Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer

Berg, Janna; Halvorsen, Ann Rita; Bengtson, May‐Bente; Lindberg, Morten; Halvorsen, Bente; Aukrust, Pål; Helland, Åslaug; Ueland, Thor

doi:10.3389/fimmu.2022.875152

Cited by 3 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies have shown the TEX process is dynamic, with a phenotypic and functional continuum of intermediate states, indicating a developmental hierarchy ( Zhang et al, 2022 ). Further researches showed that individual patients displayed different levels of T cell exhaustion ( Kim et al, 2021 ) and the presence of T cell activation or exhaustion biomarkers such as sTIM-3, CD25 in patients is evidence of this, these markers are associated with a poor outcome ( Berg et al, 2022 ). In a pan-cancer analysis, Zhang et al obtained TEX-related genes through machine learning to classify tumors in different things TEX for clinical decision-making ( Zhang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment

Ma²,

Chen³

2023

Front. Pharmacol.

View full text Add to dashboard Cite

Background: T cell exhaustion (TEX) is an important immune escape mechanism, and an in-depth understanding of it can help improve cancer immunotherapy. However, the prognostic role of TEX in malignant lung adenocarcinoma (LUAD) remains unclear.Methods: Through TCGA and GEO datasets, we enrolled a total of 498 LUAD patients. The patients in TCGA-LUAD were unsupervised clustered into four clusters according to TEX signaling pathway. WGCNA analysis, survival random forest analysis and lasso regression analysis were used to select five differentially expressed genes among different clusters to construct a TEX risk model. The risk model was subsequently validated with GEO31210. By analyzing signaling pathways, immune cells and immune checkpoints using GSEA, GSVA and Cibersortx, the relationship between TEX risk score and these variables was evaluated. In addition, we further analyzed the expression of CCL20 at the level of single-cell RNA-seq and verified it in cell experiments.Results: According to TEX signaling pathway, people with better prognosis can be distinguished. The risk model constructed by CD109, CCL20, DKK1, TNS4, and TRIM29 genes could further accurately identify the population with poor prognosis. Subsequently, it was found that dendritic cells, CD44 and risk score were closely related. The final single-cell sequencing suggested that CCL2O is a potential therapeutic target of TEX, and the interaction between TEX and CD8 + T is closely related.Conclusion: The classification of T cell depletion plays a crucial role in the clinical decision-making of lung adenocarcinoma and needs to be further deepened.

show abstract

Section: Introductionmentioning

confidence: 99%

A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment

Ma²,

Chen³

2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

Mechanisms of radiation‐induced tissue damage and response

Zhou,

Zhu,

Liu

et al. 2024

MedComm

View full text Add to dashboard Cite

Radiation‐induced tissue injury (RITI) is the most common complication in clinical tumor radiotherapy. Due to the heterogeneity in the response of different tissues to radiation (IR), radiotherapy will cause different types and degrees of RITI, which greatly limits the clinical application of radiotherapy. Efforts are continuously ongoing to elucidate the molecular mechanism of RITI and develop corresponding prevention and treatment drugs for RITI. Single‐cell sequencing (Sc‐seq) has emerged as a powerful tool in uncovering the molecular mechanisms of RITI and for identifying potential prevention targets by enhancing our understanding of the complex intercellular relationships, facilitating the identification of novel cell phenotypes, and allowing for the assessment of cell heterogeneity and spatiotemporal developmental trajectories. Based on a comprehensive review of the molecular mechanisms of RITI, we analyzed the molecular mechanisms and regulatory networks of different types of RITI in combination with Sc‐seq and summarized the targeted intervention pathways and therapeutic drugs for RITI. Deciphering the diverse mechanisms underlying RITI can shed light on its pathogenesis and unveil new therapeutic avenues to potentially facilitate the repair or regeneration of currently irreversible RITI. Furthermore, we discuss how personalized therapeutic strategies based on Sc‐seq offer clinical promise in mitigating RITI.

show abstract

Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4

Pei,

Cheng,

Liu

et al. 2023

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer

Cited by 3 publications

References 73 publications

A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment

A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment

Mechanisms of radiation‐induced tissue damage and response

Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4

Contact Info

Product

Resources

About