Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics

Che, Gang; Yin, Jie; Wang, Wankun; Luo, Yandong; Chen, Yiran; Yu, Xiongfei; Wang, Haiyong; Liu, Xiaosun; Chen, Zhendong; Wang, Xing; Chen, Yu; Wang, Xujin; Tang, Kaicheng; Tang, Jiao; Shao, Wei; Wu, Chao; Sheng, Jianpeng; Li, Qing; Liu, Jian

doi:10.1016/j.drup.2024.101080

Drug Resistance Updates

2024

DOI: 10.1016/j.drup.2024.101080

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Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics

Gang Che,

Jie Yin,

Wankun Wang

et al.

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2024

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Cited by 10 publications

References 56 publications

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Tissue‐Resident Macrophages in Cancer: Friend or Foe?

Chi,

Gao,

Liu

2024

Cancer Medicine

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IntroductionMacrophages are essential in maintaining homeostasis, combating infections, and influencing the process of various diseases, including cancer. Macrophages originate from diverse lineages: Notably, tissue‐resident macrophages (TRMs) differ from hematopoietic stem cells and circulating monocyte‐derived macrophages based on genetics, development, and function. Therefore, understanding the recruited and TRM populations is crucial for investigating disease processes.MethodsBy searching literature databses, we summarized recent relevant studies. Research has shown that tumor‐associated macrophages (TAMs) of distinct origins accumulate in tumor microenvironment (TME), with TRM‐derived TAMs closely resembling gene signatures of normal TRMs.ResultsRecent studies have revealed that TRMs play a crucial role in cancer progression. However, organ‐specific effects complicate TRM investigations. Nonetheless, the precise involvement of TRMs in tumors is unclear. This review explores the multifaceted roles of TRMs in cancer, presenting insights into their origins, proliferation, the latest research methodologies, their impact across various tumor sites, their potential and strategies as therapeutic targets, interactions with other cells within the TME, and the internal heterogeneity of TRMs.ConclusionsWe believe that a comprehensive understanding of the multifaceted roles of TRMs will pave the way for targeted TRM therapies in the treatment of cancer.

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Tissue‐Resident Macrophages in Cancer: Friend or Foe?

Chi,

Gao,

Liu

2024

Cancer Medicine

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siRNA-based strategies to combat drug resistance in gastric cancer

Khaleel,

Alshahrani,

Rizaev

et al. 2024

Med Oncol

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Spatial oncology: Translating contextual biology to the clinic

Gong,

Arbesfeld-Qiu,

Perrault

et al. 2024

Cancer Cell

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Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics

Cited by 10 publications

References 56 publications

Tissue‐Resident Macrophages in Cancer: Friend or Foe?

Tissue‐Resident Macrophages in Cancer: Friend or Foe?

siRNA-based strategies to combat drug resistance in gastric cancer

Spatial oncology: Translating contextual biology to the clinic

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