Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency

Mehta, Anurag; Tahhan, Ayman Samman; Liu, Chang; Dhindsa, Devinder S.; Nayak, Aditi; Hooda, Ananya; Moazzami, Kasra; Islam, Shabatun; Rogers, Steven C.; Almuwaqqat, Zakaria; Mokhtari, Ali Mohammad; Hesaroieh, Iraj; Ko, Yi‐An; Waller, Edmund K.; Quyyumi, Arshed A.

doi:10.1016/j.jacbts.2020.06.006

Cited by 7 publications

(6 citation statements)

References 50 publications

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“…In a 3.5‐year follow‐up study of patients with coronary artery disease, patients with renal insufficiency and low angiogenic CPC counts had an increased risk of cardiovascular events. In contrast, patients with high angiogenic CPC counts showed a similar risk compared to patients without renal insufficiency 34 . Further, in an analysis of individuals from the Framingham Offspring cohort, higher angiogenic CPC numbers were inversely associated with cardiovascular mortality 35 .…”

Section: Discussionmentioning

confidence: 97%

“…In contrast, patients with high angiogenic CPC counts showed a similar risk compared to patients without renal insufficiency. 34 Further, in an analysis of individuals from the Framingham Offspring cohort, higher angiogenic CPC numbers were inversely associated with cardiovascular mortality. 35 Despite these findings more studies are needed to elucidate a potential correlation between the CPC ratio and markers of subclinical cardiovascular damage such as the pulse wave velocity or the left ventricular mass index.…”

Section: Discussionmentioning

confidence: 98%

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Impairment of endothelial progenitor cells in women after kidney transplantation

et al. 2022

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Objective:The long-term survival of kidney transplant patients has substantially improved. However, there is a higher risk for cardiovascular events after transplantation, partly due to immunosuppression. A diminished number of endothelial progenitor cells (EPCs), which play an important role in angiogenesis and the repair of endothelial damage, are associated with an increased cardiovascular risk. The aim of this study was to evaluate whether kidney transplantation affects EPCs in women.Methods: Twenty-four healthy women and 22 female kidney transplant recipients were recruited. The ratio of angiogenic and non-angiogenic circulating progenitor cells (CPCs) was determined by multicolor flow cytometry and related to clinical parameters. Cord blood-derived endothelial colony-forming cells (ECFCs), a proliferative subgroup of endothelial progenitor cells, were treated with pooled sera from transplant patients or healthy controls and tested for their functional integrity using in vitro models.Results: Kidney transplant recipients displayed a reduced ratio of angiogenic and non-angiogenic CPCs compared to healthy controls. Differences were especially pronounced in premenopausal women. Exposure to sera of transplanted women led to a significant impairment of ECFC proliferation, migration, and angiogenesis ability.Conclusions: Alterations of EPC populations may contribute to the higher cardiovascular risks after organ transplantation and should be considered in therapeutic strategies.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Impairment of endothelial progenitor cells in women after kidney transplantation

et al. 2022

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“…Both in ACS and CCS patients, HIST caused a significant reduction of the number of circulating SMPCs. Considering the fact that SMPC are involved in the progression of atherosclerosis after vascular injury [ 35 , 36 ], circulating SMPC reduction due to HIST might reduce neointima hyperplasia and restenosis development and, thus, improve the clinical outcome of patients undergoing PCI.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome

et al. 2022

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Background By low-density lipoprotein (LDL) reduction, statins play an important role in cardiovascular risk modification. Incompletely understood pleiotropic statin effects include vasoprotection that might originate from mobilisation and differentiation of vascular progenitor cells. Data on the potentially differential impact of statin treatment intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention (PCI) are scarce. This study examines the potential association of different permanent statin treatment regimens on circulating progenitor cells in patients with coronary syndrome. Methods and results In a monocentric prospective all-comers study, 105 consecutive cases scheduled for coronary angiography due to either (A) non-invasive proof of ischemia and chronic coronary syndrome (CCS) or (B) troponin-positive acute coronary syndrome (ACS) were included. According to the 2018 American College of Cardiology Guidelines on Blood Cholesterol, patients were clustered depending on their respective permanent statin treatment regimen in either a high- to moderate-intensity statin treatment (HIST) or a low-intensity statin treatment (LIST) group. Baseline characteristics including LDL levels were comparable. From blood drawn at the time of PCI, peripheral blood mononuclear cells were isolated, cultivated and counted and, by density gradient centrifugation, levels of circulating progenitor cells were determined using fluorescence-activated cell sorting (FACS) analysis. In ACS patients both absolute and relative numbers of circulating early-outgrowth endothelial progenitor cells (EPCs) concurrently were significantly lower in the HIST group as compared to the LIST group. This effect was more pronounced in ACS patients than in CCS patients. Both in ACS and CCS patients, HIST caused a significant reduction of the number of circulating SMPCs. Conclusions In patients undergoing PCI, a dose intensity-dependent and LDL level-independent pro-differentiating vasoprotective pleiotropic capacity of statins for EPC and SMPC is demonstrated.

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“…A low number of these CPCs is associated with vascular dysfunction [4,9] and subsequent greater cardiovascular (CV) risk [10,11]. Observational studies have shown that individuals with cardiovascular disease (CVD) exhibit lower number and angiogenic function of these CPCs [12], reflecting reduced vascular repair capacity.…”

Section: Introductionmentioning

confidence: 99%

CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients

2021

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Circulating Progenitor Cells in Patients With Coronary Artery Disease and Renal Insufficiency

Abstract: Visual Abstract

Cited by 7 publications

References 50 publications

Impairment of endothelial progenitor cells in women after kidney transplantation

Impairment of endothelial progenitor cells in women after kidney transplantation

Dose-dependent impact of statin therapy intensity on circulating progenitor cells in patients undergoing percutaneous coronary intervention for the treatment of acute versus chronic coronary syndrome

CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients

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