Circulating tumour cells in gastrointestinal cancers: food for thought?

Asawa, Simran; Nüesch, Manuel; Gvozdenovic, Ana; Aceto, Nicola

doi:10.1038/s41416-023-02228-8

Cited by 10 publications

(3 citation statements)

References 137 publications

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“…About thirty years ago, pioneering studies used different murine models to elucidate the reasons for this organ-specific metastatic process [2]. More recently, new strategies with simple biomaterial-or microfluidics-based co-cultures have tried to summarize this complex microenvironment to better understand the interactions between cancer cells and the stroma at the metastatic site [3].…”

Section: Introductionmentioning

confidence: 99%

“…As the main contributor is the portal vein [6], the hepatic sinusoids are directly exposed to CTCs emerging from primary malignant tumors developing in the gastrointestinal tract. The fenestrated vasculature that characterizes the liver [5] also explains why CTCs easily exit the vessels and preferentially colonize this organ [3]. The different steps of this colonization have been remarkably deciphered and illustrated, emphasizing the role of complex interactions between tumor cells and a great diversity of highly specialized resident cells, among which hepatocytes play an important role [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Pouliquen

2024

Explor Dig Dis

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The liver, characterized by a unique metabolic and immunosuppressive environment, is also the organ to which invasive malignant cells of many different cancer types most frequently metastasize. The reasons for this organ-specific metastatic process have been investigated for decades. This review first provides an overview of recent breakthroughs in this field, introducing intercellular communication between circulating tumor cells and the heterogeneous cell populations of the liver, and modifications to the extracellular matrix (ECM). Subsequently, to improve the understanding of the molecular mechanisms involved in the metastasis of colorectal cancer to the liver, the second leading cause of cancer-related mortality, the recent literature on this question was analyzed. Among the various parameters involved, the mechanisms behind the activation of hepatic stellate cells, proteins inducing ECM remodeling, specific genomic features of liver metastases, metabolic rewiring, and characteristics of stromal-enriched microenvironments were discussed. To provide more insights into the molecular determinants of liver metastatic colonization, important findings reported on a set of mitochondrial proteins were addressed, the relative abundance of which changed in the liver during the progression stage of an aggressive experimental model of peritoneal malignant mesothelioma in immunocompetent rats. Based on previous studies cross-comparing the liver proteomes from curcumin-treated tumor-bearing rats/untreated tumor-bearing rats/normal rats, data from the literature were reviewed for 25 mitochondrial proteins of interest. Their role in lipid metabolism, heme biosynthesis, the electron transport chain, small molecule transport, mitochondrial dynamics, the tricarboxylic acid cycle, and protection against oxidative stress were analyzed in the context of both cancer and non-malignant liver diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Pouliquen

2024

Explor Dig Dis

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“…Gastrointestinal (GI) cancer is a prevalent and highly malignant tumor in clinical practice [1]. Stomach cancer, in particular, ranks third in terms of mortality due to its low survival rate, with 782,685 deaths reported in 2018 [2].…”

Section: Introductionmentioning

confidence: 99%

Stereo Visual Servoing Control of a Soft Endoscope for Upper Gastrointestinal Endoscopic Submucosal Dissection

Chen,

Wang,

Zhao

et al. 2024

Micromachines

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Quickly and accurately completing endoscopic submucosal dissection (ESD) operations within narrow lumens is currently challenging because of the environment’s high flexibility, invisible collision, and natural tissue motion. This paper proposes a novel stereo visual servoing control for a dual-segment robotic endoscope (DSRE) for ESD surgery. Departing from conventional monocular-based methods, our DSRE leverages stereoscopic imaging to rapidly extract precise depth data, enabling quicker controller convergence and enhanced surgical accuracy. The system’s dual-segment configuration enables agile maneuverability around lesions, while its compliant structure ensures adaptability within the surgical environment. The implemented stereo visual servo controller uses image features for real-time feedback and dynamically updates gain coefficients, facilitating rapid convergence to the target. In visual servoing experiments, the controller demonstrated strong performance across various tasks. Even when subjected to unknown external forces, the controller maintained robust performance in target tracking. The feasibility and effectiveness of the DSRE were further verified through ex vivo experiments. We posit that this novel system holds significant potential for clinical application in ESD surgeries.

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Isolation of circulating tumor cells: recent progress and future perspectives

Guo,

Xia

2024

Med-X

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Circulating tumor cells (CTCs) are cancer cells that shed from the primary tumor and enter into body fluids of the patient, where they travel to distant sites and ultimately form metastasis. Understanding the biology of CTCs, in particular at the critical stages of their itinerary, holds promises for better cancer cure. Since the beginning of this century, liquid biopsy has steadily grown to be a keen area of research due to its non-invasive features. As one of the most promising tumor biomarkers, CTCs have shown great potential in cancer diagnosis, prognosis, treatment response monitoring, and the exploration of biological mechanisms. Although various types of isolation and detection technologies emerge constantly, the rarity and heterogeneity of CTCs still pose huge challenges for these methods and make them inefficient. In addition, the clinical practice of different technologies still lacks reasonable and uniform standards. In this review, we provide a detailed overview of the isolation and enrichment strategies of CTCs, as well as their advantages and limitations. By summarizing the current status and suggesting future areas of CTCs research, we hope to continue the concerted effort for pushing forward the clinical application of CTCs, which may represent a paradigm shift for cancer theranostics in the future. Graphical Abstract

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Circulating tumour cells in gastrointestinal cancers: food for thought?

Cited by 10 publications

References 137 publications

Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Liver metastatic colonization by invasive cancer cells: a review of potential biomarkers with mitochondrial involvement

Stereo Visual Servoing Control of a Soft Endoscope for Upper Gastrointestinal Endoscopic Submucosal Dissection

Isolation of circulating tumor cells: recent progress and future perspectives

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