Circulatory Effects of Inhalation Anaesthetics in Dogs and Horses

Steffey, Eugene

doi:10.1111/j.1467-2995.1982.tb00602.x

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Cardiac output continued to decrease during halothane anaesthesia, whereas it did not fall further with TIVA. This probably reflects the overriding myocardial depressant effect of halothane (Steffey & Howland, 1978;Steffey, 1982). The decrease in cardiac output during TIVA remained similar to that seen after a single 0.02 mg/kg of detomidine i.v.…”

Section: Discussionsupporting

confidence: 90%

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Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia

Luna

Taylor

Wheeler

1996

Vet Pharm & Therapeutics

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Six Welsh gelding ponies (weight 246 +/- 6 kg) were premedicated with 0.03 mg/kg of acepromazine intravenously (i.v.) followed by 0.02 mg/kg of detomidine i.v. Anaesthesia was induced with 2 mg/kg of ketamine i.v. Ponies were intubated and lay in left lateral recumbency. On one occasion anaesthesia was maintained for 2 h using 1.2% halothane in oxygen. The same group of ponies were anaesthetized 1 month later using the same induction regime and anaesthesia was maintained with a combination of detomidine, ketamine and guaiphenesin, while the ponies breathed oxygen-enriched air. Electrocardiogram, heart rate, mean arterial blood pressure, cardiac output, respiratory rate, blood gases, temperature, haematocrit, glucose, lactate and cortisol were measured and cardiac index and systemic vascular resistance were calculated in both groups. Beta-endorphin, met-enkephalin, dynorphin, arginine vasopressin (AVP), adrenocorticotrophic hormone (ACTH) and catecholamines were measured in the halothane anaesthesia group only and 11-deoxycortisol during total intravenous anaesthesia (TIVA) only. Cardiorespiratory depression was more marked during halothane anaesthesia. Hyperglycaemia developed in both groups. Lactate and AVP increased during halothane anaesthesia. Cortisol increased during halothane and decreased during TIVA. There were no changes in the other hormones during anaesthesia. Recovery was smooth in both groups. TIVA produced better cardiorespiratory performance and suppressed the endocrine stress response observed during halothane anaesthesia.

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Section: Discussionsupporting

confidence: 90%

“…The cardiorespiratory effects of each anaesthetic protocol were similar to those reported elsewhere with these anaesthetic agents (Steffey & Howland. 1978: Steffey, 1982: Taylor et al. 1992.…”

Section: Discussionmentioning

confidence: 99%

Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia

Luna

Taylor

Wheeler

1996

Vet Pharm & Therapeutics

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“…All four animals were operated o n in dorsal recumbency under halothane anaesthesia. Halothane anaesthesia has been shown t o reduce cardiac output in horses by an average of 50 per cent and mean arterial pressure by up to 31 per cent (Steffey 1982). Against this background it should be emphasised that relatively large numbers of young horses are operated on under halothane anaesthesia in dorsal recumbency with n o apparent untoward effects.…”

Section: Discussionmentioning

confidence: 99%

Spinal cord degeneration following general anaesthesia in a Shire horse

Brearley

Jones

Kelly

et al. 1986

Equine Veterinary Journal

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“…Atualmente o halotano é o anestésico inalatório mais popular, porém causa considerável depressão do sistema cardiovascular, já que reduz o débito cardíaco e a resistência vascular periférica, promovendo também a redução da pressão arterial e depressão dos barorrecptores em reposta à hipotensão arterial (STEFFEY, 1982).…”

Section: Introductionunclassified

Efeito Do Carbazocromo (Adrenoplasma) No Tratamento De Hipotensão Arterial Produzida Por Halotano Em Cães

Lorena¹,

Meneghello²,

Luna³

et al. 2009

Colloq Agrariae

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O halotano é um dos anestésicos inalatórios mais utilizados, porém produz depressão cardiovascular, tanto por deprimir o débito cardíaco como a resistência vascular periférica. Objetivou-se avaliar e comparar a eficácia de duas soluções: Ringer Lactato e solução de carbazocromo a 0,01% (adrenoplasma) no tratamento da hipotensão arterial.promovida pelo halotano, durante anestesia geral inalatória de cães. Doze animais adultos, machos e fêmeas, oriundos do Biotério central da UNESP, campus Botucatu, clinicamente saudáveis foram divididos, aleatoriamente, em dois grupos (n=6), sendo grupo A: animais que receberam infusão intravenosa de Adrenoplasma na velocidade de 20 ml/kg/hora e grupo B: animais que receberam infusão intravenosa de Ringer Lactato na mesma velocidade. Utilizou-se o propofol na dose de 6 mg/kg/IV para indução anestésica e após intubação foi fornecido 1,3V% de halotano para a manutenção por 90 minutos. Após 30 minutos iniciais, a infusão foi iniciada e perdurou pelos 60 minutos seguintes. A freqüência respiratória foi mantida constante. A freqüência cardíaca, eletrocardiograma, pressão arterial sistólica, média e disatólica, concentração final expirada de CO 2, volume corrente e minuto, saturação de pulso de oxigênio, tempo de sangramento e temperatura retal, foram avaliados antes e 30 minutos após a indução e, aos 15, 30, 45 e 60 minutos, após o inicio da fluidoterapia. Houve um aumento significativo nos valores de pressão arterial sistólica e média apenas nos animais que receberam Adrenoplasma em relação ao valor observado imediatamente antes do inicio da fluidoterapia. Não houve diferença no tempo d sangramento. Face ao observado, pode-se sugerir que o uso de Adrenoplasma, como opção de tratamento da hipotensão arterial, decorrente da anestesia inalatória com halotano.

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Circulatory Effects of Inhalation Anaesthetics in Dogs and Horses

Cited by 5 publications

References 35 publications

Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia

Cardiorespiratory, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anaesthesia

Spinal cord degeneration following general anaesthesia in a Shire horse

Efeito Do Carbazocromo (Adrenoplasma) No Tratamento De Hipotensão Arterial Produzida Por Halotano Em Cães

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