Circumscribed Palmoplantar Hypokeratosis

Thirty years of new entities in inflammatory dermatology and dermatopathology

“…First described in 2002, it presents with a well-circumscribed annular, erosion-like plaque with depressed surface, rimmed by a hyperkeratotic border on the thenar or hypothenar eminences of the palm of middle-aged or elderly women. 4 Histopathology is characteristic of an abrupt and markedly decreased thickness of the horny layer (hypokeratosis) compared with the adjacent normal epidermis. A disorder of epidermal differentiation/keratinization has been suggested.…”