essentials Metalloproteinases regulate release/shedding of bioactive membrane proteins.Shedding is critically important for normal cell function in the vasculature.Levels of platelet receptors GPIb‐IX‐V and GPVI are regulated by metalloproteolytic shedding.The premier platelet sheddases belong to the A Disintegrins And Metalloproteinase (ADAMs) family.Modulating ADAM activity may alter platelet adheso‐signalling receptor density and function. Platelets have a major role in hemostasis and an emerging role in biological processes including inflammation and immunity. Many of these processes require platelet adhesion and localization at sites of tissue damage or infection and regulated platelet activation, mediated by platelet adheso‐signalling receptors, glycoprotein (GP) Ib‐IX‐V and GPVI. Work from a number of laboratories has demonstrated that levels of these receptors are closely regulated by metalloproteinases of the A Disintegrin And Metalloproteinase (ADAM) family, primarily ADAM17 and ADAM10. It is becoming increasingly evident that platelets have important roles in innate immunity, inflammation, and in combating infection that extends beyond processes of hemostasis. This overview will examine the molecular events that regulate levels of platelet receptors and then assess ramifications for these events in settings where hemostasis, inflammation, and infection processes are triggered.

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Section: Introductionmentioning

confidence: 65%

Proteolytic processing of platelet receptors

Gardiner

2018

Research and Practice in Thrombosis and Haemostasis

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“…This is believed to have been caused by the platelets natural ability to accumulate at the sites of inflammation induced by the photothermal effects. [ 162 ]…”

Section: Bolstering Cell Membrane Technology With Additional Non‐natimentioning

confidence: 99%

Cell Membrane Nanotherapeutics: From Synthesis to Applications Emerging Tools for Personalized Cancer Therapy

Sevencan

McCoy

Ravisankar

et al. 2020

Advanced Therapeutics

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Over the last decade, researchers have focused on developing an ideal cancer nanomedicine with robust biointerfacing, precise tumor targeting, and effective tumor killing ability. While synthetic approaches have been widely investigated, cell membrane nanotechnology has been attracting growing interest in the nanomedicine field since it enables researchers to exploit the various functions of cells. Prior to development of cell membrane nanotechnology, synthetic cell membrane‐like structures had been employed in nanomedicine. In this review, first a brief comparison between cell membrane and cell membrane‐like structures is provided and the generalized structure and functions of cell membrane are summarized. Cell membrane extraction methods and cell membrane‐based nanoparticle synthesis methods are explained. In addition, applications of these nanotechnologies in many biomedical applications are reviewed. Finally, a perspective of the future prospects and limitations of cell membrane nanotechnology is given. As with many new technologies, there are issues, which when overcome, can allow the potential of cell membrane nanotechnology for future personalized cancer nanomedicine.

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“…Beyond their essential hemostatic function, platelets aid immune defense by mechanisms that are the focus of recent reviews . From an evolutionary perspective, this overlap in function is not surprising, because the roles of platelet and phagocyte are shared by the amoebocyte in the phylogenetically ancient horseshoe crab .…”

Section: Platelets As Agents Of Immunity and Inflammationmentioning

confidence: 99%

Megakaryocytes as immune cells

Cunin

Nigrović

2019

Journal of Leukocyte Biology

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Platelets play well‐recognized roles in inflammation, but their cell of origin—the megakaryocyte—is not typically considered an immune lineage. Megakaryocytes are large polyploid cells most commonly identified in bone marrow. Egress via sinusoids enables migration to the pulmonary capillary bed, where elaboration of platelets can continue. Beyond receptors involved in hemostasis and thrombosis, megakaryocytes express receptors that confer immune sensing capacity, including TLRs and Fc‐γ receptors. They control the proliferation of hematopoietic cells, facilitate neutrophil egress from marrow, possess the capacity to cross‐present antigen, and can promote systemic inflammation through microparticles rich in IL‐1. Megakaryocytes internalize other hematopoietic lineages, especially neutrophils, in an intriguing cell‐in‐cell interaction termed emperipolesis. Together, these observations implicate megakaryocytes as direct participants in inflammation and immunity.

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Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

Cited by 731 publications

References 136 publications

Proteolytic processing of platelet receptors

Proteolytic processing of platelet receptors

Cell Membrane Nanotherapeutics: From Synthesis to Applications Emerging Tools for Personalized Cancer Therapy

Megakaryocytes as immune cells

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