Drug interactions occur when one or more medications are used simultaneously or close together, and the dentist is a healthcare professional responsible for prescribing. It is their responsibility to have the necessary knowledge to minimize, intervene, and prevent the effects of drug combinations, as well as their associations with alcohol, tobacco, herbal remedies, and foods. For the preparation of this work, tools such as the Repository of the University of Porto, the Institutional Repository of UniGuairacá University Center, the UFU Institutional Repository, the Journal of Oral and Maxillofacial Surgery from the University of Pernambuco, the Regional Portal of the Virtual Health Library (BVS), Google Scholar, PubMed, SciELO, LILACS, and the Minha Biblioteca platform from Patos de Minas College were used. In view of the adverse effects caused by drug interactions in the field of dental clinics, this review aims to demonstrate the relevance of instruction by the dentist, as well as their responsibility, in order to prevent the combination of medications, including those commonly used by patients, which could pose health risks.