Circulation autoantibodies against C-terminus of NuMA in patients with Behçet’s disease

Hussain, Muhammad; Chen, P; Tian, Yaping; Du, Hong

doi:10.5114/ceji.2020.94710

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Autoantibodies were observed in patients with BD and reacted with an endothelial cell antigen, α-enolase (a positive rate of 38% by an ELISA) ( 85 ), a ubiquitously expressed membrane protein, prohibitin (28% by an ELISA) ( 86 ), α-tropomyosin (22% by an ELISA) ( 87 ), the nuclear mitotic apparatus protein (NuMA; 28% by an ELISA) ( 88 ), a riboflavin-containing flavoprotein (41% by an ELISA) ( 89 ), a membrane protein annexin A2 (34% by an ELISA) ( 90 ), a microtubule-related protein, kinectin (23% by an immunoprecipitation assay) ( 91 ), and an actin-binding protein, cofilin-1 (13% by western blotting; Figure 2A ) ( 92 ). Thus, BD demonstrates a mixed pattern of autoinflammatory and autoimmune diseases within the spectrum ( 14 ).…”

Section: Behçet Diseasementioning

confidence: 99%

Innate immune responses in Behçet disease and relapsing polychondritis

et al. 2023

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Behçet disease (BD) and relapsing polychondritis (RP) are chronic multisystem disorders characterized by recurrent flare-ups of tissue inflammation. Major clinical manifestations of BD are oral aphthae, genital aphthous ulcers, skin lesions, arthritis, and uveitis. Patients with BD may develop rare but serious neural, intestinal, and vascular complications, with high relapse rates. Meanwhile, RP is characterized by the inflammation of the cartilaginous tissues of the ears, nose, peripheral joints, and tracheobronchial tree. Additionally, it affects the proteoglycan-rich structures in the eyes, inner ear, heart, blood vessels, and kidneys. The mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome is a common characteristic of BD and RP. The immunopathology of these two diseases may be closely related. It is established that the genetic predisposition to BD is related to the human leukocyte antigen (HLA)-B51 gene. Skin histopathology demonstrates the overactivation of innate immunity, such as neutrophilic dermatitis/panniculitis, in patients with BD. Monocytes and neutrophils frequently infiltrate cartilaginous tissues of patients with RP. Somatic mutations in UBA1, which encodes a ubiquitylation-related enzyme, cause vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome (VEXAS) with severe systemic inflammation and activation of myeloid cells. VEXAS prompts auricular and/or nasal chondritis, with neutrophilic infiltration around the cartilage in 52–60% of patients. Thus, innate immune cells may play an important role in the initiation of inflammatory processes underlying both diseases. This review summarizes the recent advances in our understanding of the innate cell-mediated immunopathology of BD and RP, with a focus on the common and distinct features of these mechanisms.

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Section: Behçet Diseasementioning

confidence: 99%

Innate immune responses in Behçet disease and relapsing polychondritis

et al. 2023

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“…The tissue sections of the ulcers isolated from BD patients revealed that serum IgA autoantibodies colocalized with monoclonal antibodies against hnRNP A2/B1 (Cho, Zheng, Cho, et al, 2013). In addition, hnRNP C1/C2 and hnRNP A1 were also identified as potential autoantigens in BD and the positivity of hnRNP A1 autoantibodies was associated with the deep vein thrombosis (Chen et al, 2016; Hussain et al, 2018).…”

Section: Hnrnps Are Autoantigens In Autoimmune Diseases and Associate...mentioning

confidence: 99%

Undervalued and novel roles of heterogeneous nuclear ribonucleoproteins in autoimmune diseases: Resurgence as potential biomarkers and targets

Chen

Luo

et al. 2023

WIREs RNA

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Autoimmune diseases are mainly characterized by the abnormal autoreactivity due to the loss of tolerance to specific autoantigens, though multiple pathways associated with the homeostasis of immune responses are involved in initiating or aggravating the conditions. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a major category of RNA‐binding proteins ubiquitously expressed in a multitude of cells and have attracted great attentions especially with their distinctive roles in nucleic acid metabolisms and the pathogenesis in diseases like neurodegenerative disorders and cancers. Nevertheless, the interplay between hnRNPs and autoimmune disorders has not been fully elucidated. Virtually various family members of hnRNPs are increasingly identified as immune players and are pertinent to all kinds of immune‐related processes including immune system development and innate or adaptive immune responses. Specifically, hnRNPs have been extensively recognized as autoantigens within and even beyond a myriad of autoimmune diseases, yet their diagnostic and prognostic values are seemingly underestimated. Molecular mimicry, epitope spreading and bystander activation may represent major putative mechanisms underlying the presence of autoantibodies to hnRNPs. Besides, hnRNPs play critical parts in regulating linchpin genes expressions that control genetic susceptibility, disease‐linked functional pathways, or immune responses by interacting with other components particularly like microRNAs and long non‐coding RNAs, thereby contributing to inflammation and autoimmunity as well as specific disease phenotypes. Therefore, comprehensive unraveling of the roles of hnRNPs is conducive to establishing potential biomarkers and developing better intervention strategies by targeting these hnRNPs in the corresponding disorders.This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications

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Finding the Needle in the Haystack: Serological and Urinary Biomarkers in Behçet’s Disease: A Systematic Review

Arbrile

Radin

Medica

et al. 2023

IJMS

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Urinary and serological markers play an essential role in the diagnostic process of autoimmune diseases. However, to date, specific and reliable biomarkers for diagnosing Behçet’s disease (BD) are still lacking, negatively affecting the management of these patients. To analyze the currently available literature on serological and urinary BD biomarkers investigated in the last 25 years, we performed a systematic literature review using the Population, Intervention, Comparison, and Outcomes (PICO) strategy. One hundred eleven studies met the eligibility criteria (6301 BD patients,5163 controls). Most of them were retrospective, while five (5%) were prospective. One hundred ten studies (99%) investigated serological biomarkers and only two (2%) focused on urinary biomarkers. One hundred three studies (93%) explored the diagnostic potential of the biomolecules, whereas sixty-two (56%) tested their effect on disease activity monitoring. Most articles reported an increase in inflammatory markers and pro-oxidant molecules, with a decrease in antioxidants. Promising results have been shown by the omics sciences, offering a more holistic approach. Despite the vast number of investigated markers, existing evidence indicates a persistent gap in BD diagnostic/prognostic indices. While new steps have been taken in the direction of pathogenesis and disease monitoring, international efforts for the search of a diagnostic marker for BD are still needed.

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Circulation autoantibodies against C-terminus of NuMA in patients with Behçet’s disease

Cited by 3 publications

References 31 publications

Innate immune responses in Behçet disease and relapsing polychondritis

Innate immune responses in Behçet disease and relapsing polychondritis

Undervalued and novel roles of heterogeneous nuclear ribonucleoproteins in autoimmune diseases: Resurgence as potential biomarkers and targets

Finding the Needle in the Haystack: Serological and Urinary Biomarkers in Behçet’s Disease: A Systematic Review

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