Cisplatin, tegafur, and leucovorin

Wang, Hung‐Ming; Wang, Cheng-Su; Chen, Jen‐Shi; Chen, I-How; Liao, Chun‐Ta; Chang, Tung-Chieh

doi:10.1002/cncr.10570

Cited by 59 publications

(20 citation statements)

References 37 publications

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“…Most retrospective studies of head and neck cancers included various subsites (Table 4). Some series revealed a significant rate of organ preservation with similar survival rates between surgery and chemo-radiotherapy in head and neck cancer patients [1,4,6-12,15,16,18,19,23-27], especially for laryngeal cancer. In this study, we separated the entire patient population into two main treatment groups: radical surgery or organ preservation.…”

Section: Discussionmentioning

confidence: 99%

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Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan

et al. 2010

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PurposeThe aim of this study was to evaluate treatment results in our hypopharyngeal cancer patients.Patients and MethodsA total of three hundred and ninety five hypopharyngeal cancer patients received radical treatment at our hospital; 96% were male. The majority were habitual smokers (88%), alcohol drinkers (73%) and/or betel quid chewers (51%). All patients received a CT scan or MRI for tumor staging before treatment. The stage distribution was stage I: 2 (0.5%); stage II: 22 (5.6%); stage III: 57 (14.4%) and stage IV: 314 (79.5%). Radical surgery was used first in 81 patients (20.5%), and the remaining patients (79.5%) received organ preservation-intended treatment (OPIT). In the OPIT group, 46 patients received radiotherapy alone, 156 patients received chemotherapy followed by radiotherapy (CT/RT) and 112 patients received concomitant chemo-radiotherapy (CCRT).ResultsThe five-year overall survival rates for stages I/II, III and IV were 49.5%, 47.4% and 18.6%, respectively. There was no significant difference in overall and disease-specific survival rates between patients who received radical surgery first and those who received OPIT. In the OPIT group, CCRT tended to preserve the larynx better (p = 0.088), with three-year larynx preservation rates of 44.8% for CCRT and 27.2% for CT/RT. Thirty-seven patients developed a second malignancy, with an annual incidence of 4.6%.ConclusionsThere was no survival difference between OPIT and radical surgery in hypopharyngeal cancer patients at our hospital. CCRT may offer better laryngeal preservation than RT alone or CT/RT. However, prospective studies are still needed to confirm this finding. Additionally, second primary cancers are another important issue for hypopharyngeal cancer management.

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Section: Discussionmentioning

confidence: 99%

“…The chemotherapy (CT) regimen, PTL, was detailed in our previous report [16]. In brief, it consists of 50 mg/m 2 cisplatin (P) on Day 1, followed by 800 mg/m 2 oral tegafur (T) per day and 60 mg oral leucovorin (L) per day for 14 days.…”

Section: Methodsmentioning

confidence: 99%

Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan

et al. 2010

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“…Concomitant chemotherapy consisted of intravenous cisplatin 50 mg/m 2 on day 1, and oral tegafur 800 mg/day plus oral leucovorin 60 mg/day from day 1 to day 14. This regimen was repeated every 2 weeks throughout the radiotherapy course [14]. Following treatment, all patients underwent a clinical follow-up examination every 1–3 months.…”

Section: Methodsmentioning

confidence: 99%

Cystic nodal metastasis in patients with oropharyngeal squamous cell carcinoma receiving chemoradiotherapy: Relationship with human papillomavirus status and failure patterns

et al. 2017

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ObjectivesWe investigated the relationships of cystic nodal metastasis, human papillomavirus (HPV) status, and treatment failure patterns in patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with chemoradiotherapy.MethodsWe retrospectively reviewed pretreatment MRI and clinical courses of patients with OPSCC whose tumors were tested for HPV-induced p16 expression via immunohistochemistry and who completed chemoradiotherapy. Cervical cystic nodal metastasis and necrotic nodal metastasis were classified on MRI.ResultsOf 98 patients eligible for analysis, 33 were p16-positive. Cystic nodal metastasis was significantly more prevalent in p16-positive than in p16-negative patients (39.4% versus 18.5%, respectively; p = 0.025). Necrotic nodal metastasis was significantly more prevalent in p16-negative than in p16-positive patients (73.8% versus 51.5%, respectively; p = 0.027). On multivariate analysis, necrotic nodal metastasis (odds ratio [OR] = 7.310, p = 0.011) was an independent predictor of regional failure, while advanced nodal stage (OR = 4.119, p = 0.022) and cystic nodal metastases (OR = 0.087, p = 0.026) were independent positive and negative predictors of distant failure, respectively.ConclusionsCervical cystic and necrotic nodal metastases are associated with HPV-induced p16-positive and p16-negative OPSCC, respectively. Patients with necrotic nodal metastasis at presentation have an increased risk of regional failure. Distant failure is directly and inversely correlated with advanced nodal stage and cystic nodal metastasis, respectively.

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“…For low dose cisplatin, the prescribed dose of cisplatin was 40–50 mg/m 2 weekly or biweekly, with or without additional oral 5-fluorouracil prodrug. [11], [12] For high dose cisplatin, the prescribed dose of cisplatin was 100 mg/m 2 triweekly. Chemotherapy was paused or reduced in dose if there were obvious complications.…”

Section: Methodsmentioning

confidence: 99%

Postoperative Concomitant Chemoradiotherapy Improved Treatment Outcomes of Patients with Oral Cavity Cancer with Multiple-Node Metastases but No Other Major Risk Factors

et al. 2014

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PurposeTo investigate the results of postoperative radiotherapy (PORT) for the treatment of pathologic N2b/c squamous cell carcinoma of the oral cavity (OSCC).Materials and MethodsThis study reviewed cancer registry data collected in our hospital from 1998 to 2009 with the following inclusion criteria: primary OSCC, treatment with radical surgery, and multiple nodal metastases. Patients who had extracapsular spreading of the lymph node metastases or positive resection margins or who refused to undergo PORT were excluded. The prescribed dose of PORT was 60–66 Gy. Concurrent chemotherapy was optional. Patient characteristics, treatment parameters and clinical outcome were recorded. The primary end point was overall survival, and the secondary endpoint was disease status.ResultsThere were 138 eligible cases, and the median follow-up period was 35 months. The 3-year overall survival rate was 56%. Univariate analysis revealed that pathologic T4 status (pT4), bone marrow invasion, and lymphatic invasion were significantly correlated with poor outcome (p<0.05). Multivariate analysis showed that pT4, lymphatic invasion, and the no concurrent chemotherapy were independent poor prognostic factors (p<0.05). Fifty-four patients had tumor recurrence. The 3-year recurrence-free survival rate was 59%. Skin invasion, pT4, and bone marrow invasion were correlated with poor prognosis in the univariate analysis (p<0.05). Only pT4 (p<0.01) and no concurrent chemotherapy (p = 0.03) were independently correlated with poor recurrence-free survival.ConclusionFor OSCC patients with multiple-node metastases without extracapsular spreading or positive resection margins, PORT without concurrent chemotherapy correlated to inferior outcome. Multiple lymph node metastases might be considered an indication for concurrent chemotherapy.

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Cisplatin, tegafur, and leucovorin

Abstract: The preliminary results of this report were presented at

Cited by 59 publications

References 37 publications

Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan

Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan

Cystic nodal metastasis in patients with oropharyngeal squamous cell carcinoma receiving chemoradiotherapy: Relationship with human papillomavirus status and failure patterns

Postoperative Concomitant Chemoradiotherapy Improved Treatment Outcomes of Patients with Oral Cavity Cancer with Multiple-Node Metastases but No Other Major Risk Factors

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