Circumpolar adaptation, social change, and the development of autoimmune thyroid disorders among the Yakut (Sakha) of Siberia

Cepon, Tara J.; Snodgrass, J. Josh; Leonard, William R.; Tarskaia, Larissa A.; Климова, Т.М.; Федорова, В. И.; Baltakhinova, Marina E.; Krivoshapkin, Vadim G.

doi:10.1002/ajhb.21200

Cited by 29 publications

(34 citation statements)

References 39 publications

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“…Exposure to an environment of inferior prosperity and hygiene is protective against the development of thyroid autoimmunity, compatible with the ‘hygiene hypothesis’ in which enhanced exposure to microbes in general skews the immune system away from the tendency to produce autoreactivity [55]. Another hint that certain environments can increase the risk of thyroid autoimmunity comes from a survey of the Yakut in Siberia; women there have an unexpectedly high frequency of thyroid autoantibodies which could be linked to circumpolar adaptation and recent changes in lifestyle [56]. Such analyses of the geoepidemiology of thyroid autoimmunity are few and far between, but this is a field that is ripe for development and with the potential to provide fresh insights into disease aetiology and pathogenesis [57].…”

Section: Non-genetic Factorsmentioning

confidence: 92%

The Immunopathogenesis of Chronic Autoimmune Thyroiditis One Century after Hashimoto

Weetman¹

2012

Eur Thyroid J

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Hakaru Hashimoto described 4 patients with a hitherto unknown cause for goitre, struma lymphomatosa, a century ago. He was careful to distinguish this from Riedel thyroiditis but it has become clear that fibrosis and atrophy of the thyroid are indeed components of Hashimoto thyroiditis, and in rare cases IgG4-related sclerosing disease may be an outcome. Although the cause of the lymphocytic infiltration was unknown to Hashimoto, we now know through the pioneering studies of N.R. Rose and E. Witebsky [J Immunol 1956;76:417–427] that this condition is the archetype for autoimmune destruction as a disease mechanism. In the last two decades in particular, there has been huge interest in unravelling the genetic basis for this and related autoimmune disorders. The list of polymorphisms associated with autoimmune thyroid disease grows each year, and in the case of vitiligo, which is frequently found in association with thyroid autoimmunity, we know that 27 separate susceptibility loci account for less than 20% of the heritability of this condition. Environmental and existential factors may turn out to be just as complex in number and in interactions. We can thus imagine a ‘Swiss cheese’ model for the causation of autoimmune thyroid disease, in which the effects of cumulative weaknesses line up – like the holes in slices of cheese – to allow the catastrophic event of autoimmune destruction to occur.

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Section: Non-genetic Factorsmentioning

confidence: 92%

The Immunopathogenesis of Chronic Autoimmune Thyroiditis One Century after Hashimoto

Weetman¹

2012

Eur Thyroid J

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“…Participants were interviewed in Russian on basic demographic and socioeconomic information including age, date of birth, education, and income. For more details, see Cepon et al (2011).…”

Section: Data Collectionmentioning

confidence: 98%

Do physical activity and sedentary behavior relate to cardio‐metabolic risk factor clustering in indigenous Siberian adults?

Wilson

Leonard

Tarskaia

et al. 2014

American J Hum Biol

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“…Traditional lifestyle has been associated with better health and is not mutually exclusive to dependence on the market economy within this population (Sorensen et al, 2005; Cepon et al, 2011). Whether participants had a traditional, marked‐based, or mixed lifestyle was determined using a Style of Life (SoL) index.…”

Section: Methodsmentioning

confidence: 99%

Socio‐demographic predictors of sleep complaints in indigenous Siberians with a mixed economy

Wilson

Климова

Knuston

et al. 2015

American J Phys Anthropol

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Objectives:Socio‐demographic indicators closely relate to sleep in industrialized populations. However we know very little about how such factors impact sleep in populations undergoing industrialization. Within populations transitioning to the global economy, the preliminary evidence has found an inconsistent relationship between socio‐demographics and sleep complaints across countries and social strata.Materials and methods:Surveys were conducted on a sample of rural Sakha (Yakut) adults (n = 168) during the autumn of 2103 to assess variation in socio‐demographics and sleep complaints, including trouble sleeping and daytime sleepiness. Socio‐demographic variables included age, gender, socioeconomic measures, and markers of traditional/market‐based lifestyle. We tested whether the socio‐demographic variables predicted sleep complaints using bivariate analyses and multiple logistic regressions.Results:Trouble sleeping was reported by 18.5% of the participants and excessive daytime sleepiness (EDS) by 17.3%. Trouble sleeping was significantly predicted by older age, female gender, and mixing traditional and market‐based lifestyles. EDS was not significantly predicted by any socio‐demographic variable.Discussion:These findings support the few large‐scale studies that found inconsistent relationships between measures of socioeconomic status and sleep complaints in transitioning populations. Employing a mix of traditional and market‐based lifestyles may leave Sakha in a space of vulnerability, leading to trouble sleeping. Am J Phys Anthropol 157:641–647, 2015. © 2015 The Authors. American Journal of Physical Anthropology Published by Wiley Periodicals, Inc.

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Circumpolar adaptation, social change, and the development of autoimmune thyroid disorders among the Yakut (Sakha) of Siberia

Abstract: Although preliminary, these findings document higher than expected TPOAb levels among Yakut women and suggest possible consequences of increased thyroid activity associated with circumpolar adaptation and social change.

Cited by 29 publications

References 39 publications

The Immunopathogenesis of Chronic Autoimmune Thyroiditis One Century after Hashimoto

The Immunopathogenesis of Chronic Autoimmune Thyroiditis One Century after Hashimoto

Do physical activity and sedentary behavior relate to cardio‐metabolic risk factor clustering in indigenous Siberian adults?

Socio‐demographic predictors of sleep complaints in indigenous Siberians with a mixed economy

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