Cisatracurium - ein Stereoisomer als „ideales” Relaxans?

Abstract

In this study, with the particular time course of drug administration, neither cisatracurium nor vecuronium increased plasma histamine levels. Only after 5 x ED95 cisatracurium was 1 elevated histamine level documented after 5 min. In several studies increased histamine levels have been described, but without clinical manifestations. It is known that cutaneous signs can occur without increased plasma histamine levels due to the structural heterogeneity of mast cells. The cutaneous reactions in this study were caused by thiopentone. The tryptase values were within normal limits even in the patient with histamine release. No relationship between the positive results in the prick test and the incidence of cutaneous reactions and/or histamine release for drugs used in the induction of anaesthesia was observed. Whether cisatracurium has a potential for immunologic release is unknown.

Evaluation of the three different doses of cisatracurium during general anaesthesia: A prospective randomized study

“…Despite these benefits, cisatracurium has limited use as it exhibits a slower onset and less satisfactory intubating conditions compared with other neuromuscular blocking agents when used in equipotent doses. [ 1 2 ] Hence, we evaluated different doses of cisatracurium to assess its onset, intubating condition, and total duration of action.…”

“…Wheezing, bronchospasm, rash, and itching following cisatracurium administration are also found to be rare. [ 2 ]…”