Cirrhosis of the Liver induced in Rabbits by Gastric Instillation of 3-Monohydroxycholanic Acid

Holsti, Paul

doi:10.1038/186250a0

Cited by 88 publications

(25 citation statements)

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“…Thus the conjugation of bile acids, as reflected in serum levels, shows a good capacity for conjugating bile acids with the amino acids glycine and taurine in the liver at a time when total bile acids are increased. This is probably one protective factor against the toxicity of bile acids which has been demonstrated in animal experiments (2,(11)(12)(13)(14)18). The tendency of unconjugated bile acid levels in serum to increase with age is probably due to increasing deconjugation by intestinal bacterial flora (1 7).…”

Section: Discussionmentioning

confidence: 98%

Studies on the Conjugating Activity of Bile Acids in Children

Niijima

1985

Pediatr Res

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Section: Discussionmentioning

confidence: 98%

Studies on the Conjugating Activity of Bile Acids in Children

Niijima

1985

Pediatr Res

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“…In any event, lithocholic acid has been isolated from the bile and feces of normal subjects in significant amounts (13)(14)(15)(16), and alterations in the degradative pathway of cholesterol could lead to excessive production of this highly toxic metabolite. Although there is no present evidence of the participation of this pyrogenic and inflammatory steroid in clinical disease, it is of interest that this compound can produce experimental cirrhosis of the liver in other species (17)(18)(19).…”

Section: Methods and Resultsmentioning

confidence: 99%

Pyrogenic and Inflammatory Properties of Certain Bile Acids in Man*

Palmer¹,

Glickman²,

Kappas³

1962

J. Clin. Invest.

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This is a report on the pyrogenic and inflammatory properties of certain bile acids in man. The study was prompted by the structural similarity between these acidic steroids and the pyrogenic neutral steroids described previously (2-7). In addition, it seemed important to establish whether the large quantities of steroid acids formed during the metabolism of cholesterol could serve as a source of endogenous compounds having fever-producing action in man. METHODS AND RESULTSNineteen bile acids and derivatives were examined for fever-producing activity after their intramuscular administration to adult volunteer hospital patients. Lithocholic acid was repeatedly recrystallized to insure purity. The glycine, taurine, and acetyl derivatives of lithocholic acid were synthesized and purified in these laboratories; the other compounds were obtained commercially and used without additional purification. All bile acids were dissolved in propylene glycol, in concentrations of 12.5 and 25.0 mg per ml, and because of their acidity these solutions were neutralized with dilute base. The general details of the study, including precautions taken to exclude bacterial pyrogen contamination, were similar to those described in a previous report (3). The compounds examined, together with the incidence of pyrogenic responses which followed their injection, are listed below.

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“…Feeding lithocholate (a secondary bile acid) to animals causes hepatocellular and bile duct alterations which progress to cirrhosis [12,18,28]. Abnormally high lithocholate levels in serum have been found in humans with cirrhosis [6].…”

Section: Introductionmentioning

confidence: 99%

Primary and Secondary Bile Acids in Meconium

et al. 1971

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ExtractMeconium, newborn stool, and fetal bile were examined for bile acids by the techniques of gas liquid chromatography, thin layer chromatography and colorimetric spectrometry. Cholic, 1 chenodeoxycholic, deoxycholic, and lithocholic acid were detected in meconium. Secondary bile acids were not present in significant amounts in either stool or fetal bile from newborns. During fetal development more chenodeoxycholate than cholate is formed. The presence of secondary bile acids in meconium is suggestive of maternal-to-fetal transfer via the placenta.

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Cirrhosis of the Liver induced in Rabbits by Gastric Instillation of 3-Monohydroxycholanic Acid

Cited by 88 publications

References 1 publication

Studies on the Conjugating Activity of Bile Acids in Children

Studies on the Conjugating Activity of Bile Acids in Children

Pyrogenic and Inflammatory Properties of Certain Bile Acids in Man*

Primary and Secondary Bile Acids in Meconium

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