Circulating Tissue Thromboplastin during Hip Surgery

Abstract

An immunoradiometric assay for tissue thromboplastin has been established. Blood levels in 6 patients undergoing total hip replacement have been determined. In 3 patients, high levels of circulating apoprotein III were found at various stages of the operation, showing a release of tissue thromboplastin chiefly during impaction of the prosthesis into the femoral bone. The other 3 patients had low or undetectable levels.

The Effect of Gram-Negative Phospholipase C (Phosphatidylcholine Hydrolyzing) on Blood Coagulation

“…After surgery and trauma thromboplastin may be responsible for thromboembolic episodes (10,11). Studies in this direction are carried out with PLC (B. cereus) by Hetland et al (13,14), Carlsen et al (5) as a therapeutic or prophylactic agent in thrombosis and other form of intravascular coagulation.…”

Thromboembolism and thromboprophylaxis in high risk surgery: facts and assumptions - a topic for emotions?

“…Trauma to the large bones causes extravasation of bone marrow cells [17]. These cells have a high content of tissue factor (TF) [18] and high blood concentrations have been measured by Giercksky and his coworkers [19]. This triggers activation of coagulation locally in veins draining the operative area [20].…”

Fettemboli er en utdatert diagnose

“…Her vil vi fremheve traumets generering av vevsfaktor og mekanismestudier av respiratorisk stress ved bruk av fettemulsjoner (10,11), embolisering fra benmargen ved leddprotesekirurgi og bentraumer (12), systemisk mikroembolisering (3), ikke påvisbar effekt av kortikosteroider (13), betydningen av trykkstigningen i lårbenet under innstøpningen av den sementerte femurprotesen for de perioperative dødsfallene (6,12,14) og nylig påvist senket postoperativ mortalitet ved bruk av heparin før proteseinnsettingen hos lårhalsbruddpasienter (9).…”