2022
DOI: 10.3390/cancers14143356
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CISH Expression Is Associated with Metastasis-Free Interval in Triple-Negative Breast Cancer and Refines the Prognostic Value of PDL1 Expression

Abstract: Strategies are being explored to increase the efficiency of immune checkpoint inhibitors (ICIs) targeting PD1/PDL1 in triple-negative breast cancer (TNBC), including combination with therapies inhibiting intracellular immune checkpoints such as CISH (Cytokine-induced SH2 protein). Correlation between CISH expression and TNBC features is unknown. We retrospectively analyzed CISH expression in 1936 clinical TNBC samples and searched for correlations with clinical variables, including metastasis-free interval (MF… Show more

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Cited by 2 publications
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“…Previous studies have reported diverse functions of CISH in different cell types. In T lymphocytes, CISH is induced after TCR stimulation and has been implicated as a good prognostic factor in triple-negative breast cancer 57,58 . In dendritic cell (DC), CISH is predominantly induced during DC development and plays a crucial role in type 1 DC development and DC-mediated T-cell activation 59 .…”
Section: Expressionmentioning
confidence: 99%
“…Previous studies have reported diverse functions of CISH in different cell types. In T lymphocytes, CISH is induced after TCR stimulation and has been implicated as a good prognostic factor in triple-negative breast cancer 57,58 . In dendritic cell (DC), CISH is predominantly induced during DC development and plays a crucial role in type 1 DC development and DC-mediated T-cell activation 59 .…”
Section: Expressionmentioning
confidence: 99%