Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects

Mendes, Johnatan Wellisson da Silva; Cunha, Walmir Emanuel Miranda; Rodrigues, Fábio Fernandes Galvão; Silveira, Edilberto R.; Lima, Roberta Dávila Pereira de; Costa, José Galberto Martins da

doi:10.1007/s11101-020-09695-4

Cited by 16 publications

(10 citation statements)

References 98 publications

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“…Ten skeletal types were identified in alkaloids of Cissampelos : benzylisoquinoline, BBI, aporphine, morphinandiene, tetrahydroprotoberberine, tropoloisoquinoline, azafluoranthene, pro-aporphine, stephaoxocan, and pyrrolic nucleus-derived alkaloid, etc. (48) The phylogenetically close Cissampelos and Cyclea share type Ⅴ, Ⅵ, Ⅷ, , , and BBIs (Appendix 4), and their BBI profi les are closer to Cocculus than to Menispermum, which is in accordance with their phylogenetic distance (Appendix 1). The composition of BBI may have chemotaxonomic significance.…”

Section: Chemical Composition Of Menispermaceaementioning

confidence: 64%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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Ranunculales is an order of angiosperms, containing 7 families, i.e., Ranunculaceae (at least 50 genera, >2,000 species), Berberidaceae (17 genera, 650 species), Menispermaceae (65 genera, >350 species), Lardizabalaceae (9 genera, 50 species), Circaeasteraceae (2 species), Papaveraceae (38 genera, >700 species), and Eupteleaceae (2 species, Appendix 1). Ranunculales belongs to the basal eudicots, in which it is the most basal clade; its widely known members include poppies, barberries, monseed, akebia and buttercupss. The chemodiversity of Ranunculaceae, the fl agship family of Ranunculales, and their correlation with the biodiversity and pharmacotherapy, have been systematically reviewed by us in the context of pharmacophylogeny. (1) In recent years, the research enthusiasm for the other 4 major Ranunculales families has been growing rapidly, as plants of these families also meet human needs for food, fl avours, fragrances, and not the least, medicines during long history. Ranunculales plants form the basis of sophisticated traditional medicine systems, e.g., Chinese medicine (CM) and Ayurveda medical system. (2) These systems of medicine give rise to some important Ranunculalesbased drugs still in use today. (3,4) According to incomplete statistics, 573 Ranunculaceae and 308 Berberidaceae species were in medicinally hot nodes; (4) the therapeutic efficacy of 2 families differed substantially. For instance, up to 361 Chinese Ranunculaceae species are used against musculoskeletal diseases, followed by 321 against hepatic diseases, 242 against circulatory diseases, and 210 against skin diseases, etc.; in contrast, as many as 251 Chinese Berberidaceae species are used against eyesight diseases, followed by 249 against hepatic diseases, 242 against digestive diseases and 90 against oral diseases, etc. Nevertheless, except Ranunculaceae, the

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Section: Chemical Composition Of Menispermaceaementioning

confidence: 64%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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“…This forms the basic definition for chemotaxonomy, which is the “closely related plants contain the same or similar chemical profiles” ( Hao and Xiao, 2020 ). As an example, in a review article published by da Silva Mendes et al. (2020) , many aspects of the Cissampelos genus were investigated, including the ethnobotanical aspects, isolated phytochemicals, and biological activity of the different species.…”

Section: Potential Leads From Southern African Plantsmentioning

confidence: 99%

“…The review, furthermore, describes the presence of similar compounds within different Cissampelos species. Many biological activities are attributed to warifteine, including results from clinical studies, and this compound was isolated from both Cissampelos ovalifolia and Cissampelos sympodialis ( da Silva Mendes et al., 2020 ). Another example is the Southern African species, Ziziphus mucronata , which has not been investigated for its antiviral activity; however, cyclopeptide alkaloids isolated from Z. jujuba showed inhibition of a porcine-related coronavirus (porcine epidemic diarrhea virus (PEDV)), with SI values ranging from 7.98 to 47.11 on Vero cells ( Kang et al., 2015 ).…”

Section: Potential Leads From Southern African Plantsmentioning

confidence: 99%

Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)

et al. 2020

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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the disease COVID-19, was declared a pandemic in early 2020. The objective of this review was to collate information regarding the potential of plants and natural products to inhibit coronavirus and targets associated with infection in humans and to highlight known drugs, which may have potential activity against SARS-CoV-2. Due to the similarity in the RNA genome, main proteases, and primary host receptor between SARS-CoV and SARS-CoV-2, a review was conducted on plants and secondary metabolites, which have shown activity against SARS-CoV. Numerous scientific reports on the potential of plants and secondary metabolites against SARS-CoV infection were found, providing important information on their possible activity against SARS-CoV-2. Based on current literature, 83 compounds have been identified with the potential to inhibit COVID-19. The most prominent selectivity was found for the alkaloid, lycorine, the lignan, savinin, and the abietane terpenoid, 8-beta-hydroxyabieta-9(11),13-dien-12-one with selectivity index values greater than 945, 667, and 510, respectively. Plants and their secondary metabolites, with activity against targets associated with the SARS-CoV infection, could provide valuable leads for the development into drugs for the novel SARS-CoV-2. The prospects of using computational methods to screen secondary metabolites against SARS-CoV targets are briefly discussed, and the drawbacks have been highlighted. Finally, we discuss plants traditionally used in Southern Africa for symptoms associated with respiratory viral infections and influenza, such as coughs, fever, and colds. However, only a few of these plants have been screened against SARS-CoV. Natural products hold a prominent role in discovering novel therapeutics to mitigate the current COVID-19 pandemic; however, further investigations regarding in vitro, in vivo, pre-clinical, and clinical phases are still required.

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“…In South America, it is used by natives for treating menstrual cramps, preventing miscarriage, easing childbirth, ceasing uterine hemorrhages after childbirth attributed to its property for relaxing smooth muscle. Leaves of C.pareira are traditionally used in the treatment of ulcers, urinary tract infections [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, leaves are rich in Laudanosine, dicentrine, magnoflorine, nuciferine; roots are rich in insularine, cycleanine, cissampareine, (-) -curine, hayatinine, isochondodendrine, pelosine, (+)berberine, diajisong, (+)-corytuberine, dihydrodicentrine, steponine, (-)-cissamine, (-)βcyclanoline, isoimerubrine, pareirubrine A & B, grandirubrine, pareitropone, norimeluteine, norruffscine, sepeerine, (-)-oblongine, (+)obaberine, (+)-obamegine, (+)-homoaromoline, (-)-nor-N'-chondrocurine, (+)-tetrandrine, berberine, phanostenine; stems contain cissampareine, magnoflorine, nuciferine. The leaves are also rich in flavonoids viz quercetin 3-O-sophoroside, naringenin 7-OD-glucoside, eriodictyl-7-O-beta-D-glucoside, galangin-7glucoside and baicalein-7-O-glucoside; roots have been reported to have quercetin and its aerial part is known to contain cissampeloflavoid [6,7].…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

Asif¹,

Gilani

Taleuzzaman³

et al. 2021

APRJ

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Aim: The present work deals with the GC-MS-analysis of chemical constituents of hydroalcoholic extract of Cissampelos pareira leaves and thier anti-diabetic activity. Methods: GC-MS analysis of extract was performed using Shimadzu QP-2010 plus with thermal desorption system 20. Acute oral toxicity of extract was done using the Organization of Economic Co-operation and Development (OECD) guideline 423. Diabetes was induced by single dose of streptozotocin 65 mg/kg, i.p. to all the rats except in rats of control group. Following which oral glucose tolerance test was performed and the rats were divided into various experimental groups. Various treatments continued for 21 days. Parameters such as blood glucose level, body weight, liver enzymes, lipid profiles and oxidative markers were checked. Results: GC-MS analysis of the extract identified 25 compounds present in it. Based on acute oral toxicity study three doses of hydroalcoholic extract of Cissampelos pareira leaves viz 100, 200 and 400 mg/kg were selected for evaluation of anti-diabetic activity. The extracts at doses 200 and 400 mg/kg BW were able to reduce blood sugar level, liver enzymes, total cholesterol, total triglyceride, low density lipoprotein and Malondialdehyde; and enhance body weight, high density lipoprotein and Glutathione significantly when compared to rats of negative control group. The effect of extract at dose 400 mg/kg was comparable to standard Glibenclamide. Conclusion: Results conclude that the chemical constituents present in the hydroalcoholic extract of Cissampelos pareira contained some anti-diabetic compounds possessing strong anti-diabetic activity.

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Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects

Cited by 16 publications

References 98 publications

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)

GC-MS Analysis of Chemical Constituents of Hydroalcoholic Leaf Extract of Cissampelos Pareira and Their Anti-Diabetic Activity

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