Circulating small dense LDL, endothelial injuring factors and fibronectin in healthy postmenopausal women

Muzzio, María Luz; Berg, Gabriela; Zago, Valeria; Basilio, Francisco; Sanguinetti, Silvia; López, Graciela; Brites, Fernando; Wikinski, Regina; Schreier, Laura

doi:10.1016/j.cca.2007.03.004

Cited by 21 publications

(16 citation statements)

References 36 publications

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“…Other studies found increases of CRP in those taking OC (Hung et al, 2008) with N > 4,000. With respect to menopause, post-menopausal women have shown higher levels of CRP (Muzzio et al, 2007) but other interleukins have not shown a difference (Yasui et al, 2008). Finally, CRP increases with oral, but not transdermal HRT (Eilertsen et al, 2005; Hung et al, 2008; Lacut et al, 2003; Zegura et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

O’Connor

Bower

Cho

et al. 2009

Brain, Behavior, and Immunity

442

401

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Behavioral scientists have increasingly included inflammatory biology as mechanisms in their investigation of psychosocial dynamics on the pathobiology of disease. However, a lack of standardization of inclusion and exclusion criteria and assessment of relevant control variables impacts the interpretation of these studies. The present paper reviews and discusses human biobehavioral factors that can affect the measurement of circulating markers of inflammation. Keywords relevant to inflammatory biology and biobehavioral factors were searched through PubMed. Age, sex, and hormonal status, socioeconomic status, ethnicity and race, body mass index, exercise, diet, caffeine, smoking, alcohol, sleep disruption, antidepressants, aspirin, and medications for cardiovascular disease are all reviewed. A tiered set of recommendations as to whether each variable should be assessed, controlled for, or used as an exclusion criteria is provided. These recommendations provide a framework for observational and intervention studies investigating linkages between psychosocial and behavioral factors and inflammation.

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Section: Resultsmentioning

confidence: 99%

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

O’Connor

Bower

Cho

et al. 2009

Brain, Behavior, and Immunity

442

401

View full text Add to dashboard Cite

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“…4,12 There are few reports about MMP activities in apparently healthy PMW, considered an atherosclerosis preclinical step.…”

Section: Discussionmentioning

confidence: 99%

Increased MMP-2 in healthy postmenopausal women

et al. 2011

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“…The association between visceral adipose tissue accumulation and deteriorated metabolic profile may be explained in part by high lipolytic action of visceral adipose tissue, leading to an increased flux of FFA in portal circulation to liver that increases intracellular availability of TG and stimulates the assembly and secretion of very lowdensity lipoprotein (VLDL) particles. Moreover, in postmenopausal women (PMW), an adverse lipoprotein pattern has been described, even though HDL-C levels tend to be maintained or slightly decreased [16,52]. In turn, hepatic lipase is a key enzyme involved in the hydrolysis of TG and phospholipids contained in low-density lipoprotein (LDL) and HDL particles, and, in cooperation with cholesteryl ester transfer protein (CETP), it also contributes to lipoprotein remodeling.…”

Section: Dyslipidemiamentioning

confidence: 99%

“…Moreover, the higher abdominal fat accumulation measured as waist circumference is the higher LDL oxidability. Therefore, women with high degree of insulin resistance would present an increase in small dense LDL proportion and LDL susceptibility to oxidation [52].…”

Section: Dyslipidemiamentioning

confidence: 99%

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Abdominal Obesity and Metabolic Alterations in the Menopausal Transition

Berg

Mesch

Siseles

2012

Curr Obstet Gynecol Rep

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The prevalence of overweight and obesity is strikingly increasing worldwide. Obesity is a major risk factor for non-insulin-dependent diabetes mellitus, cardiovascular diseases, and cancer, and is also associated with various psychosocial consequences. Menopausal transition is associated with unfavorable changes in body composition and abdominal fat deposition, which is accompanied by an increment of insulin resistance/hyperinsulinemia, a decrease in sex hormone-binding globulin levels and, consequently, an increase in free testosterone and greater androgenicity. Central body fat also correlates with deleterious changes in adipokines and inflammation markers like leptin, C-reactive protein, and adiponectin. In addition, the greater deposition of visceral fat in the menopausal transition contributes to the development of an atherogenic lipoprotein profile, which includes high triglyceride and low high-density lipoprotein (HDL) cholesterol concentrations, as well as an increment of small dense low-density lipoprotein (LDL) subfraction, intermediate density lipoproteins (IDL), apolipoprotein (apo) B/apo A-I ratio and lipoprotein(a).

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Circulating small dense LDL, endothelial injuring factors and fibronectin in healthy postmenopausal women

Cited by 21 publications

References 36 publications

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers

Increased MMP-2 in healthy postmenopausal women

Abdominal Obesity and Metabolic Alterations in the Menopausal Transition

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