Cisplatin and Hyperthermia Treatment of A C3H Mammary Carcinoma in Vivo: Importance of sequence, interval, drug dose, and temperature

Lindegaard, J.C.; Radačić, Marko; Khalil, Azza Ahmed; Horsman, Michael R.; Overgaard, Jens

doi:10.3109/02841869209108184

Cited by 19 publications

(12 citation statements)

References 14 publications

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“…51,52 It has been theorized that following tumor heating, absorbed fragments of necrotic cancer cells provide the antigenic stimulus needed to enhance the host immune system that then lead to the destruction of tumor cells. 53,54 In the present study, the most pronounced effect on animal survival was achieved with the combination of WSDP and cisplatin when combined with hyperthermia; the enhancement of cytotoxicity in combination with hyperthermia and synergistic activity of WSDP and cisplatin should be considered to be the case as was suggested by Orsolić et al 2 According to other findings by Lindegaard et al, 55 the synergistic effect between hyperthermia and cisplatin is the highest during simultaneous application as was also shown in this study. From our results, it is obvious that hyperthermia increased the sensitivity of tumor cells to cisplatin (chemo sensitization effect).…”

Section: Discussionsupporting

confidence: 81%

Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

Oršolić

Car

Lisičić

et al. 2013

Journal of Pharmaceutical Sciences

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Section: Discussionsupporting

confidence: 81%

Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

Oršolić

Car

Lisičić

et al. 2013

Journal of Pharmaceutical Sciences

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“…This is particularly important for HIPEC since this treatment increases the activity of the drugs (especially cisplatin) exerting a strong anticancer effect on one hand, while on the other hand it rapidly increases toxicity. This suggests the benefit of decreasing drug dosage or of its sequential application during a long period of time [37,42]. This is consistent with the knowledge that hyperthermia is an effective way of local drug delivery.…”

supporting

confidence: 79%

“…Thus, hyperthermia may have either a direct suppressive effect on tumor cells or it may act indirectly via enhanced host immune function [36]. In the present study, the most pronounced effect on animal survival was achieved with the combination of CPL and cisplatin when combined with hyperthermia; enhancement of cytotoxicity in combination with hyperthermia and synergistic activity of CPL and cisplatin should be considered to be the cause as was suggested by Kujundžić et al [8,37].…”

supporting

confidence: 57%

Prevention of Peritoneal Carcinomatosis in Mice by Combining Hyperthermal Intraperitoneal Chemotherapy with the Water Extract from Burr Parsley (Caucalis platycarposL.)

Oršolić

Bevanda²,

Kujundžić³

et al. 2009

Planta Med

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The presence of peritoneal carcinomatosis arising from gastrointestinal and gynecologic tumors is associated with a poor prognosis. Animal models of peritoneal carcinomatosis are important in the evaluation of new treatment modalities. The purpose of this study was to investigate the effect of local chemoimmunotherapy and hyperthermal intraperitoneal chemotherapy (HIPEC) in an animal model of induced peritoneal carcinomatosis in the mouse. For induction of peritoneal carcinomatosis, cells from transplantable mammary carcinoma (MCa) were implanted intraperitoneally in CBA mice. Seven or 3 days before implantation of MCa cells (5 x 10 (3)) the mice were injected with lyophilized water extract from CAUCALIS PLATYCARPOS L. (CPL; 200 mg . kg (-1)) into the abdominal cavity. Immediately after implantation of MCa cells in the abdominal cavity, mice were treated two times with 2 mL of saline that was heated either at 37 degrees C or 43 degrees C (hyperthermal treatment) and cytostatics (doxorubicin 20 mg . kg (-1), cisplatin 10 mg . kg (-1), mitomycin 5 mg . kg (-1), 5-FU 150 mg . kg (-1)). We followed the survival of animals and the side effects appearing with different forms of treatment. CPL increased the life span of mice with peritoneal carcinomatosis without hyperthermal treatment (ILS% = 32.55 %) but showed no effect on the life span of mice with hyperthermal treatment (ILS% = 1.44). Combined treatment with CPL and cytostatics (CIS, DOX, and MIT) significantly affected the development of peritoneal carcinomatosis and increased the survival of mice (ILS% - 37 degrees C = 144.17, 415.46, and 124.13, ILS% - 43 degrees C = 311.42, 200.74, and 138.33, respectively). However, intraperitoneal chemotherapy with 5-FU alone resulted in greater survival time of mice than the treatment with 5-FU + CPL. Results suggest the synergistic effect of hyperthermia, chemotherapy, and immunotherapy. CPL significantly increases the antitumor activity of the hyperthermic chemotherapy and the survival rate of mice with peritoneal carcinomatosis. The stimulative effect of CPL on immunomodulation may be a possible mechanism which protects mice from developing peritoneal carcinomatosis and reduces the side effects of chemotherapy, increasing the life span of mice.

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“…Heating at 40 • C potentiated the cytotoxicity of CT drugs in human maxillary carcinoma cells [28], and the cytotoxicity was further increased on heating to 43.5-44 • C [54]. In contrast, another preclinical study showed no such dependency at 41-43.5 • C [55]. An in vitro study showed that apoptosis in human keratinocytes occurred at temperatures of 39 • C and above [56].…”

Section: Heating Temperaturementioning

confidence: 99%

“…In contrast to RT, CT can be given simultaneously or immediately after or before HT [87]. A preclinical study, in which cisplatin and heat were used to treat C3H xenografts, showed that a higher additive effect can be obtained when cisplatin was given 15 min before HT in comparison with an interval longer than 4 h [55].…”

Section: Time Interval Parametermentioning

confidence: 99%

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

Ademaj

Veltsista

Ghadjar

et al. 2022

Cancers

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Hyperthermia (HT) is a cancer treatment modality which targets malignant tissues by heating to 40–43 °C. In addition to its direct antitumor effects, HT potently sensitizes the tumor to radiotherapy (RT) and chemotherapy (CT), thereby enabling complete eradication of some tumor entities as shown in randomized clinical trials. Despite the proven efficacy of HT in combination with classic cancer treatments, there are limited international standards for the delivery of HT in the clinical setting. Consequently, there is a large variability in reported data on thermometric parameters, including the temperature obtained from multiple reference points, heating duration, thermal dose, time interval, and sequence between HT and other treatment modalities. Evidence from some clinical trials indicates that thermal dose, which correlates with heating time and temperature achieved, could be used as a predictive marker for treatment efficacy in future studies. Similarly, other thermometric parameters when chosen optimally are associated with increased antitumor efficacy. This review summarizes the existing clinical evidence for the prognostic and predictive role of the most important thermometric parameters to guide the combined treatment of RT and CT with HT. In conclusion, we call for the standardization of thermometric parameters and stress the importance for their validation in future prospective clinical studies

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Cisplatin and Hyperthermia Treatment of A C3H Mammary Carcinoma in Vivo: Importance of sequence, interval, drug dose, and temperature

Cited by 19 publications

References 14 publications

Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

Synergism Between Propolis and Hyperthermal Intraperitoneal Chemotherapy with Cisplatin on Ehrlich Ascites Tumor in Mice

Prevention of Peritoneal Carcinomatosis in Mice by Combining Hyperthermal Intraperitoneal Chemotherapy with the Water Extract from Burr Parsley (Caucalis platycarposL.)

Clinical Evidence for Thermometric Parameters to Guide Hyperthermia Treatment

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