Circulating Progenitor Cells after Cold Pressor Test in Hypertensive and Uremic Patients

Coppolino, Giuseppe; Bolignano, Davide; Campo, Susanna; Loddo, Saverio; Teti, Diana; Buemi, Michele

doi:10.1291/hypres.31.717

Cited by 28 publications

(18 citation statements)

References 30 publications

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“…E-selectin is a member of the selectin family of cell adhesion molecules, and the intercellular cell adhesion molecule-1 (ICAM-1) and vascular endothelial cell adhesion molecule-1 (VCAM-1) belong to an immunoglobulin super family. The surface expression of these cell adhesion molecules is associated with their shedding into the peripheral circulation [38,39]. Our results confirmed that revascularization induces a rapid increase in endothelial adhesion molecules.…”

Section: Adhesion Molecules Endothelial Activation and Prostanoidssupporting

confidence: 79%

Perioperative Iloprost and Endothelial Progenitor Cells in Uremic Patients With Severe Limb Ischemia Undergoing Peripheral Revascularization

Coppolino

Buemi

Bolignano

et al. 2009

Journal of Surgical Research

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Section: Adhesion Molecules Endothelial Activation and Prostanoidssupporting

confidence: 79%

Perioperative Iloprost and Endothelial Progenitor Cells in Uremic Patients With Severe Limb Ischemia Undergoing Peripheral Revascularization

Coppolino

Buemi

Bolignano

et al. 2009

Journal of Surgical Research

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“…Similarly, others have described decreases in erythropoiesis (11,13), increases in progenitor cell apoptosis (45) and impairment of EPC migration (6,9) caused by uremic toxins present in serum from CKD patients. However, we cannot exclude interference of antihypertensive drugs as confounder in our analysis, since all CKD patients were kept on their regular medication.…”

Section: Discussionmentioning

confidence: 82%

Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease

Krenning¹,

Dankers²,

Drouven³

et al. 2009

American Journal of Physiology-Renal Physiology

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Endothelial progenitor cells (EPC) contribute to repair and maintenance of the vascular system, but in patients with chronic kidney disease (CKD), the number and function of EPC may be affected by kidney dysfunction. We assessed numbers and the angiogenic function of EPC from patients with CKD in relation to disease progression. In a cross-sectional, prospective study, 50 patients with varying degrees of CKD, including 20 patients undergoing dialysis and 10 healthy controls, were included. Mononuclear cells were isolated, and circulating EPC were quantified by flow cytometry based on expression of CD14 and CD34. EPC were cultured on fibronectin-coated supramolecular films of oligocaprolactone under angiogenic conditions to determine their angiogenic capacity and future use in regenerative medicine. CKD patients had normal numbers of circulating CD14+ EPC but reduced numbers of circulating CD34+ EPC. Furthermore, EPC from patients with CKD displayed functional impairments, i.e., hampered adherence, reduced endothelial outgrowth potential, and reduced antithrombogenic function. These impairments were already observed at stage 1 CKD and became more apparent when CKD progressed. Dialysis treatment only partially ameliorated EPC impairments in patients with CKD. In conclusion, EPC number and function decrease with advancing CKD, which may hamper physiological vascular repair and can add to the increased risk for cardiovascular diseases observed in CKD patients.

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“…19 In addition, a physiologic hemodynamic stress, such as dipping hands in icy water (named cold pressor test), was able to rapidly increase progenitor cells. 20 Furthermore, we found elevated numbers of EPCs in patients undergoing HD, reflecting the direct response of bone marrow to hemodynamic stress on vessels. 21 Latest studies have highlighted the potential benefit of PTH on the mobilization of progenitors.…”

Section: Discussionmentioning

confidence: 61%

Parathyroid Hormone and Mobilization of Circulating Bone Marrow-Derived Cells in Uremic Patients

Coppolino

Bolignano²,

Paola³

et al. 2011

Journal of Investigative Medicine

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Circulating Progenitor Cells after Cold Pressor Test in Hypertensive and Uremic Patients

Cited by 28 publications

References 30 publications

Perioperative Iloprost and Endothelial Progenitor Cells in Uremic Patients With Severe Limb Ischemia Undergoing Peripheral Revascularization

Perioperative Iloprost and Endothelial Progenitor Cells in Uremic Patients With Severe Limb Ischemia Undergoing Peripheral Revascularization

Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease

Parathyroid Hormone and Mobilization of Circulating Bone Marrow-Derived Cells in Uremic Patients

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