Cirrhosis and mortality risks of biopsy‐verified alcoholic pure steatosis and steatohepatitis: a nationwide registry‐based study

Deleuran, Thomas; Grønbæk, Henning; Vilstrup, Hendrik; Jepsen, Peter

doi:10.1111/j.1365-2036.2012.05091.x

Cited by 59 publications

(42 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a recent animal study indicates immune dysfunction even in dietary fatty livers (48). Also, with the progression from alcoholic steatosis to AH both the overall mortality (5-yr mortality; 17 vs. 56%) and the fraction of deaths attributed to infections increase (0.4 vs. 15%), which seems to point mostly at the former possibility (8,16,37,44).…”

Section: Discussionmentioning

confidence: 93%

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

Støy

Dige

Sandahl

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

The dynamics and role of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and NKT cells in the life-threatening inflammatory disease alcoholic hepatitis is largely unknown. These cells directly kill infected and damaged cells through, e.g., degranulation and interferon-γ (IFNγ) production, but cause tissue damage if overactivated. They also assist tissue repair via IL-22 production. We, therefore, aimed to investigate the frequency, functionality, and activation state of such cells in alcoholic hepatitis. We analyzed blood samples from 24 severe alcoholic hepatitis patients followed for 30 days after diagnosis. Ten healthy abstinent volunteers and 10 stable abstinent alcoholic cirrhosis patients were controls. Using flow cytometry we assessed cell frequencies, NK cell degranulation capacity following K562 cell stimulation, activation by natural killer group 2 D (NKG2D) expression, and IL-22 and IFNγ production. In alcoholic hepatitis we found a decreased frequency of CTLs compared with healthy controls (P < 0.001) and a similar trend for NK cells (P = 0.089). The NK cell degranulation capacity was reduced by 25% compared with healthy controls (P = 0.02) and by 50% compared with cirrhosis patients (P = 0.04). Accordingly, the NKG2D receptor expression was markedly decreased on NK cells, CTLs, and NKT cells (P < 0.05, all). The frequencies of IL-22-producing CTLs and NK cells were doubled compared with healthy controls (P < 0.05, all) but not different from cirrhosis patients. This exploratory study for the first time showed impaired cellular cytotoxicity and activation in alcoholic hepatitis. This is unlikely to cause hepatocyte death but may contribute toward the severe immune incompetence. The results warrant detailed and mechanistic studies.

show abstract

Section: Discussionmentioning

confidence: 93%

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

Støy

Dige

Sandahl

et al. 2015

American Journal of Physiology-Gastrointestinal and Liver Physi

View full text Add to dashboard Cite

show abstract

“…Once alcoholic hepatitis has developed, the risk of cirrhosis is increased compared with simple steatosis. In one study, over a five-year period, cirrhosis developed in 16 percent of patients with steatohepatitis and in 7 percent of patients with simple steatosis 10 . A subset of patients with ALD will develop severe AH, which often presents acutely against a background of chronic liver disease and has a substantially worse short-term prognosis 11 .…”

Section: Spectrum Of Alcoholic Liver Diseasementioning

confidence: 99%

The Impact of Obesity and Metabolic Syndrome on Alcoholic Liver Disease

Chiang

McCullough

2014

Clinics in Liver Disease

View full text Add to dashboard Cite

“…A significantly higher prevalence of cirrhosis in female AFLD patients was observed in a Danish study and time to cirrhosis was associated with female gender [10]. Population based studies have shown increased risk of women developing alcoholinduced cirrhosis [23][24][25][26].…”

Section: Liver-related Morbidity and Mortalitymentioning

confidence: 90%

937 Long Term Follow-up and Liver-Related Death Rate in Patients With Non-Alcoholic and Alcoholic Related Fatty Liver Disease

Hafliðadóttir¹,

Jónasson²,

Björnsson³

2012

Gastroenterology

View full text Add to dashboard Cite

Background: Few studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). We aimed to investigate the etiology and liver-related mortality of patients with liver biopsy verified fatty liver disease in a population based setting. Methods: In this retrospective study, all patients who underwent a liver biopsy 1984-2009 at the National University Hospital of Iceland were identified through a computerized pathological database with the code for fatty liver. Only patients with NAFLD and AFLD were included and medical records reviewed. The patients were linked to the Hospital Discharge Register, the Causes of Death Registry and Centre for Addiction Medicine.

show abstract

Cirrhosis and mortality risks of biopsy‐verified alcoholic pure steatosis and steatohepatitis: a nationwide registry‐based study

Cited by 59 publications

References 24 publications

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis

The Impact of Obesity and Metabolic Syndrome on Alcoholic Liver Disease

937 Long Term Follow-up and Liver-Related Death Rate in Patients With Non-Alcoholic and Alcoholic Related Fatty Liver Disease

Contact Info

Product

Resources

About