Cis- and Trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells

Park, Hyo‐Sang; Vick, Eric; Gao, Ying; He, Chunnian; Almosnid, Nadin; Farone, Mary B.; Farone, Anthony L.

doi:10.1016/j.jep.2016.05.042

Cited by 14 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resveratrol was discovered as phytoalexin and has a variety of pharmacological activities, such as anti-pathogenic activities toward microorganisms (bacteria, fungi and viruses) and anti-tumor and anti-inflammatory activities. Some studies have suggested that some of these oligomers have significantly stronger antioxidant, antitumor and anti-inflammatory activities than their monomer resveratrol and that the mechanisms are also different; these properties have inspired scholars to look for new drug candidates with high selectivity and few side effects [10][11][12]. However, there is still no effective total synthesis method because of their structural complexity.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

Cen

Liu

et al. 2019

BMC Chemistry

View full text Add to dashboard Cite

Background: Paeonia suffruticosa is an important traditional Chinese herb used to treat osteoarthritis (OA) and oligostilbenes are the main active ingredient of the seeds of P. suffruticosa. The monomer trans-resveratrol of this species was demonstrated to have chondroprotective effects as a lead compound for the treatment of osteoarthritis, but it has not been applied due to its low efficacy. Methods: Oligostilbenes were isolated by chromatography and were identified by NMR and HPLC. A rabbit osteoarthritis chondrocyte model was induced by interleukin-1β and was treated with individual drugs to systematically evaluate their effects. Cell Counting Kit 8 was used to test their effects on cell viability, calculate EC 50 and plot a doseresponse curve.Their effects on apoptosis were analyzed by Annexin V and PI staining, and the expression of chondrocyte-specific genes COL2A1, MMP13 and SOX9 was evaluated by real-time PCR. Results: Paeonia suffruticosa seed extract could promote the cell viability of rabbit OA chondrocytes at low concentration and then ten oligostilbenes were isolated from it. Trans-oligostilbenes were better than their cis-forms, trimers and dimers were better than monomers for promoting the cell viability of rabbit osteoarthritis chondrocytes. None of the oligostilbenes was more effective than seed extract at the appropriate concentration; 1 μM oligostilbenes all showed various anti-apoptotic effects. Trans-gnetin H showed the best effect on proliferation and inhibition of MMP13 expression on OA chondrocytes, while trans-viniferin was most effective in promoting the expression of COL2A1 and SOX9. Conclusions: Ten oligostilbenes from P. suffruticosa seed all have certain protective effects on OA chondrocytes at low concentration. The trans-viniferin and some trimers have the potential to be further developed for the treatment of osteoarthritis because they were more effective than resveratrol and diacerein. The synergistic effect that may exist between oligostilbenes also warrants further research.

show abstract

Section: Introductionmentioning

confidence: 99%

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

Cen

Liu

et al. 2019

BMC Chemistry

View full text Add to dashboard Cite

show abstract

“…This was the first report on the large-scale extraction, enrichment and separation of oligostilbenes. The results of pharmacological studies revealed that SB, TV and TG had good antioxidant [5] , antibacterial [9] , anti-inflammatory [10] , [11] , anti-tumor [4] , [9] , [12] , cognitive function improvement [13] , hypoglycemic effects [4] , enzyme inventory activity [4] , etc. The SOP in this paper could produce high purity SB, TV and TG, and provided theoretical support for PSS as a new resource of oligostilbenes.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, SB, TV and TG had the highest content with important development and utilization value [3] , [7] , [8] . The bioactivities evaluation revealed that SB, TV and TG had good antioxidant [5] , antibacterial [9] , anti-inflammatory [10] , [11] , anti-tumor [4] , [9] , [12] , cognitive function improvement [13] , hypoglycemic effects [4] , enzyme inventory activity [4] , etc. As a kind of authorized edible oil, tree peony seed oil (TPSO) was widely concerned for its rich content of unsaturated fatty acids, which led to the increasing cultivation area of oil tree peony year by year [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic-assisted extraction and adsorption separation: Large-scale preparation of trans-ε-Viniferin, suffruficosol B and trans-Gnetin H for the first time

Deng

Wang²,

Hou³

et al. 2022

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

“…However, studies have shown that activation of the NF-κB or JNK/P38 MAPK signaling pathway is an important way to induce high expression of IL8 . JAK-STAT3 is an upstream signaling molecule for NF-κB activation, which induces the expression of IL8. , P38/JNK MAPK, NF-κB, and JAK-STAT3 signaling pathways play vital roles in other inflammatory skin diseases, such as psoriasis and rosacea . One study reported that transgenic mice (K5.…”

Section: Discussionmentioning

confidence: 99%

P38 MAPK, NF-κB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression

Wang

et al. 2022

Chem. Res. Toxicol.

View full text Add to dashboard Cite

Hand-foot syndrome (HFS) is a major adverse reaction to capecitabine (CAP). The exact pathogenesis of this disease remains unclear. In this study, metabolomics combined with cell RNA sequencing was used to study the mechanisms of CAP-induced HFS. The murine model of HFS was constructed by intragastric administration of CAP or its metabolites. Quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assays were used to verify the mechanisms. Metabolomics showed the phosphatidylinositol signaling pathway and amino acid and fatty acid metabolism to be the major metabolic alterations related to the occurrence of HFS. Transcriptomics profiles further revealed that the cytokine–cytokine receptor interaction, IL17 signaling pathway, Toll-like receptor signaling pathway, arachidonic acid metabolism, MAPK signaling pathway, and JAK-STAT3 signaling pathway were the vital steps in skin toxicity induced by CAP or its metabolites. We also verified that the inflammation mechanisms were primarily mediated by the abnormal expression of interleukin (IL) 6 or IL8 and not exclusively by COX-2 overexpression. Finally, the P38 MAPK, NF-κB, and JAK-STAT3 signaling pathways, which mediate high levels of expression of IL6 or IL8, were identified as potential pathways underlying CAP-induced HFS.

show abstract

Cis- and Trans-gnetin H from Paeonia suffruticosa suppress inhibitor kappa B kinase phosphorylation in LPS-stimulated human THP-1 cells

Cited by 14 publications

References 42 publications

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

Ultrasonic-assisted extraction and adsorption separation: Large-scale preparation of trans-ε-Viniferin, suffruficosol B and trans-Gnetin H for the first time

P38 MAPK, NF-κB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression

Contact Info

Product

Resources

About