Cirrhosis of the liver following infectious mononucleosis

Leibowitz, Sidney; Brody, Henry

doi:10.1016/0002-9343(50)90313-5

Cited by 37 publications

(2 citation statements)

References 42 publications

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“…Unlike other forms of viral hepatitis, chronic hepatitis does not occur and complications are self-limiting in EBY infection. Acute liver failure, chronic hepatitis, and cirrhosis of the liver have rarely been reported in patients with EBY infection (3,(8)(9)(10). Histologic examination of the liver in the present case showed not only heavy mononuclear cell infiltration but also moderate fibrosis in the portal and perilobular areas.…”

Section: Discussionmentioning

confidence: 99%

Chronic Hepatitis Associated with Epstein‐Barr Virus Infection in an Infant

Tanaka,

Shimada,

Sasahara

et al. 1986

J. pediatr. gastroenterol. nutr.

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Summary: A 1‐year‐old infant girl had a chronic illness characterized by persistent intermittent fever, thrombocytopenia, granulocytopenia, and marked hepatosplenomegaly. Histological findings on liver biopsy 307 days after the onset of her illness disclosed marked mononuclear cell infiltration and moderate fibrosis in the portal and perilobular areas. Interferon‐therapy induced no clinical and laboratory improvement, whereas the patient's clinical and biochemical findings responded to prednisone. Although these findings suggested a possible autoimmune mechanism, there were no significant findings in extensive immunological and serological tests consistent with autoimmune disease. The profile of antibodies to Epstein‐Barr virus (EBV)‐specific antigens in the patient demonstrated that this prolonged atypical illness was the result of persistent EBV infection.

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Section: Discussionmentioning

confidence: 99%

Chronic Hepatitis Associated with Epstein‐Barr Virus Infection in an Infant

Tanaka,

Shimada,

Sasahara

et al. 1986

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

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“…It has long been known that jaundice sometimes occurs in in fectious mononucleosis (presumed to be viral), and that hepatic morphological and biochemical changes were fairly common, but a report of the developent of cirrhosis is fairly recent (118). The cirrhosis was of the small nodule type.…”

Section: Cirrhosis Of Infectious Mononucleosismentioning

confidence: 99%