Circulatory Adjustments to Pregnancy in the Rabbit

Bjellin, L.; Carter, A. M.

doi:10.1095/biolreprod16.1.112

Cited by 10 publications

(7 citation statements)

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“…Both this study and that of Bjellin & Carter (1977) have shown an increase in red cell volume and a smaller increase in plasma volume in the rabbit. The study of Nuwayhid (1979) showing large increases in both red cell and plasma volume in the rabbit is also illustrated, although as discussed above, these findings may be less reliable.…”

Section: Site Of the Blood Volume Increasesupporting

confidence: 59%

“…The only other studies of blood volume in the pregnant rabbit are those of Bjellin & Carter (1977) and Nuwayhid (1979). Bjellin & Carter derived blood volume from plasma volume measured with Indocyanine green and arterial haematocrit.…”

Section: The Effect Ofpregnancy On Blood Volume In the Rabbitmentioning

confidence: 99%

“…Bjellin & Carter (1977) reported that pregnancy in the rabbit led to only a small increase in blood volume of 4 ml. kg-1, whereas Nuwayhid (1979) claimed that blood volume increased by 19 ml.…”

Section: Introductionmentioning

confidence: 99%

“…Studies of blood volume in the rabbit extend back over more than seventy years (see review by Sjostrand, 1962), but despite the frequent use of rabbits in investigations of the effects of pregnancy, there are only two previous reports describing the changes in blood volume during pregnancy in this species (Bjellin & Carter, 1977;Nuwayhid, 1979) and these present conflicting findings. Bjellin & Carter (1977) reported that pregnancy in the rabbit led to only a small increase in blood volume of 4 ml. kg-1, whereas Nuwayhid (1979) claimed that blood volume increased by 19 ml.…”

Section: Introductionmentioning

confidence: 99%

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Blood Volume in the Pregnant Rabbit

Prince

1982

Exp Physiol

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SUMMARYRed cell and plasma volumes were measured using "Cr-labelled red cells and l2"I-labelled HSA respectively, in seventeen pregnant rabbits at 28-29 days ofpregnancy, and fifteen non-pregnant rabbits weight-matched with the pregnant rabbits before mating. Red cell volume in the pregnant group (200 + 27 ml. kg-'; mean+ S.D.), was greater than in the control rabbits (180 + 20 ml. kg-1; P < 0 05); plasma volumes (390 + 4-5 and 37-3 + 4-4 ml. kg-' respectively) were not statistically different. Blood volume was derived from the sum of independently measured red cell and plasma volumes. That of the pregnant group (59 0 + 5-3 ml. kg-') was just significantly greater than that of the control rabbits (55 3 + 5 3 ml. kg-'; P < 0-05). When the volume ofdistribution of the labels was corrected, by subtracting fetal weight from maternal body weight, the red cell, plasma and blood volumes were all significantly greater in the pregnant rabbits (P < 0-02). Although the large vessel haematocrit of the pregnant group (41-6 + 4-4%) exceeded that of the non-pregnant group (38 7+2-6%; P < 005), there was no significant difference in whole body haematocrit or Fcells (the ratio of whole body to large vessel haematocrit) between the two groups of rabbits.

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Section: Site Of the Blood Volume Increasesupporting

confidence: 59%

Section: The Effect Ofpregnancy On Blood Volume In the Rabbitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Blood Volume in the Pregnant Rabbit

Prince

1982

Exp Physiol

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“…In the rabbit, total peripheral resistance falls during pregnancy by 15-25 % (Bjellin & Carter, 1977; Humphreys & Joels, 1977; Nuwayhid, 1979). Since the uterine blood flow near term is only about 7 % of cardiac output (Duncan, 1969) we have looked in other beds for changes which might contribute to this fall.…”

Section: Introductionmentioning

confidence: 99%

The response of the hind‐limb vascular bed of the rabbit to sympathetic stimulation and its modification by pregnancy.

Humphreys¹,

Joels²

1982

The Journal of Physiology

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SUMMARY1. Pressure-flow relationships in the hind limb, perfused with blood at a series of constant flows, have been compared in primigravid and virgin rabbits following section of the lumbar sympathetic chain.2. In the absence of sympathetic stimulation perfusion pressure was lower (P < 0 05) in the pregnant rabbits at all levels of flow to the leg.3. It is concluded that pregnancy leads to a reduction in the vascular resistance of the acutely sympathectomized hind limb.4. The pressure-flow curves of hind limbs from pregnant and non-pregnant rabbits in which the cutaneous circulation had been excluded by skinning the leg and ligating the ankle were also compared. Again, perfusion pressure at each flow level was lower in the limbs from the pregnant animals (P < 0 05).5. The sympathetic supply was stimulated at frequencies of 0 3, 1, 3, 7, 15 and 30 Hz. Irrespective of whether the cutaneous circulation was excluded, the pressureflow curves for the hind limbs of pregnant and non-pregnant rabbits were different at the lower frequencies. As stimulus frequency rose this difference became smaller, and at a stimulus frequency of 7-15 Hz or more there was little difference in the position of the curves in pregnant and non-pregnant rabbits.6. Examination of the pressure-flow curves suggests that when, as in these experiments, flow is held constant, the ability of sympathetic stimulation to increase the resistance to blood flow is reduced in pregnancy. However, if these pressure-flow curves are used to predict the change of flow that would occur at a constant perfusion pressure, the response to sympathetic stimulation appears to be greater in pregnancy.7. Futher analysis of the findings, based on certain assumptions, suggests that differences between the pressure-flow curves of pregnant and non-pregnant animals during sympathetic stimulation are due in the main to either a differing size of the unstimulated vascular beds or a differing compliance of their vessel walls, rather than to any intrinsic alteration in their response to sympathetic stimulation.

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