Cisd2 plays an essential role in corneal epithelial regeneration

Sun, Chi-Chin; Lee, Shao-Yun; Kao, Cheng‐Heng; Chen, Li‐Hsien; Shen, Zhao-Qing; Lai, Chia-Yun; Tzeng, Tsai-Yu; Pang, Jong‐Hwei S.; Chiu, Wen‐Tai; Tsai, Ting‐Fen

doi:10.1016/j.ebiom.2021.103654

Cited by 15 publications

(10 citation statements)

References 40 publications

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“…Calcium is known to directly affect corneal epithelial cells through the cytosolic iron-sulfur cluster-binding protein, CDGSH Iron Sulfur Domain 2 (CISD2). Reduced levels of CISD2 in corneal cells leads to increased calcium dysregulation via calcineurin hyperactivity, the formation of reactive oxygen species (ROS), corneal epithelial defects, and decreased wound healing [38][39][40]. Interestingly, DED patients who take calcineurin inhibitor cyclosporine A have shown improved corneal epithelial integrity in CISD2 knockout mice and human DED trials [40].…”

Section: Discussionmentioning

confidence: 99%

Discovery and Detection of Dry Eye Disease Protein Biomarkers Using Soft Contact Lens Tear Sampling

Roden,

Jiang,

Nitz

et al. 2023

Preprint

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Dry eye disease (DED) affects up to half of the world's population and causes blur, eye pain, decreased quality of life. Unfortunately, many people do not receive proper treatment due to current challenges associated with DED diagnoses. To address this issue, point-of-care (PoC) clinical tear film diagnostics are beginning to be used for rapid in-office testing. However, these diagnostics also have significant obstacles, including challenges associated with tear sampling. We previously demonstrated how soft contact lenses (SCLs) can be used to capture and concentrate tear proteins on the eye. Given the low tear volume associated with DED subjects, SCL sampling holds great potential to improve DED PoC diagnostics and facilitate prompt treatment for patients. Here we show the detection of new and established DED protein biomarkers using our SCL sampling method. Our analysis revealed associations between DED tear proteins and the immune system, ferroptosis, salivary secretion, and calcium binding proteins. We also identified correlations between clinical DED testing and proteomics, emphasizing the power and importance of translational medicine research. These experiments lay the foundation for both SCL sampled tear protein biomarker discovery as well as improved diagnostic testing to improve DED patient care.

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Section: Discussionmentioning

confidence: 99%

Discovery and Detection of Dry Eye Disease Protein Biomarkers Using Soft Contact Lens Tear Sampling

Roden,

Jiang,

Nitz

et al. 2023

Preprint

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“…For instance, the overexpression of Cisd2 in an APP/PS1 transgenic mouse model for AD resulted in a neuroprotective effect, probably by preventing mitochondrial damage [ 150 ]. Conversely, a lack of Cisd2 can lead to chronic injury, such as that seen in the cornea of patients with epithelial disease [ 151 ]. A vicious cycle of aberrant wound healing, hindered by Ca 2+ dyshomeostasis and mitochondrial dysfunction, leads to the hyperproliferation and exhaustion of the corneal epithelial stem cells [ 151 , 152 ].…”

Section: Wolfram Syndromementioning

confidence: 99%

“…Conversely, a lack of Cisd2 can lead to chronic injury, such as that seen in the cornea of patients with epithelial disease [ 151 ]. A vicious cycle of aberrant wound healing, hindered by Ca 2+ dyshomeostasis and mitochondrial dysfunction, leads to the hyperproliferation and exhaustion of the corneal epithelial stem cells [ 151 , 152 ].…”

Section: Wolfram Syndromementioning

confidence: 99%

Dysregulated Ca2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer’s Disease and Wolfram Syndrome

Callens

Loncke

Bultynck

2022

Cells

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Calcium ions (Ca2+) operate as important messengers in the cell, indispensable for signaling the underlying numerous cellular processes in all of the cell types in the human body. In neurons, Ca2+ signaling is crucial for regulating synaptic transmission and for the processes of learning and memory formation. Hence, the dysregulation of intracellular Ca2+ homeostasis results in a broad range of disorders, including cancer and neurodegeneration. A major source for intracellular Ca2+ is the endoplasmic reticulum (ER), which has close contacts with other organelles, including mitochondria. In this review, we focus on the emerging role of Ca2+ signaling at the ER–mitochondrial interface in two different neurodegenerative diseases, namely Alzheimer’s disease and Wolfram syndrome. Both of these diseases share some common hallmarks in the early stages, including alterations in the ER and mitochondrial Ca2+ handling, mitochondrial dysfunction and increased Reactive oxygen species (ROS) production. This indicates that similar mechanisms may underly these two disease pathologies and suggests that both research topics might benefit from complementary research.

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“…The team of Ting-Fen Tsai emphasizes the importance of CISD2 in ageing by maintaining cellular homeostasis and propose novel therapeutic interventions that could promote CISD2 activity to tackle age-related disorders and to expand the lifespan of humans in healthy conditions [31]. Recently, loss of CISD2 has also been implicated as an underlying cause of dry eye disease in humans involving dysregulated intracellular Ca 2+ dynamics [32,33]. So, we hope you will enjoy this assembly of diverse articles exposing different aspects of cell death mechanisms, their contribution to cellular homeostasis and the high potential and strong promise of targeting these mechanisms to tackle several types of diseases and malignancies.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Introducing the Special Issue on “Death mechanisms in cellular homeostasis” in honor of Dr. Peter Ruvolo

Bultynck

2022

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Cisd2 plays an essential role in corneal epithelial regeneration

Cited by 15 publications

References 40 publications

Discovery and Detection of Dry Eye Disease Protein Biomarkers Using Soft Contact Lens Tear Sampling

Discovery and Detection of Dry Eye Disease Protein Biomarkers Using Soft Contact Lens Tear Sampling

Dysregulated Ca2+ Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer’s Disease and Wolfram Syndrome

Introducing the Special Issue on “Death mechanisms in cellular homeostasis” in honor of Dr. Peter Ruvolo

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