Circulating serum level of retinoic acid and hip fractures among postmenopausal women

Abstract

PURPOSE The aim of this study was to evaluate the serum levels of retinoic acid (RA), an active form of vitamin A, in postmenopausal women with hip fractures from Zhengzhou, China. METHODS This was a case‐control study from the Affiliated Hospital of Zhengzhou University. Serum samples were drawn from 375 postmenopausal women who were diagnosed as having hip fracture and 750 matched controls without fracture. Serum RA levels were evaluated as both a continuous variable and a categorical variable in quintiles. RESULTS The results showed that the serum levels of RA were significantly (P = .039) higher in patients with hip fracture compared with controls. In univariate and multivariate logistic regression analysis, for each 1 ng/mL increase of serum level of RA, the unadjusted and adjusted risk of hip fracture would be increased by 5% (odds ratio [OR] = 1.05; 95% confidence interval [CI] = 1.00‐1.10; P = .035) and 2% (OR = 1.02; 95% CI = 0.95‐1.11; P = .096), respectively. In multivariate models comparing the fifth with the third quintiles of RA, the RA was associated with hip fracture, and adjusted risk of hip fracture would be increased by 52% (OR = 1.52; 95% CI = 1.13‐1.42; P = .011). CONCLUSIONS The results of our study suggest that subclinical higher levels of RA may increase the risk of hip fracture in postmenopausal women, particularly among the top quintile of serum RA. J Am Geriatr Soc 67:336–341, 2019.

Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

“…The information about age, ethnicities, current tobacco or alcohol use(yes or no), BMI, basic illness (hypertension, diabetes mellitus, cardiovascular disease, neurological disorders, and hyperlipoproteinemia), falls during the last year(yes or no), hip fracture type (cervical or trochanteric), surgical procedure type (arthroplasty or internal fixation) and family history of fragility fractures were obtained. The included patents also were divided into two groups: a hip fracture group and a concomitant fracture of the hip and upper limb fracture group [11]. In addition, total hip bone mineral density (BMD) of the proximal femur was measured using DXA (Hologic QDR2000/QDR4500).…”

“…Li et al [11] reported that the rate of lose bone starting in midlife was ranged from 0.3% to 0.5% per year. The gut microbiota can affect bone density, bone remodeling and bone health [12][13].…”

Antivirulence activities of retinoic acids against Staphylococcus aureus

“…All- trans -retinoic acid is the most abundant retinoic acid in nature, and its isomers, which include 9- cis -retinoic acid and 13- cis -retinoic acid, are present at markedly lower levels ( Rühl et al, 2018 ). For example, the serum level of 13- cis -retinoic acid was the rage of 1.2–5.39 ng/mL in human ( Li et al, 2019 ; Yang et al, 2020 ). The usage of 13- cis -retinoic acid was approved by the FDA in 1982 for the treatment of severe acne and has been shown to influence cellular differentiation, cell-cycle progression, cell survival, and apoptosis ( Layton, 2009 ).…”

Recommendations for nutritional supplements for dry eye disease: current advances

“…Furthermore, excessive Vitamin A intake has been linked to teratogenic effects and an increased risk of birth defects when consumed at high levels (over 10,000 IU/d) during pregnancy ( Hunt, 1996 ). It can also negatively impact bone quality and increase fracture risks, such as retinoic acid can inhibit osteoblast activity, stimulate osteoclast formation, induce bone resorption, and negatively impact bone quality ( Li et al, 2019 ). A single or short-term dose of approximately 50,000 IU can provoke toxic conditions such as vomiting, increased cerebrospinal fluid pressure, blurred vision, and impaired muscle coordination ( Bendich and Langseth, 1989 ).…”