cis-Atracurium in dogs with and without porto-systemic shunts

Increases in heart rate and systolic blood pressure in anesthetized dogs affected with X‐linked muscular dystrophy after cisatracurium administration: a retrospective study

“…Reports of patients anesthetized with volatile agents or propofol infusions receiving cisatracurium do not associate cardiovascular changes with the administration of this NDNMB (10,11). In addition, the results of this study are in agreement with previous reports in which cisatracurium was administered to healthy mongrel dogs or dogs of different breeds affected with portosystemic shunt and did affect HR or blood pressure values (9,12). Similarly, only minor cardiovascular changes were observed in surgical patients not affected with DMD that received 2–5× ED 95 of cisatracurium (13).…”

Xylazine Premedication does not Modify the Onset and Duration of Cisatracurium Blockade in Anaesthetized Dogs

“…Xylazine is presumed to affect the onset time and duration of NMB via its effect on circulation or otherwise potentiation on neuromuscular junction. The time of onset of NMB after a dose of 0.1 mg kg −1 cisatracurium was reported as 6.2 ± 1.4 min in dogs after halothane (Adams et al., 2001) and 3.4 ± 0.7 min administration after isoflurane anaesthesia (Adams et al., 2006). The reason for the selection of a higher dose of cisatracurium in this study was the variability in response to 0.1 mg kg −1 reported by others (Adams et al., 2001, 2006).…”

“…The time of onset of NMB after a dose of 0.1 mg kg −1 cisatracurium was reported as 6.2 ± 1.4 min in dogs after halothane (Adams et al., 2001) and 3.4 ± 0.7 min administration after isoflurane anaesthesia (Adams et al., 2006). The reason for the selection of a higher dose of cisatracurium in this study was the variability in response to 0.1 mg kg −1 reported by others (Adams et al., 2001, 2006). However, the time of onset in this study was recorded as 3.25 ± 1.4 min in t and 2.55 ± 0.6 min in c group which is nearly similar to those results that were reported previously (Adams et al., 2006).…”

The Effect of Neuromuscular Blockade on Canine Laparoscopic Ovariectomy: A Double‐Blinded, Prospective Clinical Trial

“…Correct placement of the stimulating electrodes was verified before administration of NMB using TOF stimulation. TOF stimulation pattern is commonly used to monitor NMB in dogs and is accepted to be adequately sensitive . Double burst stimulation is recognized to be a more sensitive technique to measure NMB in people, but this technique has not been evaluated in dogs.…”