Circulatory Effects of Iothalamate Compounds (Conray) and Contrast Media of the Benzoic Acid Type

Systemic, Pulmonary and Renal Haemodynamic Effects of Large Intravenous Doses of High and Low Osmolar Contrast Media; An Investigation in the Pig of Ratio 1.5 and Ratio 3 Media

“…Since HR remained unchanged the increase of CO would appear to be secondary to an increased Sv. The increase of SV and CO might be partly explained by a plasma expansion due to the hyperosmolality (18) of the contrast media and a vasodilation of the resistance vessels (21). However, the absence of a significant difference between low and high osmolar media indicates that other factors, in addition to osmolality, probably are involved in the haemodynamic response to contrast media.…”

“…Although experimental results have to be conveyed in a clinical situation with great caution it might be that a small increase of MAP rather than decrease would be of great advantage when examining patients with cerebral or cardiovascular diseases. This is particularly true since ionic high osmolar media are known to reduce the arterial pressure (10,21).…”

Systemic, pulmonary and renal haemodynamic effects of large intravenous doses of high and low osmolar contrast media

“…Since H R remained unchanged the increase of CO would appear to be secondary to an increased SV. The increase of SV and CO might be partly explained by a plasma expansion due to the hyperosmolality (18) of the contrast media and a vasodilation of the resistance vessels (21). However, the absence of a significant difference between low and high osmolar media indicates that other factors, in addition to osmolality, probably are involved in the haemodynamic response to contrast media.…”

“…Although experimental results have to be conveyed in a clinical situation with great caution it might be that a small increase of MAP rather than decrease would be of great advantage when examining patients with cerebral or cardiovascular diseases. This is particularly true since ionic high osmolar media are known to reduce the arterial pressure (10,21). SVR depends not only on the tonus of the smooth muscle cells of the resistance vessels but also on the rheologic properties of blood.…”