Circulation of human coronaviruses OC43 and 229E in Córdoba, Argentina

Ottogalli, María Emilia; Rodríguez, Pamela; Frutos, María Celia; Moreno, Laura; Ghietto, Lucía María; Cuffini, Cecilia; Cámara, Jorge; Adamo, María Pilar; Valinotto, Laura; Cámara, Alicia

doi:10.1007/s00705-020-04914-x

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…We detected a high prevalence of HBoV1 (24 %) in our series, confirming a distribution concentrated in the first year of life. Unlike other respiratory viruses such as FLU, RSV and seasonal coronaviruses, which commonly peak during the months of autumn and winter [30, 31]⁠, most HBoV1+ cases occurred during the winter and spring, while the annual variations over the years spanning this study are probably due to the intrinsic circulation pattern of the virus [32–34]⁠.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and clinical significance of Human bocavirus 1 in children hospitalized for lower acute respiratory infection: molecular detection in respiratory secretions and serum

Salbetti

Boggio

Abbiatti

et al. 2022

Journal of Medical Microbiology

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Introduction. Human bocavirus 1 (HBoV1) infection occurs with viral genome presence in respiratory secretions (RS) and serum, and therefore both samples can be used for diagnosis. Gap statement. The diagnostic sensitivity of HBoV1 DNA detection in serum and the duration of DNAaemia in severe clinical cases have not been elucidated. Aim. To determine HBoV1 DNA in serum and RS of paediatric patients hospitalized for lower acute respiratory infection (LARI) and to analyse the clinical–epidemiological features of positive cases. Methodology. This was a prospective, transverse study. Physicians selected the clinical situations and obtained paired clinical samples (RS and serum) that were tested by PCR/qPCR for HBoV1. Positive cases were analysed considering time of specimen collection, co-detection, clinical manifestations and viral load; statistical significant level was set at α=0.05. Results. HBoV1 was detected in 98 of 402 cases included (24 %); 18/98 (18 %) patients had the virus detectable in serum and 91/98 (93 %) in RS (P<0.001). Positivity rates were not significantly different in patients with RS and serum collected within or beyond 24 h of admission. Single HBoV1 infection was identified in 39/98 patients (40 %), three patients had HBoV1 in both clinical samples (3/39, 8 %) and 32 (32/39, 82 %) only in RS, 22 of them (69 %) with both clinical samples within 24 h of admission. Cough (P=0.001) and rhinitis (P=0.003) were significantly frequent among them and most patients were diagnosed with bronchiolitis (22/39, 56 %) and pneumonia (9/39, 23 %), which was more frequent compared to cases with co-infection (P=0.04). No significant differences were identified among patients with high, medium or low viral load of HBoV1 regarding rate of positivity in both clinical samples, the time of collection of RS and serum, co-detection, first episode of LARI, clinical manifestations, comorbidity or requirement for assisted ventilation. Intensive care unit (ICU) patients had a significantly higher frequency of detection (P<0.001) and co-detection (P=0.001) compared to patients on standard care. Conclusions. HBoV1 is prevalent among infant patients hospitalized for LARI and including it in the standard testing can add to the aetiological diagnosis in these cases, especially for patients admitted to the ICU. HBoV1 detection in serum did not contribute significantly to the diagnosis as compared to detection in respiratory secretions.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and clinical significance of Human bocavirus 1 in children hospitalized for lower acute respiratory infection: molecular detection in respiratory secretions and serum

Salbetti

Boggio

Abbiatti

et al. 2022

Journal of Medical Microbiology

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“…Children of all ages, especially infants under one year old, are susceptible. 5 This study showed that children infected with human coronavirus were primarily under three years old, accounting for 82.76%, and 53.48% of them were under one year old. This result is consistent with previous studies.…”

Section: Discussionmentioning

confidence: 75%

Clinical Study of Human Coronavirus NL63, OC43, 229E, HKU1 Infentions in Hospitalized Children from 2015 to 2020

Wen¹,

Sun²,

Zhao³

et al. 2022

IDR

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Objective This study aims to analyze the clinical characteristics of hospitalized children infected with HCoV-NL63, OC43, 229E, HKU1 and provide the basis for disease diagnosis and treatment. Methods A retrospective analysis was conducted on clinical manifestations, imaging data, and treatment measures of hospitalized children with positive HCoV-NL63, OC43, 229E, HKU1 from 2015 to 2020. Results A total of 1062 children aged 33 days to 12 years were analyzed, including 879 (82.77%) between 33 days to three years. Lower respiratory tract infections were the most common in 698 children positive for HCoVs (65.72%). The incidences of runny nose, cough, pharyngeal hyperemia, and fine crackles in the mild case group (n = 894, 84.18%) were significantly higher than in the severe case group, and the differences were statistically significant ( P < 0.01). The incidences of gasp, stridor, and convulsions, the proportion of underlying diseases, such as congenital heart disease, laryngomalacia, and general developmental disorders, anemia, and abnormal liver function, and mixed infections in the severe group (n = 168, 15.82%) were significantly higher than in the mild group, and the differences were statistically significant ( P < 0.01 or P < 0.05). Imaging manifestations differed. Pleural effusion and atelectasis occurred in the severe cases. After treatment, patients fully recovered or improved and were discharged from the hospital. There were no deaths. Conclusion HCoV-NL63, OC43, 229E, HKU1 infection is most common in children under three years old, and the infection site is mainly the lower respiratory tract. The main clinical manifestations include fever, cough, and runny nose. Inspiratory three concave signs, respiratory failure, and heart failure occurred in the severe cases, with pleural effusion and atelectasis possibly occurring at the same time. Severe cases should be identified early so that they may be given comprehensive treatment in time to improve the prognosis.

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“…Usually HBoV1 peaks after influenza, RSV and seasonal coronaviruses. [93][94][95] Viral circulation, even based on molecular detection, is variable, with major outbreaks every few years. 44,49,58,96 The analysis of the circulation and dynamics of virus transmission in different epidemiological settings is crucial due to interactions among respiratory viruses, which can have significant health implications.…”

Section: Epidemiologymentioning

confidence: 99%

“…Cases tend to peak during cold months along with reports of influenza‐like illness, although HBoV1 infections can be detected year‐round. Usually HBoV1 peaks after influenza, RSV and seasonal coronaviruses 93–95 . Viral circulation, even based on molecular detection, is variable, with major outbreaks every few years 44,49,58,96 .…”

Section: Epidemiologymentioning

confidence: 99%

Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

Colazo Salbetti,

Boggio,

Moreno

et al. 2023

Reviews in Medical Virology

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Human bocaviruses were first described between 2005 and 2010, identified in respiratory and enteric tract samples of children. Screening studies have shown worldwide distribution. Based on phylogenetic analysis, they were classified into four genotypes (HBoV1‐4). From a clinical perspective, human bocavirus 1 (HBoV1) is considered the most relevant, since it can cause upper and lower acute respiratory tract infection, mainly in infants, including common cold, bronchiolitis, and pneumonia, as well as wheezing in susceptible patients. However, the specific processes leading to structural, biochemical, and functional changes resulting in the different clinical presentations have not been elucidated yet. This review surveys the interactions between the virus and target cells that can potentially explain disease‐causing mechanisms. It also summarises the clinical phenotype of cases, stressing the role of HBoV1 as an aetiological agent of lower acute respiratory infection in infants, together with laboratory tests for detection and diagnosis. By exploring the current knowledge on the epidemiology of HBoV1, insights into the complex scenario of paediatric respiratory infections are presented, as well as the potential effects that changes in the circulation can have on the dynamics of respiratory agents, spotlighting the benefits of comprehensively increase insights into incidence, interrelationships with co‐circulating agents and potential control of HBoV1.

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Circulation of human coronaviruses OC43 and 229E in Córdoba, Argentina

Cited by 4 publications

References 35 publications

Diagnosis and clinical significance of Human bocavirus 1 in children hospitalized for lower acute respiratory infection: molecular detection in respiratory secretions and serum

Diagnosis and clinical significance of Human bocavirus 1 in children hospitalized for lower acute respiratory infection: molecular detection in respiratory secretions and serum

Clinical Study of Human Coronavirus NL63, OC43, 229E, HKU1 Infentions in Hospitalized Children from 2015 to 2020

Human bocavirus respiratory infection: Tracing the path from viral replication and virus‐cell interactions to diagnostic methods

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