Circulatory and Metabolic Effects of Innovar??-Fentanyl-Nitrous Oxide Anesthesia for Major Abdominal Surgery in Man

Effects of Neurolept Anaesthesia (NLA) on Haemodynamics and Oxygen Consumption in the Dog with Special Reference to the Liver and Preportal Tissues

“…Artificial ventilation is also known to affect cardiovascular performance (AOYACI & PIIPER 1965), but nitrous oxide seems to have only negligible circulatory effects per se (CRAY- 1966, DOTTORI et al 1976), although it may modify the circulatory response to other anaesthetics (SMITH & CORRASCIO 1966, SMITH et al 1970, STOELTINC et al 1975. The induction dose of thiopental preceded the experimental period by at least 2 hours, after which only a few small doses were given; the last one always a t least 30 minutes before the experiment was started.…”

“…Neurolept anaesthesia (NLA), defined as the combined use of droperidol, fentanyl and nitrous oxide (HOLDERNESS et al 1963et al , MORGAN et al 1974, has become a valuable alternative to other forms of general anaesthesia in the anaesthetic management of major surgery in the poor-risk patient (CORSSEN , Fox et al 1967, DOBKIN et al 1970, JACOBSON et al 1970, MORGAN et al 1974. The main reason for this is the stability of cardiovascular function during NLA, which has been demonstrated in several studies in man (DOBKIN , ZAUDER et al 1965, DOBKIN et al 1970, TARHAN et al 1971, STOELTINC et al 1975. Other studies have shown, however, that NLA may cause moderate cardiovascular depression (MACDONALD , PRYS-ROBERTS & KELMAN 1967, BRISMAR et al 1977, SANTESSON et al 1978.…”

Haemodynamic Effects of Labetalol-Induced Hypotension in the Anaesthetized Dog

“…Priano, Traber and Wilson (1969) and Rosberg and Wulff (1979) found that prolonged pentobarbitone anaesthesia caused minimal further haemodynamic changes. Anaesthesia with fentanyl, droperidol and nitrous oxide is considered to maintain a stable cardiovascular function (Dobkin et al, 1970;Stoelting et al, 1975). The injection of droperidol and fentanyl to dogs anaesthetized with thiopentone, however, reduced CO because of a reduced heart rate (Irestedt and Andreen, 1979).…”

Συμβολη Εις Την Μελετην Της Νευροληπταναλγησιας Προναρκωσις Δια Thala- Monal

“…Έ π i τ ώ ν άλλων συστημάτων. Μελέται διαφόρων ερευ νητών αποδεικνύουν ότι το μίγμα των φαρμάκων υπό το όνομα Thalamonal ή Innovar, δεν έπιδρφ τοξικως επί των ζωτικών οργάνων, προκαλεί βαθεΐαν άναλγησίαν άνευ καρδιοαγγειακών διαταραχών εξασφαλίζον τήν μεγίστην περιφερικήν άρδευσιν των ίστων (Dobkin et al, 1970).…”

“…Ή νεφρική λειτουργία δέν παρεμποδίζεται υπό τοΰ\ Thalamonal, ώς απέδειξαν οί Dobkin et al (1970) επί 60 ασθενών, λαβόντων τοιαύτην άναι σθησίαν, κατόπιν μελέτης δειγμάτων αερίων αίματος καί ειδικών χημικών δο κιμασιών. 'Ωσαύτως, αί εργαστηριακοί μελέται των Martin et al (1967) απέ δειξαν οτι το Thalamonal δέν έχει τοξικήν έπίδρασιν επί του ήπατος, του αίματος καί των νεφρών.…”