Cirrus High-Definition Optical Coherence Tomography Compared with Stratus Optical Coherence Tomography in Glaucoma Diagnosis

Moreno-Montañés, Javier; Olmo, Natalia; Alvarez, Aurora; García, Noelia; Zarranz‐Ventura, Javier

doi:10.1167/iovs.08-2988

Cited by 83 publications

(74 citation statements)

References 30 publications

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“…CpRNFL scans for assessing glaucoma do not take the full advantages offered by using SD-OCT. SD-OCT offers the ability to take wide regional RNFL measurements with high scan speed and resolution. Therefore, previous studies using the circumpapillary method for evaluating localized RNFL defects or early glaucoma detection reported similar discriminating abilities between time domain OCT and SD-OCT. 7,8,23,24 Analysis of RNFL maps is a proper way to exploit the advantages of SD-OCT. Leung et al 5 reported that a scoring system, which is designed to analyze the RNFL deviation map, significantly improves the diagnostic sensitivity for glaucoma detection at a high level of specificity when compared with cpRNFL measurements. In our study, the significance map and the thickness map showed a superior performance for detecting the localized RNFL Abbreviations: GCC, ganglion cell complex; GCL, ganglion cell layer; IPL, inner plexiform layer; NFL, nerve fiber layer; RNFL, retinal nerve fiber layer.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic ability of retinal nerve fiber layer maps to detect localized retinal nerve fiber layer defects

Shin

Uhm

Lee

et al. 2013

Eye

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Purpose To evaluate and compare the diagnostic ability of spectral domain optical coherence tomography (SD-OCT) for detecting localized retinal nerve fiber layer (RNFL) defects in topographic RNFL maps and circumpapillary RNFL (cpRNFL) thickness measurements. Methods Sixty-four eyes with localized RNFL defects in red-free RNFL photographs and 72 healthy eyes were included. All participants were imaged with SD-OCT. The area and angular width of the localized RNFL defects were measured with ImageJ software on RNFL thickness map, significance map (yellow pixels, o5% level), and red-free RNFL photographs. The sensitivity, specificity, and area under the receiver operating characteristic curves (AUCs) were calculated for cpRNFL thickness, macular inner retina thickness, and RNFL maps (thickness, significance) according to the quantitative measurements and a o5% level of classification to distinguish eyes with localized RNFL defects from healthy eyes. Results RNFL thickness map (sensitivity 96.9-98.4%, specificity 86.1-98.6%, and AUCs 0.915-0.992) and significance map (sensitivity 96.9-98.4%, specificity 88.9-95.8%, and AUCs 0.937-0.983) showed superior performance in detecting localized RNFL defects compared with other parameters (P-value 0.001-0.024) except for 36 sector cpRNFL thickness (sensitivity 92.2%, specificity 87.5%, and AUCs 0.898; P-value 0.080-0.545). The sensitivity for detecting RNFL defects was related to the angular width, area, and depth of the RNFL defects in the cpRNFL (4 sector, 12 sector) and macular inner retinal measurements. RNFL thickness and significance maps showed a constant sensitivity regardless of variations in angular width, area, and depth of the RNFL defects. Conclusion RNFL thickness and significance maps could be used to distinguish eyes with localized RNFL defects from healthy eyes more effectively than cpRNFL thickness and macular inner retina thickness measurements.

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Section: Discussionmentioning

confidence: 99%

Diagnostic ability of retinal nerve fiber layer maps to detect localized retinal nerve fiber layer defects

Shin

Uhm

Lee

et al. 2013

Eye

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“…However, the appearance of a new technology also implies the need of assessing its correlation with previous existing technologies. Several studies have evaluated the agreement between Cirrusand Stratus-OCT measurements in normal patients and patients with glaucoma, [16][17][18][19][20][21][22] nevertheless to our knowledge no previous studies have been published comparing RNFL thickness in patients with ON scanned with Stratus-OCT and Cirrus-OCT. As previously reported, 4-12 ON-eyes had significantly lower average RNFL thickness than fellow-eyes using both Stratus-and Cirrus-OCT (P ¼ 0.001).…”

Section: Discussionmentioning

confidence: 99%

“…This finding has been previously mentioned by other authors in glaucoma patients. 20 Cirrus-OCT assigned more ON-eyes as abnormal based on internal normative database (44.4 vs 38%). This might be because of the higher scan resolution and more accurate data registration of this instrument.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18][19][20][21][22] To our knowledge no previous studies have been published comparing the RNFL thickness in patients having ON with Stratus-OCT and Cirrus HD-OCT. The purpose of this study was to compare the RNFL measurements using Stratus-OCT and Cirrus HD-OCT in patients who had a previous episode of monocular ON to identify any differences.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Rebolleda

García-García²,

Kim³

et al. 2010

Eye

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Purpose To study the relationship between retinal nerve fiber layer (RNFL) thickness measurements from time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT) in subjects with optic neuritis. Methods A total of 18 patients who had suffered monocular acute optic neuritis were imaged by a single trained operator using the Stratus-OCT (fast RNFL scan mode) and Cirrus HD-OCT (optic disc cube mode) on the same day. The relationship between RNFL thickness measurements of the two OCTs (overall and by quadrants) were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman plots. Comparisons between eyes having optic neuritis (ON-group) and fellow eyes (fellow-group) were assessed by a generalized estimating equation (GEE) regression model.

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“…In addition to measuring average cpRNFL thickness changes, it is also important to consider localized RNFL loss, in particular in the superotemporal and inferotemporal sectors, which are the most frequently regions affected in the early stages of glaucoma (Lisboa et al, 2012;Moreno-Montañés et al, 2010;Park et al, 2009;Sehi et al, 2009). cpRNFL thinning in the superotemporal and inferotemporal sectors tends to have the best diagnostic performance in early disease (Lisboa et al, 2012).…”

Section: Detecting Structural Changementioning

confidence: 99%

Strategies to improve early diagnosis in glaucoma

Tatham¹,

Medeiros²,

Zangwill³

et al. 2015

Progress in Brain Research

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Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, functional abnormalities are detected first. This review describes recent innovations with the potential to improve the early detection of glaucoma. Developments in imaging include novel optic nerve head metrics such as Bruch's membrane opening-minimum rim width, enhanced ability to quantify inner layers of the glaucomatous macula, and ability to image deep optic nerve head structures, including the lamina cribrosa. Developments in detection of early glaucomatous functional loss include novel perimetric tests using frequency-doubling technology and flicker-defined form stimuli. Methods to combine results of structural and functional assessments are also presented that may improve early detection of glaucoma. KeywordsGlaucoma, Optical coherence tomography, OCT, Perimetry, Spectral domain, Early diagnosis Glaucoma is a leading cause of blindness, affecting more than 70 million people worldwide, of whom approximately 10% are bilaterally blind (Quigley and Broman, 2006). Glaucomatous visual losses can be prevented with early diagnosis and treatment; however, affected individuals are typically asymptomatic until later stages of the disease and a large proportion of those affected remain undiagnosed. Population-level surveys suggest only 10-50% of people with glaucoma are aware that they have the condition and consequently there are a large number of people Progress in Brain Research, Volume 221, ISSN 0079-6123, http://dx

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Cirrus High-Definition Optical Coherence Tomography Compared with Stratus Optical Coherence Tomography in Glaucoma Diagnosis

Cited by 83 publications

References 30 publications

Diagnostic ability of retinal nerve fiber layer maps to detect localized retinal nerve fiber layer defects

Diagnostic ability of retinal nerve fiber layer maps to detect localized retinal nerve fiber layer defects

Comparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis

Strategies to improve early diagnosis in glaucoma

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