2018
DOI: 10.1016/j.urolonc.2018.03.010
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Circulating syndecan-1 is associated with chemotherapy-resistance in castration-resistant prostate cancer

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Cited by 25 publications
(16 citation statements)
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References 31 publications
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“…Studies in multiple myeloma and breast and colon cancer detected specific proteases, including MMP-7, which is synthetized by the tumor cells, and is able to proteolytically remove the ectodomain of SDC1 [ 21 ]. In accordance, we previously found in two independent patient cohorts of bladder and prostate cancer that high soluble serum SDC1 levels are directly associated with elevated MMP-7 serum levels [ 14 , 17 ], which suggests MMP-7 as a major protease for SDC1 shedding. In the present study, we also detected a positive correlation between serum SDC1 and previously measured MMP-7 levels in BC, which further confirmed the role of MMP-7 in SDC1 shedding.…”
Section: Discussionsupporting
confidence: 89%
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“…Studies in multiple myeloma and breast and colon cancer detected specific proteases, including MMP-7, which is synthetized by the tumor cells, and is able to proteolytically remove the ectodomain of SDC1 [ 21 ]. In accordance, we previously found in two independent patient cohorts of bladder and prostate cancer that high soluble serum SDC1 levels are directly associated with elevated MMP-7 serum levels [ 14 , 17 ], which suggests MMP-7 as a major protease for SDC1 shedding. In the present study, we also detected a positive correlation between serum SDC1 and previously measured MMP-7 levels in BC, which further confirmed the role of MMP-7 in SDC1 shedding.…”
Section: Discussionsupporting
confidence: 89%
“…Further studies reported that SDC1 shedding is enhanced as a response to chemotherapy and shed SDC1 was found to be associated with chemotherapy resistance in colorectal cancer [ 16 ]. Similarly, we demonstrated high circulating pre-treatment SDC1 levels to be independently associated with poor response to docetaxel chemotherapy in patients with castration-resistant prostate cancer [ 17 ]. Our present analyses revealed for the first time an independent association between high baseline serum SDC1 concentrations and shorter OS in platinum-treated BC patients.…”
Section: Discussionmentioning
confidence: 99%
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“…To be more specific, PGs conferred resistance to tumor therapy by activating key signals such as activation of EGFR-AKT signaling by versican, inducing breast cancer self-renewal [ 256 ] and chemotherapy resistance [ 49 ], activating NF-κB signaling by biglycan to promote resistance to chemotherapy of colon cancer [ 43 ] and activating the EGFR pathway by syndecan-1 to lead to chemoresistance in colon cancer [ 257 ]. Circulating syndecan-1 contributed to chemotherapy resistance in prostate cancer [ 114 ]. For a more detailed presentation about the targeting of these molecules and the corresponding curative effect, the reader can read the recent comprehensive work presented in Reference [ 258 ].…”
Section: Clinical Featuresmentioning
confidence: 99%
“…However, in different types of cancers, syndecan-1 and syndecan-4 may present the opposite effect, promoting the tumor progression [ 64 , 65 ]. In addition, it has already been demonstrated that the shed of syndecan-1 is associated with chemotherapy resistance in castration-resistant prostate cancer [ 66 ]. These data evidence that the function of cell surface HSPGs can be altered by extracellular ectodomain shedding by proteases, converting them into soluble paracrine effector molecules.…”
Section: Heparan Sulfate Proteoglycansmentioning
confidence: 99%