Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance

Pereira-Veiga, Thais; Schneegans, Svenja; Pantel, Klaus; Wikman, Harriet

doi:10.1016/j.celrep.2022.111298

Cited by 78 publications

(52 citation statements)

References 154 publications

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“… 29 , 30 In addition to being a major blood component, numerous studies showed that platelets have numerous interactions with HCC and the tumor microenvironment, which not only promote the growth of HCC but also cause the shedding and metastasis of HCC cells. 7 , 9 , 10 , 20 The anti-platelet therapy can inhibit related tumor pathways, attenuate hepatic inflammatory response, delay tumor progression, and improve the prognosis of HCC patients. 31 , 32 Moreover, platelets are the targets of signaling molecules for the treatment of HCC.…”

Section: Discussionmentioning

confidence: 99%

“… 16 , 18 The immune cells cannot recognize CTCs, which leads to an increase in their survival rate. 17 , 19 , 20 Furthermore, the platelets stimulate the shedding and metastasis of cancer cells by releasing a large number of cytokines and interact with the tumor microenvironment by enhancing inflammatory response and forming new blood vessels. 21 , 22 Therefore, the protective effects of platelets on the survival of CTCs should be considered even in the presence of a small number of CTCs.…”

Section: Introductionmentioning

confidence: 99%

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High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells

Zhan¹,

Huang²,

Huang³

et al. 2023

JHC

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Purpose Recent studies indicated the vital role of platelet in enhancing the survival of circulating tumor cells (CTCs) in the blood, thereby stimulating the metastasis of tumors. CTCs have been considered an indicator of early tumor recurrence. Therefore, this study evaluated the prognostic potential of platelet count in predicting the early recurrence of hepatocellular carcinoma (HCC) in the presence of CTCs. Patients and Methods 127 patients, whose preoperative CTCs were detected, were enrolled in this study. Univariate analysis was performed to identify the significant association of factors with the early recurrence of HCC, followed by multivariate analysis to determine the independent prognostic indicators. The prediction potential was evaluated using receiver operating characteristic (ROC) curves. Results A total of 81 (63.7%) patients showed early HCC recurrence. The platelet count ≥225×10 9 /L (hazard ratio, HR: 1.679, P = 0.041), CTCs >5/5 mL (HR: 2.467, P = 0.001), and presence of microvascular invasion (MVI) (HR: 2.580, P = 0.002) were independent factors correlated with the early recurrence of HCC in multivariate analysis. The prognostic potential of the combined CTCs-platelet count (0.738) was better than that of CTCs (0.703) and platelet (0.604) alone. The subgroup analysis, excluding 23 patients with pathological cirrhosis and splenomegaly, showed that the platelet count ≥225×10 9 /L and CTCs >5/5 mL were also independent factors of early HCC recurrence. The prediction potential of the combined CTCs-platelet count was 0.753, which was better than that of the whole cohort. Kaplan–Meier survival curve analysis indicated that the HCC patients with high platelet or CTCs had the worse recurrence-free survival (RFS). Conclusion The high platelet count was an independent factor of early HCC recurrence in the presence of CTCs. The combination of preoperative CTCs and platelet count could effectively predict the early recurrence of HCC. The subgroup analysis also showed similar results.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells

Zhan¹,

Huang²,

Huang³

et al. 2023

JHC

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“…Platelets may be employable as an all-in-one biosource to broadly search molecular traces of cancer and provide a strong indication on tumor type and molecular subclass ( Best et al, 2015 ). Their involvement in metastasis generation has been recently studied: TEPs seem to contribute to the survival of CTCs by protecting them from immune attacks and shear stress, promoting CTC intravenous extravasation ( Liu et al, 2021b ; Pereira-Veiga et al, 2022 ).…”

Section: Liquid Biopsy Elementsmentioning

confidence: 99%

Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review

et al. 2023

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In the last years, liquid biopsy gained increasing clinical relevance for detecting and monitoring several cancer types, being minimally invasive, highly informative and replicable over time. This revolutionary approach can be complementary and may, in the future, replace tissue biopsy, which is still considered the gold standard for cancer diagnosis. “Classical” tissue biopsy is invasive, often cannot provide sufficient bioptic material for advanced screening, and can provide isolated information about disease evolution and heterogeneity. Recent literature highlighted how liquid biopsy is informative of proteomic, genomic, epigenetic, and metabolic alterations. These biomarkers can be detected and investigated using single-omic and, recently, in combination through multi-omic approaches. This review will provide an overview of the most suitable techniques to thoroughly characterize tumor biomarkers and their potential clinical applications, highlighting the importance of an integrated multi-omic, multi-analyte approach. Personalized medical investigations will soon allow patients to receive predictable prognostic evaluations, early disease diagnosis, and subsequent ad hoc treatments.

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“…Firstly, the tumor cells detach from the primary site and subsequently destroy the intercellular matrix and stimulate the formation of capillaries [ 27 ]. Afterwards, the primary tumor cells break through the basement membrane and enter the capillaries and follow the blood circulation to all parts of the body [ 28 , 29 ]. The surviving tumor cells stay in the right conditions, cross the capillary walls, and leave the blood circulation [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Coding RNAs Derived from Extracellular Vesicles Promote Pre-Metastatic Niche Formation and Tumor Distant Metastasis

Jin

Zhang

et al. 2023

Cancers

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Metastasis is a critical stage of tumor progression, a crucial challenge of clinical therapy, and a major cause of tumor patient death. Numerous studies have confirmed that distant tumor metastasis is dependent on the formation of pre-metastatic niche (PMN). Recent studies have shown that extracellular vesicles (EVs) play an important role in PMN formation. The non-coding RNAs (ncRNAs) derived from EVs mediate PMN formation and tumor-distant metastasis by promoting an inflammatory environment, inhibiting anti-tumor immune response, inducing angiogenesis and permeability, and by microenvironmental reprogramming. Given the stability and high abundance of ncRNAs carried by EVs in body fluids, they have great potential for application in tumor diagnosis as well as targeted interventions. This review focuses on the mechanism of ncRNAs derived from EVs promoting tumor PMN formation and distant metastasis to provide a theoretical reference for strategies to control tumor metastasis.

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Circulating tumor cell-blood cell crosstalk: Biology and clinical relevance

Cited by 78 publications

References 154 publications

High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells

High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells

Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review

Non-Coding RNAs Derived from Extracellular Vesicles Promote Pre-Metastatic Niche Formation and Tumor Distant Metastasis

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