Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions

Sanders, Anne E.; Wallace, E. Diane; Ehrmann, Brandie M.; Soma, Paul S.; Shaikh, Saame Raza; Preisser, John S.; Ohrbach, Richard; Fillingim, Roger B.; Slade, Gary D.

doi:10.1016/j.plefa.2022.102476

Cited by 11 publications

(9 citation statements)

References 45 publications

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“…Specifically, DHA, one of the Omega-3 fatty acids, can reduce inflammation by inhibiting the synthesis of the inflammatory mediator prostaglandin E2 and combating oxidative stress ( 29 , 30 ). Additionally, studies have shown that higher ratios of Omega-6 to Omega-3 fatty acids are associated with an increased risk of cardiovascular disease, autoimmune diseases, and cancer ( 31 , 32 ). Therefore, maintaining a proper balance of omega-3 and Omega-6 fatty acid intake is crucial for maintaining good health.…”

Section: Discussionmentioning

confidence: 99%

Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study

Dai,

Chen,

et al. 2023

Front. Nutr.

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BackgroundObservational studies have indicated an association between polyunsaturated fatty acids (PUFAs) and chronic pain, but the potential causal link remains controversial. Here, we aimed to investigate whether a causal relationship exists between the concentration of circulating PUFAs and chronic pain as well as the direction of this association.MethodsWe collected statistical data from relevant genome-wide association studies to explore the causal link between four PUFAs, along with the ratio of omega-6 fatty acids (FAs) to omega-3 FAs (omega-6:3 ratio), and chronic pain in eight specific body parts. We used the inverse-variance weighting (IVW) method for two-sample Mendelian randomization (MR) analysis and conducted supplementary analyses using four other methods (MR-Egger, weighted median, weighted mode, and simple mode). To verify the robustness of the MR study, we performed multiple sensitivity analyses.ResultsThe results revealed a negative correlation between omega-3 FAs [IVW, OR 95% CI: 0.952 (0.914, 0.991), p = 0.017] and docosahexaenoic acid (DHA) [IVW, OR 95% CI: 0.935 (0.893, 0.978), p = 0.003] with abnormal and pelvic pain. Furthermore, a positive correlation was observed between the omega-6:3 ratio [IVW, OR 95% CI: 1.057 (1.014, 1.101), p = 0.009] with abdominal and pelvic pain. Additionally, we found a negative correlation between omega-3 FAs [IVW, OR 95% CI: 0.947 (0.902, 0.994), p = 0.028] and lower back pain or sciatica. However, no causal relationship was found between the concentration of circulating PUFAs and pain in other body parts, including the face, throat and chest, joints, limbs, lower back, and gynecological parts. The robustness of these MR results was verified through multi-validity and retention method analyses.ConclusionOur analysis suggests that higher circulating concentrations of omega-3 FAs and DHA and a lower omega-6:3 ratio are associated with a reduced risk of abdominal and pelvic pain. Additionally, a higher concentration of circulating omega-3 FAs is linked to a reduced risk of lower back pain and/or sciatica. These findings have major implications for the targeted prevention and treatment of chronic pain using PUFAs.

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Section: Discussionmentioning

confidence: 99%

Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study

Dai,

Chen,

et al. 2023

Front. Nutr.

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“…Analysis was conducted using a Waters Acquity Ultra-Performance Liquid Chromatography system tandem to a ThermoScientific TSQ Vantage as published [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…Table 1 shows detailed information about the LC-MS/MS methodology including retention time (min), precursor ion ( m/z ), product ion ( m/z ), and collision energy (V) for each compound. These parameters were used in the companion article to measure quantities of circulating PUFAs in human erythrocytes [1] . Though the companion article focused on EPA, ALA, DHA, ARA, and LA; the data for all 13 compounds are included in the data repository [2] .…”

Section: Data Descriptionmentioning

confidence: 99%

Dataset linking free polyunsaturated fatty acid concentrations in erythrocytes with chronic pain conditions in adults

et al. 2023

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“…Utilizing the mechanism of nociplastic pain, a fibromyalgia-like mouse model was able to demonstrate that antagonization of the sigma-1 receptor resulted in alleviation long-term nociplastic pain, implicating its potential role in the mechanism [ 63 ]. In an analysis of 605 patients with or without chronic nociplastic pain conditions that commonly overlap (painful temporomandibular disorder, irritable bowel syndrome, fibromyalgia, low back pain, headache), a possible important difference was discovered in the polyunsaturated fatty acid (PUFA) levels [ 64 ]. It was found that a greater omega-6 (n-6) to omega-3 (n-6) PUFA ratio was associated with a greater number of comorbid conditions (i.e., suffered from multiple nociplastic pain conditions).…”

Section: Nociplastic Painmentioning

confidence: 99%

“…These possible biomarkers of nociplastic pain have been previously evidenced to metabolize in the body into pronociceptive oxylipins that increase the risk of hyperalgesia and allodynia [ 65 ]. This metabolism process likely involves lipoxygenase (LOX) or cytochrome P450 enzymes [ 64 ]. One study utilizing a mice model discovered that, unlike neuropathic pain, prostaglandins do not contribute significantly to nociplastic pain [ 66 ].…”

Section: Nociplastic Painmentioning

confidence: 99%

Microbiological and Physiological Effects of Pain

Jin

Everett

Abd‐Elsayed

2023

Curr Pain Headache Rep

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Pain is an important innate defense mechanism that can dramatically alter a person’s quality of life. Understanding the microbiological and physiological effects of pain may be important in the pursuit of novel pain interventions. The three descriptors of pain recognized by the International Association for the Study of Pain are nociceptive, neuropathic, and nociplastic pain. Our review examined the current understanding of all three pain types, focusing on the key molecules involved in the manifestation of each type as well as physiological effects. Additionally, we compared the differences in painful and painless neuropathies and discussed the neuroimmune interaction involved in the manifestation of pain.

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Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions

Cited by 11 publications

References 45 publications

Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study

Causal association of polyunsaturated fatty acids with chronic pain: a two-sample Mendelian randomization study

Dataset linking free polyunsaturated fatty acid concentrations in erythrocytes with chronic pain conditions in adults

Microbiological and Physiological Effects of Pain

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