Circulatory responses of malignant tumors during hyperthermia

Bicher, Haim I.; Mitagvaria, N

doi:10.1016/0026-2862(81)90002-9

Cited by 15 publications

(3 citation statements)

References 13 publications

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“…The specific circulatory changes depend in part on the extent of temperature elevation. With relatively small elevations of temperature, up to 41 O C, Bicher and Mitagvaria [5] observed an increase in blood flow with associated increases in tissue oxygen tensions. Emami and associates [6] reported a 50% decrease in blood flow in tumors at similar temperatures.…”

Section: Discussionmentioning

confidence: 96%

The effects of hyperthermia on vascular permeability in experimental liver metastasis

Lefor

Makohon

Ackerman

1985

Journal of Surgical Oncology

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The effects of hyperthermia on vascular permeability in Walker carcinosarcomas and host liver tissue were studied in Sprague-Dawley rats. A quantitative Evans blue technique was used to measure permeability. With tumors heated to 40 degrees C, a nontherapeutic level, no changes in tumor vascular permeability as compared to control levels were noted. However, with tumors heated to 43 degrees C, within the therapeutic range of hyperthermia, significant rises in tumor vascular permeability occurred. Permeability was increased at both time periods studied, 30 minutes and 6 hours after hyperthermia and injection of Evans blue. These changes are similar to those seen after physical damage from freeze-thaw. It is likely that alterations in tumor microcirculation play a role in the therapeutic effect of intense hyperthermia.

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Section: Discussionmentioning

confidence: 96%

The effects of hyperthermia on vascular permeability in experimental liver metastasis

Lefor

Makohon

Ackerman

1985

Journal of Surgical Oncology

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“…However, unlike normal tissue, not all tumors were able to increase their blood flow rate during hyperthermia. Bicher et al [40,41] reported that tumor blood flow in C3H mice increased up to 40-418C and then decreased at temperatures above this. In contrast, Robinson et al [42] found no significant change in tumor blood flow from 37.5 to 448C.…”

Section: Discussionmentioning

confidence: 96%

Docetaxel and hyperthermia: Factors that modify thermal enhancement

Mohamed¹,

Stuart²,

Gléhen³

et al. 2004

Journal of Surgical Oncology

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“…Heating increases the cells sensitivity to radiation [43, 44]. This effect occurs because of the increase of blood flow that drives the tissue oxygenation enrichment and the momentary enhancement of radio sensitivity by facilitating formations of oxygen radical [3, 45, 46]. The enhancement of oxygenation in a tumor has been proved in the clinical trial done by Brizel et al [47].…”

Section: Introductionmentioning

confidence: 99%

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

2017

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Current clinically accepted technologies for cancer treatment still have limitations which lead to the exploration of new therapeutic methods. Since the past few decades, the hyperthermia treatment has attracted the attention of investigators owing to its strong biological rationales in applying hyperthermia as a cancer treatment modality. Advancement of nanotechnology offers a potential new heating method for hyperthermia by using nanoparticles which is termed as magnetic fluid hyperthermia (MFH). In MFH, superparamagnetic nanoparticles dissipate heat through Néelian and Brownian relaxation in the presence of an alternating magnetic field. The heating power of these particles is dependent on particle properties and treatment settings. A number of pre-clinical and clinical trials were performed to test the feasibility of this novel treatment modality. There are still issues yet to be solved for the successful transition of this technology from bench to bedside. These issues include the planning, execution, monitoring and optimization of treatment. The modeling and simulation play crucial roles in solving some of these issues. Thus, this review paper provides a basic understanding of the fundamental and rationales of hyperthermia and recent development in the modeling and simulation applied to depict the heat generation and transfer phenomena in the MFH.

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Circulatory responses of malignant tumors during hyperthermia

Cited by 15 publications

References 13 publications

The effects of hyperthermia on vascular permeability in experimental liver metastasis

The effects of hyperthermia on vascular permeability in experimental liver metastasis

Docetaxel and hyperthermia: Factors that modify thermal enhancement

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

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